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Prenatal Tarama Testleri ve Hücreden Bağımsız Fetal DNA

Yıl 2020, Cilt: 27 Sayı: 2, 254 - 260, 01.06.2020
https://doi.org/10.17343/sdutfd.605545

Öz

Prenatal tarama
testlerinin kullanım amacı gebeliğin erken haftalarında kromozomal anöplöidi
açısından yüksek risk taşıyan gebelerin tesbit edilmesi ve her gebenin mevcut
riskleri ve tercihleri göz önünde bulundurularak bilgilendirilmesidir. Son
yıllarda prenatal tarama testleri geleneksel prenatal tarama testleri ve
hücreden bağımsız fetal DNA (cffDNA, fetal DNA, NIPT) olarak ikiye
ayrılmaktadır.
Maternal kandan biyobelirteçlerin ölçülüp
ultrasonografik bulgularla kombine edildiği geleneksel prenatal tarama testleri
halen birinci tercih olarak önerilmektedir. cffDNA ile gebeliğin 10.
haftasından itibaren maternal kanda yeni nesil sekanslama teknikleri
kullanılarak fetal DNA fragmanları analiz edilmektedir. Günümüzde hangi
popülasyona cffDNA testinin önerileceği, klinik kullanımda faydası, maliyeti,
limitasyonları ve avantajları  tartışmalı bir konudur.

Kaynakça

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Toplam 52 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Derlemeler
Yazarlar

Fevziye Burcu Şirin 0000-0001-5304-1007

Yayımlanma Tarihi 1 Haziran 2020
Gönderilme Tarihi 16 Ağustos 2019
Kabul Tarihi 25 Ekim 2019
Yayımlandığı Sayı Yıl 2020 Cilt: 27 Sayı: 2

Kaynak Göster

Vancouver Şirin FB. Prenatal Tarama Testleri ve Hücreden Bağımsız Fetal DNA. SDÜ Tıp Fak Derg. 2020;27(2):254-60.

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