Sülfanilamit İçeren Maleik Asit ile Aminopiridin Türevlerinin Proton Tuzlarının Sentezi ve Karakterizasyonu

Yıl 2022, , 57 - 70, 29.06.2022

Halil İlkimen , Cengiz Yenikaya

https://doi.org/10.33484/sinopfbd.1069649

Cited By: 1

Öz

Bu çalışmada önce literatürde bulunan yöntemle maleik anhidrit (mal) ile sülfanilamitin (sa) tepkimesinden sülfanilamit içeren maleik asit olan (E)-3-(4-sülfamoilfenilkarbamoil) akrilik asit (1) sentezlenmiştir. Daha sonra 1 ile 2-amino-6-metilpiridin (2), 2-amino-5-metilpiridin (3), 2-amino-4-metilpiridin (4) ve 3-aminopiridin (5) tepkimesinden proton transfer tuzları (6-9) elde edilmiştir. Elde edilen tuzların yapıları, elementel analiz, 1H ve 13C Nükleer Manyetik Rezonans Spektroskopisi (NMR), Fourier Dönüşümlü Kızılötesi Spektroskopisi (FT-IR) ve yük denkliği ile önerilmiştir. Bu analiz sonuçlarına göre tuzlarda asit:baz oranı 1:1 olarak bulunmuştur. Bu çalışmada, suda çözülebilen ve farklı aktivite özellikleri gösterebilecek kimyasal madde sentezi hedeflenmiştir.

Anahtar Kelimeler

(E)-3-(4-sülfamoyilfenilkarbamoil)akrilik asit, Aminopiridinler, Proton Transfer Tuzu

Destekleyen Kurum

Kütahya Dumlupınar Üniversitesi

Proje Numarası

2013/36

Teşekkür

Bu çalışma, Kütahya Dumlupınar Üniversitesi Bilimsel Araştırma Projeleri Komisyon’unca, 2013/36 numaralı proje olarak desteklenmiştir. Bu katkılarından dolayı Kütahya Dumlupınar Üniversitesi Bilimsel Araştırma Projeleri Komisyonu’na teşekkür ederiz.

Synthesis and Characterization of Proton Salts of Sulfanilamide Containing Maleic Acid and Aminopyridine Derivatives

Öz

In this study, maleic acid containing sulfanilamide (E)-3-(4-sulfamoylphenylcarbamoyl) acrylic acid (1) was synthesized from the reaction of maleic anhydride (mal) and sulfanilamide (sa) with the method found in the literature. Then, proton transfer salts (6-9) were obtained. The structures of the obtained salts were suggested by elemental analysis, 1H and 13C Nuclear Magnetic Resonance Spectroscopy (NMR), Fourier Transform Infrared Spectroscopy (FT- IR) and charge balance. According to the results of this analysis, the acid:base ratio of salts was found to be 1:1. In this study, it was aimed to synthesize chemical substances that can be dissolved in water and have different activity properties.

Anahtar Kelimeler

(E)-3-(4-sulfamoylphenylcarbamoyl)acrylic acid, Aminopyridines, Proton Transfer Salt

Proje Numarası

2013/36

Kaynakça

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