Epileptik Nöbet ve Saldırgan Davranış İle Başvuran Hastada İdiyopatik Hipoparatiroidi ve Bilateral Bazal Ganglion Kalsifikasyonu: Fahr Sendromu

Yıl 2020, , 505 - 508, 15.09.2020

Erkut Etçioğlu , İhsan Sarıkaya Abdülkadir Aydın , Abdulkadir Tunç , Ahmet Yıldırım

https://doi.org/10.31832/smj.693271

Öz

Fahr sendromu, simetrik ve bilateral intrakraniyal kalsifikasyon ile seyreden nadir bir hastalık tablosu olup psikiyatrik semptomlar, epileptik nöbetler, serebellar bulgular, ekstrapiramidal disfonksiyon ve demans gibi klinik belirtiler ile kendini gösterebilir. Hastalığın birçok farklı klinik tablosu olmasına rağmen etiyolojisi henüz net olarak bilinmemektedir. Bu yazıda epileptik nöbet ile başvuran ve psikiyatrik belirtileri olan Fahr sendromu olgusu sunmaktayız.

Fahr syndrome is a rare disease with symmetrical and bilateral intracranial calcium accumulation and may present with clinical symptoms such as psychiatric symptoms, epileptic seizures, cerebellar findings, extrapyramidal dysfunction and dementia. Although the disease has many different clinical manifestations, its etiology is not yet clear. In this article, we present a case of Fahr syndrome with psychiatric symptoms presenting with epileptic seizures.

Anahtar Kelimeler

Fahr Sendromu, İntrakraniyal kalsifikasyon, Epilepsi

Kaynakça

• 1. Manyam BV. What is and what is not ‘Fahr’s disease’. Parkinsonism Relat Disord. 2005; 11(2): 73-80. 2. Fahr T: Idiopathische verkalkung der hirngefässe. Zentrabl Allg Pathol, 1930; 50: 129–33. 3. Migliano MT, et al. Fahr’s disease and cerebrovascular disease: A case report and a literature review. Austin J Clin Neurol. 2018; 5(1): 1132. 4. Lazar M, Ion DA, Streinu-Cercel A, Badarau AI. Fahr’s syndrome: diagnosis issues in patients with unknown family history of disease. Rom J Morphol Embryo. 2009; 50(3): 425-8. 5. Lammie GA, Kelly PA, Baird JD, Smith W, Chatterjee S, Frier BM, et al. Basal ganglia calcification in BB/E rats with diabetes. J Clin Neurosci. 2005; 12: 49-53. 6. Avrahami E, Cohn DF, Feibel M, Tadmor R. MRI demonstration and CT correlation of the brain in patients with idiopathic intracerebral calcification. J Neurol. 1994; 241(6): 381-84. 7. Rossi M, Morena M, Zanardi M. Calcification of the basal ganglia and Fahr disease. Report of two clinical cases and review of the literature. Recenti Prog Med. 1993; 84(3): 192-8. 8. Hempel A, Henze M, Berghoff C et al: PET findings and neuropsychological deficits in a case of Fahr’s disease. Psychiatry Res, 2001; 108(2): 133–40. 9. López-Villegas D, Kulisevsky J, Deus J et al: Neuropsychological alterations in patients with computed tomography-detected basal ganglia calcification. Arch Neurol, 1996; 53(3): 251–56. 10. Shouyama M, Kitabata Y, Kaku T, Shinosaki K. Evaluation of regional cerebral blood flow in Fahr’s disease with schizophrenia-like psychosis: a case report. Am J Neuroradiol. 2005; 26: 2527-29. 11. Loeb JA, et al. Brain calcifications induce neurological dysfunction that can be reversed by a bone drug. J Neurol Sci. 2006; 243: 77-81. 12. Loeb JA. Functional improvement in a patient with cerebral calcinosis using a bisphosphonate. Mov Disord. 1998; 13(2): 345-9.