İdealize Edilmiş Bir Aort Anevrizması Geometrisinde Quemada Viskozite Formülasyonuna Dayalı Yeni Bir Anevrizma-Duyarlı Non-Newtonian Kan Akış Modelinin Karşılaştırmalı Hemodinamik Analizi

Öz

Bu çalışma, idealize edilmiş bir aort anevrizması geometrisinde Newtonyen model ile Quemada tabanlı, uyarlanmış Anevrizma-Duyarlı Newtonyen olmayan kan akışı modelinin karşılaştırmalı hesaplamalı akışkanlar dinamiği (CFD) analizini sunmaktadır. Önerilen model, yerel kesme hızı ve damar morfolojisine bağlı olarak kan viskozitesini dinamik biçimde güncelleyen hematolojik ve hemodinamik düzeltme çarpanlarını Quemada viskozite formülasyonuna entegre eder. Bu uyarlama, anevrizma kesesi içinde birlikte görülen kesme incelmesi ve eritrosit agregasyonu kaynaklı reolojik karmaşıklığı daha gerçekçi temsil etmeyi sağlamaktadır. Fizyolojik nabızlı akış koşulları altında, model duvar kayma gerilmesi (WSS) dağılımlarında daha yüksek doğruluk, osilatuar kayma indeksi (OSI) alanlarında daha düzgün bir yayılım ve bağıl kalma süresi (RRT) bölgelerinde belirgin bir azalma üretmiştir. Klasik Newtonyen varsayımla karşılaştırıldığında, yeni formülasyon gerçekçi olmayan yeniden dolaşımı bastırmış ve viskozitenin kalp çevrimi boyunca zamansal değişimini yakalamıştır. Bulgular, Newtonyen modelin küresel akış eğilimlerini nitel olarak yakalamasına karşın, önerilen Anevrizma-Duyarlı Newtonyen olmayan modelin anevrizmatik bölgelerde fizyolojik olarak tutarlı hemodinamiği nicel olarak yeniden ürettiğini göstermektedir. Sonuç olarak, model, hasta spesifik anevrizma hemodinamiğinin incelenmesi ve biyomekanik risk değerlendirmelerinin iyileştirilmesi için güvenilir ve yenilikçi bir çerçeve sunmaktadır.

Anahtar Kelimeler

• Aort anevrizması
• Newtonyen olmayan kan akışı
• Hesaplamalı Akışkanlar Dinamiği (HAD)
• Duvar kayma gerilmesi
• Hemodinamik analiz

Destekleyen Kurum

Çalışma kapsamında herhangi bir destek alınmamıştır.

Etik Beyan

Çalışma, etik kurul izni veya herhangi bir özel izin gerektirmemektedir.

Comparative Hemodynamic Analysis of a Newly Developed Aneurysm-Aware Non-Newtonian Blood Flow Model Based on the Quemada Viscosity Formulation in an Idealized Aortic Aneurysm Geometry

Öz

This study presents a comparative computational fluid dynamics (CFD) analysis of a Newtonian model and a modified Quemada-based aneurysm-sensitive non-Newtonian blood flow model in an idealized aortic aneurysm geometry. The proposed model dynamically updates blood viscosity as a function of local shear rate and vascular morphology, enabling a more realistic representation of the rheological complexity arising from shear-thinning behavior and erythrocyte aggregation within the aneurysm sac. Under physiological pulsatile flow conditions, the model yielded more consistent wall shear stress (WSS) distributions, a smoother spatial distribution of oscillatory shear index (OSI), and a marked reduction in regions of relative residence time (RRT). Compared with the classical Newtonian assumption, the new formulation suppressed non-physical recirculation and successfully captured the time-dependent behavior of viscosity throughout the cardiac cycle. Overall, while the Newtonian model qualitatively reproduced global flow trends, the aneurysm-sensitive non-Newtonian model more accurately quantified physiologically consistent hemodynamics within aneurysmal regions.

Anahtar Kelimeler

• Aortic aneurysm
• non-Newtonian blood flow
• Computational Fluid Dynamics (CFD)
• Wall shear stress
• Hemodynamic analysis

Destekleyen Kurum

No funding was received for this study.

Etik Beyan

The study does not require ethics committee approval or any special permission.

Kaynakça

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