Erken Saç Beyazlaması Sağlıklı Genç ve Orta Yaşlı Erkekler için Hipertansiyonun Belirleyicisi midir?

Abstract

Amaç: Oksidatif stres, hipertansiyon (HT) gelişiminde temel faktörlerden biridir. Saç beyazlaması oksidatif stresin görsel bir işaretidir. Erken saç beyazlaması yoğunluğunun HT gelişimini öngörebileceğini varsaydık ve bunu test etmeyi amaçladık.
Gereç ve Yöntemler: Saç beyazlığı farklı derecelerde 172 sağlıklı erkek çalışmaya dahil edildi ve ortalama 86 ay sonunda değerlendirildi. Takip süresi boyunca HT tanısı alan hastaların verilerini sağlıklı kalanlarla karşılaştırdık.
Bulgular: Takip süresince 172 hastanın 53'üne (% 32) HT tanısı konuldu. Demografik özellikler açısından yaş (41,48 ± 6,39 vs 44,36 ± 5,25 yıl; p=0,013), bel çevresi (97,52 ± 10,87 vs 104,80 ± 11,94 cm; p=0,004) ve vücut-kitle indeksi (27,61 ± 3,56 vs 30,20 ± 3,55 kg / m2; p<0,001) HT grubunda daha fazla iken, sigara içme öyküsü (p=0,211) gruplar arasında benzerdi. Tek değişkenli analiz sonucunda karotis intima-media kalınlığı (KIMK)(p=0,013), gama-glutamil transferaz (GGT)(p=0,021) ve ürik asit (p<0,001) seviyeleri HT grubunda daha yüksek; tahmini glomerüler filtrasyon hızı (tGFH)(p=0,039) ve yüksek dansiteli lipoprotein (YDL)(p=0,026) düzeyleri ise daha düşüktü. Saç beyazlığı derecesi ve yoğunluğu açısından gruplar arasında fark yoktu. Çoklu değişkenli analiz yapıldığında, yaş (OR=0,143, 95%CI (1,002-1,328), p=0,046), tGFH (OR=-0,058, 95%CI (0,895-0,995), p=0,032), ürik asit (OR=0,567, 95%CI (1,032-3,015), p=0,038), GGT (OR=0,030, 95%CI (1,001-1,060), p=0,041) ve YDL kolesterol (OR=-0,129, 95%CI (0,783- 0,986), p=0,028) de nova HT ile bağımsız ilişkiliydi. Vücut-kitle indeksi, KIMK ve lökosit miktarı iki grup için benzerdi.
Sonuç: Erken saç beyazlaması, genç ve orta yaşlı sağlıklı erkeklerde HT gelişimini belirlemede öngörücü değildir. 

Keywords

• Hipertansiyon,oksidatif stres,genç,orta yaş,erkek,saç

Is Premature Hair Whitening a Predictor of Hypertension for Healthy Young and Middle-Aged Men?

Abstract

Objective: Oxidative stress is one of the essential factors in the development of Hypertension (HT). Hair whitening is a visual sign of oxidative stress. We hypothesized that the intensity of premature hair whitening might predict HT development, and we aimed to test it.
Materials and Methods: A total of 172 healthy males with different stages of hair whitening were included in the study and evaluated after an average of 86 months. During the follow-up, we compared the data of patients diagnosed with HT to those who remained healthy.
Results: Fifty-five (32%) of 172 patients were diagnosed with HT during follow-up period. In terms of demographic characteristics, age (41.48 ± 6.39 vs 44.36 ± 5.25 years; p=0.013), waist circumference (97.52 ± 10.87 vs 104.80 ± 11.94 cm; p=0.004), and body-mass index (27.61 ± 3.56 vs 30.20 ± 3.55 kg/m2; p<0,001) were higher in the HT group, whereas smoking history (p=0.211) was similar between the groups. In univariate analysis carotid intima-media thickness (CIMT)(p=0.013), gamma-glutamyl transferase (GGT)(p=0.021), and uric acid (p<0.001) levels were higher in the HT group; on the contrary, estimated glomerular filtration rate (eGFR)(p=0.039) and high-density lipoprotein (HDL) levels (p=0.026) were lower in this group. There was no difference between groups in terms of hair whitening stage and intensity. In multivariate analysis age (OR=0.143, 95%CI (1.002-1.328), p=0.046), eGFR (OR= -0.058, 95%CI (0.895-0.995), p=0.032), uric acid (OR=0.567, 95%CI (1.032-3.015), p=0.038), GGT (OR=0.030, 95%CI (1.001-1.060), p=0.041), and HDL (OR=-0.129, 95%CI (0.783- 0.986), p=0.028) were independently associated with de nova HT. Body-mass index, CIMT, and the leukocyte count were similar between the groups.
Conclusion: Premature hair whitening is not predictive in determining the development of HT in young and middle-aged healthy men. 

Keywords

• Hypertension,young,middle-aged,male,hair,oxidative stress

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