Sağlıklı Türk Çocuklarında Serum Alkalen Fosfataz Düzeylerinin Belirlenmesi

Öz

Amaç: Alkalen fosfataz (ALP), birçok dokuda bulunan bir enzimdir ve fosfat metabolizması ile kemik oluşumunda rol oynar. Bu çalışmanın amacı, yaş, cinsiyet ve pubertal evrelere göre serum ALP düzeylerini belirlemektir. Yöntem: Bu çalışma Eylül 2012-Eylül 2013 tarihleri arasında Keçiören Eğitim ve Araştırma Hastanesi Pediatri Polikliniğine rutin kontrol için başvuran çocuklarda gerçekleştirilmiştir. Çocuklarda serum Alkalen Fosfataz düzeylerini belirlemek amacıyla 1063 (511 erkek, 552 kız) çocuk çalışmaya dahil edilmiştir. Her iki cinsiyette yaşa göre serum ALP düzeylerinin dağılımı belirlenmiştir. Bulgular: Serum ALP düzeyleri, çocuklarda bebeklik döneminde en yüksek düzeylerde saptanmış, sonrasında kademeli olarak azalmış, 8 yaşından itibaren tekrar yükselmiş ve 12–14 yaşlarında yüksek seyrederek 14 yaşından sonra giderek azalmıştır. Çocukların pubertal evrelerine göre değerlendirildiğinde, her iki cinste de pubertal evre 2–3’te yüksek ALP düzeyleri görülürken, evre 4–5’te ALP düzeylerinde azalma saptanmıştır. Çocukların gelişim dönemlerine göre değerlendirildiğinde, bebeklik döneminde D vitamini eksikliği %44, okul öncesi dönemde %20, okul döneminde %31 ve adölesan dönemde %58,5 olarak bulunmuştur. Çalışmamızda cinsiyetlere göre değerlendirildiğinde, tüm yaş gruplarında erkeklerde D vitamini eksikliği %30,3, kızlarda ise %41,9 olarak tespit edilmiştir. Sonuç: ALP düzeyleri hızlı gelişim aşamalarında daha yüksek bulunmuş ve bunun pubertal evreler ile ilişkisi gösterilmiştir. Ayrıca, vitamin D eksikliği tespit edilmiş ve önemi vurgulanmıştır.

Anahtar Kelimeler

• alkalen fosfataz
• D vitamini
• çocuklar

Determination Of Serum Alkaline Phosphatase Levels In Healthy Turkish Children

Öz

Objective: Alkaline phosphatase (ALP) is an enzyme found in many tissues and plays a role in phosphate metabolism and bone formation. This study aimed to determine serum ALP levels according to age, gender, and pubertal stage. Method: This study was conducted on children with no history of chronic disease or medication who attended the pediatric outpatient clinic of Keçiören Training and Research Hospital for routine control between September 2012 and September 2013. To determine the serum Alkaline Phosphatase levels in children, 1,063 (511 male, 552 female) children were included. The ranges of serum ALP levels in both genders according to age were determined. Results: Serum ALP levels were highest in children during infancy, gradually decreased, rose again from the age of 8, remained high at 12-14 years of age, and gradually decreased after the age of 14. Regarding their pubertal stage, it was noted that ALP levels are high in both genders in stages 2-3, whereas they are decreased in stages 4-5. Regarding their childhood stage, vitamin D insufficiency was found in 44% during infancy, 20% in preschool children, 31% in school children, and 58.5% during adolescence. In our study, vitamin D deficiency was found among 30.3% of boys and 41.9% of girls across all age groups. Conclusion: ALP levels were higher during the rapid developmental stages, and their relationship with the pubertal stage was demonstrated. Additionally, vitamin D deficiency was identified, and its significance was highlighted.

Anahtar Kelimeler

• alkaline phosphatase
• vitamin D
• children

Kaynakça

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