KANSER METASTAZINDA WAVE DÜZENLEYİCİ KOMPLEKSİNİN MOLEKÜLER ROLÜ: KAPSAMLI BİR GENEL BAKIŞ

Öz

Kanser metastazı, onkolojideki en büyük zorluklardan biridir ve kanser kaynaklı ölümlerin ana nedenidir. Metastatik süreç, kanser hücrelerinin aktif göçünü gerektirir ki bu da büyük ölçüde aktin sitoskeletonunun dinamik olarak yeniden düzenlenmesine bağlıdır. Bu derlemenin amacı, hücre göçünün kritik bir düzenleyicisi olan WAVE Düzenleyici Kompleksi'nin (WRC) moleküler yapısını, regülasyonunu ve kanser metastazındaki çok yönlü rolünü güncel literatür ışığında özetlemektir. WRC, Rac1 gibi sinyal moleküllerini Arp2/3 kompleksi aracılı aktin polimerizasyonuna bağlayan beş alt birimden oluşan bir komplekstir ve lamelipodyum gibi invaziv yapıların oluşumunda merkezi bir rol oynar. Literatür, WRC bileşenlerinin birçok agresif kanser türünde aşırı eksprese edildiğini ve bu durumun artan hücre invazyonu, metastaz potansiyeli ve kötü prognoz ile güçlü bir şekilde ilişkili olduğunu göstermektedir. Sonuç olarak, WRC, kanser hücrelerinin metastatik yetenek kazanmasında temel bir moleküler mekanizma olarak öne çıkmaktadır. Bu nedenle, WRC sinyal yolağının hedeflenmesi, kanserin yayılmasını önlemeye yönelik yeni anti-metastatik tedavi stratejilerinin geliştirilmesi için umut verici bir alan oluşturmaktadır.

Anahtar Kelimeler

• Aktin Hücre İskeleti
• Arp 2/3 Kompleks
• Hücre Göçü
• Kanser Metastazı
• Wave Düzenleyici Kompleks (WRC)

THE MOLECULAR ROLE OF THE WAVE REGULATORY COMPLEX IN CANCER METASTASIS: A COMPREHENSIVE OVERVIEW

Öz

Cancer metastasis is among the most critical challenges in oncology and accounts for a major share of cancer-related deaths. This progression necessitates the active motility of cancer cells, a phenomenon closely tied to the dynamic remodeling of the actin cytoskeleton. This review focuses on the molecular composition, regulatory dynamics, and diverse roles of the WAVE Regulatory Complex (WRC)—a pivotal player in cell migration—within the context of cancer dissemination, drawing upon the latest literature. Structurally, the WRC comprises five subunits that transmit signals from small GTPases such as Rac1 to the Arp2/3 complex, initiating actin polymerization. This process facilitates the formation of invasive cellular extensions like lamellipodia, which are instrumental in migratory behavior. Accumulating evidence reveals that WRC components are highly expressed in various aggressive malignancies, correlating strongly with enhanced invasion potential, increased metastatic capacity, and poor clinical outcomes. Thus, WRC-mediated signaling pathways emerge as promising therapeutic targets, potentially contributing to the design of novel anti-metastatic strategies aimed at halting cancer spread.

Anahtar Kelimeler

• Actin cytoskeleton
• Arp 2/3 Complex
• Cancer Metastasis
• Cell Migration
• Wave Regulatory Complex

Kaynakça

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