Investigation of the Levels of Copper, Iron, Zinc, Selenium and Ratios of Cu/Se, Cu/Zn, Fe/Se, Fe/Zn in Patients with Hashimoto Thyroiditis

Yıl 2018, , 285 - 291, 29.06.2018

Fatma Behice Serinkan Cinemre , Nurten Bahtiyar Bahtiyar , Esra Ertan Sevgin Değirmencioğlu Nilgun Dilaveroğlu Ayse Erdogan Çakar , Hakan Cinemre , Birsen Aydemir

https://doi.org/10.31832/smj.424877

Cited By: 1

Öz

Objective Our aim was to investigate relationship of serum selenium(Se), zinc(Zn), copper(Cu) and iron(Fe) levels and ratios of Cu/Se, Cu/Zn, Fe/Se
and Fe/Zn with etiopathogenesis of Hashimoto Thyroiditis (HT). ( Sakarya Med J, 2018, 8(2):285-291 ).
Materials and
Methods
Thirty-fi ve patients with HT and 28 healthy controls were included. Serum Se, Fe, Cu and Zn were measured by inductively coupled plasma
optical emission spectrometry (ICP-OES) and Cu/Se, Cu/Zn, Fe/Se and Fe/Zn ratios were calculated.
Results Serum selenium, iron, copper and zinc levels were signifi cantly decreased in HT patients group (p<0,001, p<0,001, p<0,05 and p<0,001,
respectively). However, Cu/Zn and Cu/Se ratios were signifi cantly increased in HT patients (p<0,05). In HT patients, there were positive
correlations between Cu and Cu/Zn; between Fe/Se and Cu/Se ratios; between Fe/Zn and Fe/Se ratios (p<0,01). In the same group, Fe
levels were also positively correlated with Fe/Se and Fe/Zn ratios (p<0,01). However, Se level was negatively correlated with Cu/Se and Fe/
Se ratios (p<0,01). Additionally, Zn was negatively correlated with Cu/Zn ratio (p<0,01).
Conclusion Our results showed that together with trace element levels and ratios were involved in HT etiopathogenesis. Details of mechanisms underlying the disease should be clarifi ed with further studies.

Anahtar Kelimeler

Hashimoto Thyroiditis, Se, Zn, Cu, Fe, Cu/Se, Cu/Zn, Fe/Se, Fe/Zn

Hashimoto Tiroiditli Hastalarda Bakır, Demir, Çinko, Selenyum Düzeyleri ve Cu/Se, Cu/Zn, Fe/Se, Fe/Zn Oranlarının Araştırılması

Öz

Amaç: Bu çalışmanın
amacı, Hashimoto tiroiditi (HT)
etiyopatogenezinde selenyum (Se) demir (Fe), çinko
(Zn) ve bakır (Cu) eser elementlerinin serum düzeylerindeki ve
oranlarındaki değişimlerinin belirlenmesi ve bu parametreler arasındaki olası ilişkinin
değerlendirilmesidir.

Gereç ve Yöntem: Çalışma
35 HT ve 28 sağlıklı birey ile gerçekleştirildi. Çalışmaya dahil edilen tüm
bireylere ait serum Se, Zn, Cu ve Fe düzeyleri indüktif
eşleşmiş plazma optik emisyon spektrofotometresi (ICP-OES, Thermo iCAP 6000) ile
ölçüldü.

Bulgular: Serum
Se, Fe, Cu ve Zn düzeylerinin HT grubunda kontrol grubuna göre anlamlı derecede
azaldığı saptandı (sırasıyla p<0,001,
p<0,001, p<0,05 ve p<0,001). Cu/Zn ve Cu/Se oranlarının HT grubunda arttığı görüldü.  Ayrıca, HT grubunda Cu düzeyleri ile Cu/Zn
oranı; Fe/Se ile Cu/Se oranları; Fe/Zn ile Fe/Se oranları; Fe düzeyleri ile
Fe/Se ve Fe/Zn oranları arasında pozitif
korelasyon olduğu belirlendi.  Se
düzeylerinin Cu/Se ve Fe/Se oranları ile negatif korelasyon gösterdi.  Zn düzeyleri de Cu/Zn oranı ile negatif
korelasyon göstermiştir.

Sonuç: Çalışmamızın sonuçları, eser element
düzeyleri ve oranlarının HT etiyopatogenezinde yer aldığını göstermektedir. Hastalığın altta yatan
mekanizmaları ile eser element ve oranlarının etkileşiminin aydınlatılması için
daha ileri çalışmalara ihtiyaç duyulmaktadır. 

Anahtar Kelimeler

Hashimoto tiroiditi, Se, Zn, Cu, Fe, Cu/Se, Cu/Zn, Fe/Se

Kaynakça

• Referans 1. Rostami, R, Aghasi M, Mohammadi A, Nourooz-Zadeh J. Enhanced oxidative stress in Hashimoto's thyroiditis: inter-relationships to biomarkers of thyroid function. Clin Biochem 2013; 46: 308-12.
• Referans 2. van Zuuren EJ, Albusta AY, Fedorowicz Z, Carter B, Pijl H. Selenium supplementation for Hashimoto's thyroiditis: summary of a Cochrane Systematic Review. Eur Thyroid J 2014; 3: 25-31.
• Referans 3. Dellal FD, Niyazoglu M, Ademoglu E, Gorar S, Candan Z, Bekdemir H, Uc Z A. Senes, M.; Ozderya, A.; Aral, Y. Evaluation of serum trace elements and vitamin levels in Hashimoto’s Thyroiditis: Single centre Experience from Turkey. Open J Endocrin Metabc Dis 2013; 3: 236.
• Referans 4. Stehle P, Stoffel-Wagner B, Kuhn K. Parenteral trace element provision: recent clinical research and practical conclusions. Eur J Clin Nutr 2016; 70: 886.
• Referans 5. Erdal M, Sahin M, Hasimi A, Uckaya G, Kutlu M, Saglam K. Trace element levels in hashimoto thyroiditis patients with subclinical hypothyroidism. Biol Trace Elem Res 2008; 123: 1.
• Referans 6. Arthur JR, Beckett G J. Thyroid function. Brit Med Bull 1999; 55: 658-68.
• Referans 7. Nazifi S, Saeb M, Abangah E, Karimi T. Studies on the relationship between thyroid hormones and some trace elements in the blood serum of Iranian fat-tailed sheep. Vet Arh 2008; 78: 159.
• Referans 8. Mahmoodianfard S, Vafa M, Golgiri F, Khoshniat M, Gohari M, Solati Z, Djalali M. Effects of zinc and selenium supplementation on thyroid function in overweight and obese hypothyroid female patients: a randomized double-blind controlled trial. J Am Coll Nutr 2015; 34: 391-99.
• Referans 9. Arthur JR, Nicol F, Beckett GJ. The role of selenium in thyroid hormone metabolism and effects of selenium deficiency on thyroid hormone and iodine metabolism. Biol Trace Elem Res 1992; 33: 37-42.
• Referans 10. Mc Gregor B. Extra-Thyroidal factors impacting thyroid hormone homeostasis: a review. J Rest Med 2015; 4; 40-9. Referans 11. Przybylik-Mazurek E, Zagrodzki P, Kuźniarz-Rymarz S, Hubalewska-Dydejczyk A. Thyroid disorders—assessments of trace elements, clinical, and laboratory parameters. Biol Trace Elem Res 2011; 141: 65-75.
• Referans 12. Adedapo KS, Sonuga AA, Afolabi AO, Amosu A. Interaction of Some Selected Trace Elements with Thyroid Hormones in Patients with Goiter in Ibadan, Nigeria. J Scient Res Rep 2014;3( 22): 2875-2883.
• Referans 13. Duntas LH. The Role of Iodine and Selenium in Autoimmune Thyroiditis. Horm Metab Res 2015; 47(10): 721-6.
• Referans 14. Rasic-Milutinovic Z, Jovanovic D, Bogdanovic G, Trifunovic J, Mutic J.; Potential Influence of Selenium, Copper, Zinc and Cadmium on L-Thyroxine Substitution in Patients with Hashimoto Thyroiditis and Hypothyroidism. Exp Clin Endocrinol Diabetes 2017; 125(2): 79-85.