A Review on the Antidiabetic Potential of Saffron in the Treatment of Type 2 Diabetes Mellitus and Its Research Methodologies

Yıl 2024, , 20 - 28, 31.12.2024

Nil Sazlı , Deniz Karataş

https://doi.org/10.47118/somatbd.1588884

Öz

This study is a review of the antidiabetic potential of the Saffron plant in the treatment of Type 2 Diabetes and research methodologies. The experimental design of this project study aimed to obtain crocin from the saffron plant. Crocin is considered a potential natural drug agent thanks to its high antioxidant and antidiabetic properties. However, in order to obtain the highest yield of crocin in obtaining this natural agent, it is very important to ensure optimization by selecting the right extraction techniques, phenolic content, antioxidant and antidiabetic analyses. In this project, it was aimed to apply extraction techniques under appropriate conditions to obtain crocin from the Crocus sativus plant, also known as saffron. In addition, an experimental design was created to apply HPLC to obtain high purity of crocin, TPC analysis to determine total phenolic content, ORAC and DPPH analyses to determine antioxidant capacity, and α-Amylase Inhibition Test and α-Glucosidase Inhibition Test techniques to determine antidiabetic potential. Once the desired results are achieved, experimental studies will be initiated to develop crocin into a natural market drug.

Anahtar Kelimeler

Saffron, Antidiabetic, Natural Agent, Crocin, Medicine.

Tip 2 Diyabet tedavisine yönelik Safranın Antidiyabetik Potansiyeli ve Araştırma Metodolojilerine Üzerine Derleme

Öz

Bu çalışma Tip 2 Diyabet tedavisine yönelik Safran bitkisinin antidiyabetik potansiyeli ve araştırma metodolojileri üzerine bir derlemedir. Bu proje çalışmasının deneysel tasarımında, safran bitkisinden krosin elde edilmesi amaçlanmıştır. Krosin, yüksek antioksidan ve antidiyabetik özellikleri sayesinde potansiyel bir doğal ilaç etkeni olarak görülmektedir. Ancak, bu doğal etkeni elde etmede krosinin en yüksek verimini elde etmek için, doğru ekstraksiyon tekniklerini, fenolik içeriği, antioksidan ve antidiyabetik analizleri seçerek optimizasyonu sağlamak çok önemlidir. Bu projede, safran olarak da bilinen Crocus sativus bitkisinden krosin elde etmek için uygun koşullar altında ekstraksiyon tekniklerinin uygulanması amaçlanmıştır. Ayrıca, krosinin yüksek saflığını elde etmek için HPLC, toplam fenolik içeriğini belirlemek için TPC analizi, antioksidan kapasitesini belirlemek için ORAC ve DPPH analizleri ve antidiyabetik potansiyeli belirlemek için α-Amilaz İnhibisyon Testi ve α-Glukosidaz İnhibisyon Testi tekniklerini uygulamak üzere bir deneysel tasarım oluşturulmuştur. İstenilen sonuçlar elde edildiğinde, krosinin doğal bir pazar ilacı haline getirilmesi için deneysel çalışmalar başlatılacaktır.

Anahtar Kelimeler

Safran, Antidiyabetik, Doğal İlaç, Krosin, İlaç.

Kaynakça

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