The Relationship Between Drug Resistance And Ferroptosis in Breast Cancer Cells Ferroptotic Process in Breast Cancer

Öz

Because of their iron-dependent nature, cancer cells are more prone to ferroptosis, an iron-catalyzed necrosis. Accumulating evidence suggests that ferroptotic cell death leads to suppression of tumor growth. Targeting ferroptosis could be a promising anticancer strategy. Recent discoveries of ferroptosis-inducing agents and further identification of the regulatory mechanisms and genes involved in ferroptosis provide a basis for developing strategies to target ferroptosis in cancer therapy. Therefore, a better understanding of the processes that regulate ferroptosis sensitivity should ultimately aid the discovery of new therapeutic strategies to improve cancer therapy. In line with the studies, they found that triple-negative breast cancer is more sensitive to ferroptosis than ER-positive breast cancer. The most essential problem in breast cancer treatment is death due to metastasis and drug resistance. Doxorubicin (Dox) is one of the most commonly used chemotherapeutic agents in treatment, and a significant portion of patients die due to treatment-related resistance. Targeting agents that will trigger different types of cell death in overcoming Dox resistance is an important issue, and targeting cancer cells via the ferroptotic pathway has recently become the focus of attention. In conclusion, triggering the ferroptotic cell death mechanism is considered a promising new approach in overcoming resistance in terms of the potential to drive cancer cells to death in treatment-resistant cancers. In this review, possible molecular mechanisms of action in terms of ferrroptotic cell death and breast cancer treatment resistance and reviewed.

Anahtar Kelimeler

• Ferroptosis
• Breast cancer
• Drug resistance
• Cancer

Meme Kanser Hücrelerinde Kanser Kaynaklı İlaç Direnci Ve Bağışıklıktan Kaçınmanın Kavşağında Ferroptoz

Öz

Demire olan bağımlılıkları, kanser hücrelerini ferroptoz olarak bilinen demir katalizli nekroza daha duyarlı hale getirir. Günümüze kadar elde edilen veriler, ferroptotik hücre ölümünün tümör büyümesinin baskılanmasına yol açtığını göstermektedir. Ferroptozu hedeflemek umut verici bir antikanser stratejisi olabilir. Bu sebeple ferroptozu indükleyen ajanların keşfinin devamlılığı ve ferroptozda yer alan düzenleyici mekanizmaların ve ilgili genlerin daha fazla tanımlanması, kanser tedavisinde ferroptozu hedeflemek için stratejiler geliştirmeye bir temel oluşturabilir. Ferroptoz duyarlılığını düzenleyen bu süreçlerin daha iyi anlaşılması, nihayetinde kanser tedavisini geliştirmek için yeni terapötik stratejilerin keşfedilmesine yardımcı olmalıdır. Yapılan çalışmalar doğrultusunda üçlü negatif meme kanserinin ferroptoza karşı ER pozitif meme kanserinden daha duyarlı olduğu belirtilmiştir. Meme kanseri tedavisindeki en önemli sorun, metastaz ve ilaç direncine bağlı ortaya çıkan ölümdür. Tedavide en sık kullanılan kemoterapötik ajanlardan biri ise Doksorubisin (Dox) olup, tedaviye bağlı direnç nedeniyle hastaların önemli bir kısmı kaybedilmektedir. Dox direncinin yenilmesinde farklı hücre ölüm tiplerini tetikleyecek ajanların hedeflenmesi önemli bir konudur ve son zamanlarda ferroptotik yolak üzerinden kanser hücrelerinin hedeflenmesi ilgi odağı haline gelmektedir. Sonuç olarak, tedaviye dirençli kanserlerde kanser hücrelerini ölüme sürükleme potansiyeli açısından ferroptotik hücre ölüm mekanizmasının tetiklenmesi direnci yenme açısından umut verici yeni bir yaklaşım olarak değerlendirilmektedir. Bu derlemede ferroptotik hücre ölümü ve meme kanseri tedavi direnci açısından olası moleküler etki mekanizmaları gözden geçirilmiştir.

Anahtar Kelimeler

• Ferroptoz
• Meme Kanseri
• İlaç Direnci
• Kanser

Kaynakça

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