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Outcomes and Complications of Parotidectomy in Benign and Malignant Salivary Gland Tumors: A Single-Center Retrospective Study

Year 2025, Volume: 32

Abstract

Objective: To retrospectively evaluate the demographic data, imaging, biopsy, and surgical outcomes of 98 patients who underwent parotidectomy.
Material and Method: Ninety-eight patients followed up and operated on for parotid masses between January 2020 and December 2023 in the ENT department of Antalya Training and Research Hospital were included in the study. The patient's gender, age, presenting complaints, comorbidities, fine-needle biopsy results, imaging results, surgical procedures performed, pathology results, and complications were evaluated.
Results: Among the patients who underwent surgery, 39 were female (39.8%) and 59 were male (60.2%). 96.8% of the patients reported experiencing swelling in front of the ear. Pathological results revealed that 81.7% of the patients were operated on for benign reasons, while 18.3% were operated on for malignant reasons. On average, after 2 years of follow-up, 97% of our patients continue their follow-ups in good health without disease.
Conclusion: Most salivary gland tumors are found in the parotid gland, with around 80% of these being benign. In this study, consistent with the literature, 81.7% of the operated cases were benign pathologies.

Ethical Statement

This study was conducted in accordance with the decision No. 3/12 dated March 21.2024, by the Clinical Research Ethics Committee of Antalya Training and Research Hospital. The study was conducted in line with the principles of the Helsinki Declaration. In this study, we undertake that all the rules that must be followed within the scope of the "Higher Education Institutions Scientific Research and Publication Ethics Directive" have been complied with, and that none of the actions specified under the heading of "Actions contrary to scientific research & publication ethics" of the mentioned directive have been carried out.

Project Number

3/12

References

  • 1. Gooden E, Witterick IJ, Hacker D, Rosen IB, Freeman JL. Parotid gland tumors in 255 consecutive patients: Mount Sinai Hospital’s Quality Assurance Review. J Otolarygol 2002;31:351–4.
  • 2. Dostalova L, Kalfert D, Jechova A, et al. The role of fine-needle aspiration biopsy (FNAB) in the diagnostic management of parotid gland masses with emphasis on potential pitfalls. Eur Arch Otorhinolaryngol 2020;277:1763–1769 https://doi.org/10.1007/s00405-020-05868-1.
  • 3. Sowa P, Goroszkiewicz K, Szydelko J, et al. A review of selected factors of salivary gland tumors formation and malignant transformation. BioMed Res Int 2018;2897827 doi:10.1155/2018/2897827.
  • 4. Guintinas-Lichius O, Klussmann JP, Wittekindt C, Stennert E. Parotidectomy for benign parotid disease at a university teaching hospital: Outcome of 963 operations. Laryngoscope 2006;116:534-40.
  • 5. Rehani AR, Bishen KA, Sagari S. Warthin's Tumour: A case report and review on pathogenesis and its histological subtypes. J Clin Diagn Res 2014;8(9). doi: 10.7860/JCDR/2014/8503.4908.
  • 6. World Health Organization. WHO global report on trends in prevalence of tobacco use 2000–2025. 4th ed. Geneva: WHO; 2021.
  • 7. Atalay B, Bora F, Ceylan S, et al. Tükürük bezi kitlelerinde histopatolojik çeşitlilik: 158 olgunun analizi. SDÜ Tıp Fak Derg 2011;18(3):82-5.
  • 8. Brodetskyi IS, Dyadyk OO, Myroshnychenko MS, Zaritska VI. Morphological characteristics of pleomorphic adenomas of salivary glands (analysis of the surgical material). Wiad Lek 2020;73(11):2339-44.
  • 9. McLean-Holden AC, Bishop JA. Low molecular weight cytokeratin immunohistochemistry reveals that most salivary gland Warthin tumors and lymphadenomas arise in intraparotid lymph nodes. Head Neck Pathol 2021;15(2):438-42. doi: 10.1007/s12105-020-01215-2.
  • 10. Klussmann JP, Wittekindt C, Preuss SF, Al Attab A, Schroeder U, Guntinas-Lichius O. High risk for bilateral Warthin tumor in heavy smokers: review of 185 cases. Acta Otolaryngol 2006;126(11):1213-7. doi: 10.1080/00016480600740605.
  • 11. İnan HM, Kıran MM, Kutluhan A, Şerifler S. Tükürük bezi neoplazilerinde klinik tecrübemiz; 222 olgunun analizi. JAMER 2019;4(2):57-63.
  • 12. Warthin, A.S. Papillary cystadenoma lymphomatosum. A rare teratoid of the parotid region. J. Cancer Res 1929;13:116–125.
  • 13. Quer M, Hernandez-Prera JC, Silver CE, et al. Current trends and controversies in the management of warthin tumor of the parotid gland. Diagnostics 2021;11:1467. https://doi.org/10.3390/ diagnostics11081467.
  • 14. Kadletz L, Grasl S, Perisanidis C, et al. Rising incidences of Warthin’s tumors may be linked to obesity: A single-institutional experience. Eur. Arch. Oto-Rhino-Laryngol 2019;276:1191–1196.
  • 15. González-García R, Nam-Cha SH, Muñoz-Guerra MF, Gamallo-Amat C. Basal cell adenoma of the parotid gland: Case report and review of the literature. Med Oral Patol Oral Cir Bucal 2006;11(2).
  • 16. Yu GY, Ubmüller J, Donath K. Membranous basal cell adenoma of the salivary gland: a clinicopathologic study of 12 cases. Acta Otolaryngol 1998;118(4):588-93. doi: 10.1080/00016489850154775. PMID: 9726688.
  • 17. Ranguelov RD, Robinson RA. Pathologic quiz case: A 79-year-old woman with an asymptomatic oropharyngeal mass. Arch Pathol Lab Med 2003;127(1). doi: 10.5858/2003-127-e53-PQC7YO.
  • 18. Bradley PJ, McGurk M. Incidence of salivary gland neoplasms in a defined UK population. Br J Oral Maxillofac Surg 2013;51(5):399-403. doi:10.1016/j.bjoms.2012.10.002.
  • 19. Chen MM, Roman SA, Sosa JA, Judson BL. Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population-level analysis of 2400 patients. Head Neck 2014;36:158-63. doi: 10.1002/hed.23256.
  • 20. van Weert S, Reinhard R, Bloemena E, et al. Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck. Head Neck 2017;39(3):456-63. doi: 10.1002/hed.24613.
  • 21. Neskey DM, Klein JD, Hicks S, et al. Prognostic factors associated with decreased survival in patients with acinic cell carcinoma. JAMA Otolaryngol Head Neck Surg 2013;139(11):1195-202. doi: 10.1001/jamaoto.2013.4728.
  • 22. Taxy JB. Squamous carcinoma in a major salivary gland: A review of the diagnostic considerations. Arch Pathol Lab Med 2001;125(6):740-5. doi: 10.5858/2001-125-0740-SCIAMS.
Year 2025, Volume: 32

Abstract

Project Number

3/12

References

  • 1. Gooden E, Witterick IJ, Hacker D, Rosen IB, Freeman JL. Parotid gland tumors in 255 consecutive patients: Mount Sinai Hospital’s Quality Assurance Review. J Otolarygol 2002;31:351–4.
  • 2. Dostalova L, Kalfert D, Jechova A, et al. The role of fine-needle aspiration biopsy (FNAB) in the diagnostic management of parotid gland masses with emphasis on potential pitfalls. Eur Arch Otorhinolaryngol 2020;277:1763–1769 https://doi.org/10.1007/s00405-020-05868-1.
  • 3. Sowa P, Goroszkiewicz K, Szydelko J, et al. A review of selected factors of salivary gland tumors formation and malignant transformation. BioMed Res Int 2018;2897827 doi:10.1155/2018/2897827.
  • 4. Guintinas-Lichius O, Klussmann JP, Wittekindt C, Stennert E. Parotidectomy for benign parotid disease at a university teaching hospital: Outcome of 963 operations. Laryngoscope 2006;116:534-40.
  • 5. Rehani AR, Bishen KA, Sagari S. Warthin's Tumour: A case report and review on pathogenesis and its histological subtypes. J Clin Diagn Res 2014;8(9). doi: 10.7860/JCDR/2014/8503.4908.
  • 6. World Health Organization. WHO global report on trends in prevalence of tobacco use 2000–2025. 4th ed. Geneva: WHO; 2021.
  • 7. Atalay B, Bora F, Ceylan S, et al. Tükürük bezi kitlelerinde histopatolojik çeşitlilik: 158 olgunun analizi. SDÜ Tıp Fak Derg 2011;18(3):82-5.
  • 8. Brodetskyi IS, Dyadyk OO, Myroshnychenko MS, Zaritska VI. Morphological characteristics of pleomorphic adenomas of salivary glands (analysis of the surgical material). Wiad Lek 2020;73(11):2339-44.
  • 9. McLean-Holden AC, Bishop JA. Low molecular weight cytokeratin immunohistochemistry reveals that most salivary gland Warthin tumors and lymphadenomas arise in intraparotid lymph nodes. Head Neck Pathol 2021;15(2):438-42. doi: 10.1007/s12105-020-01215-2.
  • 10. Klussmann JP, Wittekindt C, Preuss SF, Al Attab A, Schroeder U, Guntinas-Lichius O. High risk for bilateral Warthin tumor in heavy smokers: review of 185 cases. Acta Otolaryngol 2006;126(11):1213-7. doi: 10.1080/00016480600740605.
  • 11. İnan HM, Kıran MM, Kutluhan A, Şerifler S. Tükürük bezi neoplazilerinde klinik tecrübemiz; 222 olgunun analizi. JAMER 2019;4(2):57-63.
  • 12. Warthin, A.S. Papillary cystadenoma lymphomatosum. A rare teratoid of the parotid region. J. Cancer Res 1929;13:116–125.
  • 13. Quer M, Hernandez-Prera JC, Silver CE, et al. Current trends and controversies in the management of warthin tumor of the parotid gland. Diagnostics 2021;11:1467. https://doi.org/10.3390/ diagnostics11081467.
  • 14. Kadletz L, Grasl S, Perisanidis C, et al. Rising incidences of Warthin’s tumors may be linked to obesity: A single-institutional experience. Eur. Arch. Oto-Rhino-Laryngol 2019;276:1191–1196.
  • 15. González-García R, Nam-Cha SH, Muñoz-Guerra MF, Gamallo-Amat C. Basal cell adenoma of the parotid gland: Case report and review of the literature. Med Oral Patol Oral Cir Bucal 2006;11(2).
  • 16. Yu GY, Ubmüller J, Donath K. Membranous basal cell adenoma of the salivary gland: a clinicopathologic study of 12 cases. Acta Otolaryngol 1998;118(4):588-93. doi: 10.1080/00016489850154775. PMID: 9726688.
  • 17. Ranguelov RD, Robinson RA. Pathologic quiz case: A 79-year-old woman with an asymptomatic oropharyngeal mass. Arch Pathol Lab Med 2003;127(1). doi: 10.5858/2003-127-e53-PQC7YO.
  • 18. Bradley PJ, McGurk M. Incidence of salivary gland neoplasms in a defined UK population. Br J Oral Maxillofac Surg 2013;51(5):399-403. doi:10.1016/j.bjoms.2012.10.002.
  • 19. Chen MM, Roman SA, Sosa JA, Judson BL. Histologic grade as prognostic indicator for mucoepidermoid carcinoma: A population-level analysis of 2400 patients. Head Neck 2014;36:158-63. doi: 10.1002/hed.23256.
  • 20. van Weert S, Reinhard R, Bloemena E, et al. Differences in patterns of survival in metastatic adenoid cystic carcinoma of the head and neck. Head Neck 2017;39(3):456-63. doi: 10.1002/hed.24613.
  • 21. Neskey DM, Klein JD, Hicks S, et al. Prognostic factors associated with decreased survival in patients with acinic cell carcinoma. JAMA Otolaryngol Head Neck Surg 2013;139(11):1195-202. doi: 10.1001/jamaoto.2013.4728.
  • 22. Taxy JB. Squamous carcinoma in a major salivary gland: A review of the diagnostic considerations. Arch Pathol Lab Med 2001;125(6):740-5. doi: 10.5858/2001-125-0740-SCIAMS.
There are 22 citations in total.

Details

Primary Language English
Subjects Surgery (Other)
Journal Section Research Articles
Authors

Rezarta Taga Senirli 0000-0002-3866-2152

Yeşim Yüksel 0000-0003-2280-3843

Muhammet Yıldız 0000-0002-1771-7345

Nuray Ensari 0000-0002-3373-9173

Özer Gür 0000-0002-2846-4136

Project Number 3/12
Early Pub Date February 18, 2025
Publication Date
Submission Date July 27, 2024
Acceptance Date December 24, 2024
Published in Issue Year 2025 Volume: 32

Cite

Vancouver Taga Senirli R, Yüksel Y, Yıldız M, Ensari N, Gür Ö. Outcomes and Complications of Parotidectomy in Benign and Malignant Salivary Gland Tumors: A Single-Center Retrospective Study. Med J SDU. 2025;32.

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