Xanthelasma Palpebrarum is Associated with Higher Levels of Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratio

Yıl 2018, , 63 - 69, 26.03.2018

Selim Kul , Ali Rıza Akyüz

https://doi.org/10.31832/smj.370441

Öz

Background:
According
to many epidemiologic studies, Xanthelasma Palpebrarum (XP) is thought to be a
determinant of an increased risk of atherosclerosis. Many studies have show
that inflammation plays an important role in the progress of atherosclerosis. Platelet
to lymphocyte ratio (PLR) and Neutrophil to lymphocyte ratio (NLR) is a marker
of systemic inflammation that correlates with mortality and cardiac events in
several cardiovascular diseases. We aimed to investigate the relationship
between PLR, NLR and XP in this study.

Methods: Sixty-six  subjects with XP and age and sex matched 66 control
subjects were enrolled in the present study. Patients with known atherosclerotic vascular diseases
were excluded. Baseline characteristics such as presence of hypertension,
diabetes mellitus, hyperlipidemia, cigarette smoking history, medications and
hematological parameters were compared between the two groups.

Results: Subjects
with XP had higher levels of total cholesterol (217±54 mg/dl vs. 197±41mg/dl, p=0.04), low density lipoprotein cholesterol  (143±45 mg/dl vs. 120±33 mg/dl, p=0.002), triglyceride levels (174±91 vs. 149±95, p=0.02), NLR (1.8±0.8 vs. 1.5±0.5,
p=0.004) and PLR (117±35 vs. 100±29,
p=0.004)  than those in control subjects.

Conclusion: In the present study we
found that NLR and PLR levels, which are indicative of systemic inflammation
and multiple adverse cardiovascular outcomes, were higher in the XP patients.
This suggests that XP patients may need a close follow-up for cardiac risk
factors. 

Anahtar Kelimeler

Xanthelasma, inflammation

Xanthelasma Palpebrarum Artmış Nötrofil/Lenfosit ve Platelet/Lenfosit Oranı ile İlişkilidir

Öz

Giriş: Epidemiyolojik
çalışmalarda, Xanthelasma Palpebrarum (XP) artmış ateroskleroz riskinin
belirleyicisi olduğu görülmüştür. Birçok çalışma, inflamasyonun ateroskleroz
gelişiminde önemli bir rol oynadığını göstermektedir. Trombosit / lenfosit
oranı ve nötrofil / lenfosit oranı , çeşitli kardiyovasküler hastalıklarda
mortalite ve kardiyak olaylarla ilişkili olan sistemik inflamasyonun bir
işaretidir. Bu çalışmada, trombosit / lenfosit oranı ve nötrofil / lenfosit
oranı ile XP arasındaki ilişkiyi araştırmayı amaçladık.

Metod: Çalışmaya
66 XP olan ve yaş, cinsiyet eşleştirilmiş 66 kontrol hasta alındı. Bilinen
aterosklerotik vasküler hastalığı olanlar çalışma dışı bırakıldı. Her iki
grupta hipertansiyon, diabetes mellitus, hiperlipidemi, sigara kullanımı
öyküsü, medikal tedavi öyküsü ve hematolojik parametreler gibi temel özellikler
karşılaştırıldı.

Sonuç: XP
olan olguların total kolestrol seviyeleri (217 ± 54 mg / dl'a karşılık 197 ± 41
mg / dl, p = 0.04), düşük yoğunluklu lipoprotein kolesterol düzeyleri (143 ± 45
mg / dl'ye karşı 120 ± 33 mg / dl, p = 0.002), trigliserit düzeyleri (174 ± 91
karşı 149 ± 95, p = 0.02), nötrofil/lenfosit 
(1.8 ± 0.8'e karşı 1.5 ± 0.5, p = 0.004) ve platelet/lenfosit (117 ±
35'e karşı 100 ± 29, p = 0.004) kontrol gruptan daha yüksekti.

Tartışma: Bu
çalışmada, XP hastalarında sistemik inflamasyon ve istenmeyen kardiyovasküler
sonuçların göstergesi olan nötrofil/lenfosit oranı ve platelet/lenfosit oranı
düzeylerinin daha yüksek olduğunu bulduk. Bu, XP hastalarının kardiyak risk
faktörleri için yakın izlem gerektirebileceğini göstermektedir.

 

Anahtar Kelimeler

Ksantelezma, inflamasyon

Kaynakça

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