KEKİK

Yıl 2022, Cilt: 1 Sayı: 191, 15 - 31, 18.05.2022

Kemal Hüsnü Can Başer

Öz

Kekik uçucu yağında ana bileşik olarak karvakrol (veya timol) içeren muhtelif türlerinin genel adıdır. Türkiye dünyanın en çok kekik ihraç ettiği türler, ülkemizin en önemli yabani ürünüdür. Türkiye’nin kekik ihracatının büyük kısmını; (önem sırasına göre) Origanum onites (Türk kekiği, Bilyalı kekik), Origanum vulgare subsp. hirtum (= Origanum heracleoticum) (Yunan kekiği, İstanbul kekiği), Origanum minutiflorum (Yayla kekiği, Sütçüler kekiği) [endemik], Origanum dubium (Beyaz kekik), Origanum syriacum var. bevanii (Israil kekiği)’dir. Bu çalışmada Türkiye’deki kekik türlerinin özellikleri ve etkilerinin tanıtılması amaçlanmıştır.

Anahtar Kelimeler

Farmakoloji, Kekik türleri, Türkiye.

Kaynakça

• Alçiçek A, Bozkurt M, Çabuk M (2004).The effect of a mixture of herbal essential oils, an organic acid or a probiotic on broiler performance. South African Journal Animal Science, 34(4):217-222.
• Alçiçek A, Bozkurt M, Çabuk M (2003).The effect of an essential oil combination derived from selected herbs growing wild in Turkey on broiler performance, South African Journal Animal Science, 33(2): 89-94. http://doi.org/ 10.4314/sajas.v33i2.3761.
• Aydın S, Başer KHC, Öztürk Y (1997). The Chemistry and Pharmacology of Origanum (Kekik) Water, in Essential Oils: Basic and Applied Research, Proceeding of the 27th International Symposium on Essential Oils, 8-11 September 1996, Vienna, Austria, Eds. Ch.Franz, A.Mathe and G.Buchbauer, p. 52-60.
• Aydın S, Öztürk Y, Beis R, Başer KHC (1996). Investigation of Origanum onites, Sideritis congesta and Satureja cuneifolia essential oils for analgesic activity. Phytotherapy Research, 10: 342-344.
• Aykaç A, Becer E, Özbeyli D, Şener G, Başer KHC (2020). Protective Effects of Origanum onites Essential Oil in the Methotrexate-Induced Rat Model: Role on Apoptosis and Hepatoxicity. Records Natural Products, 14(6) 395-404. http://doi.org/ 10.25135/rnp186.20.04.1631.
• Aykaç A, Teralı K, Özbeyli D, Ede S, Albayrak O, Başer KHC, Şener G (2021). A Multi-Parameter Evaluation of the Neuroprotective and Cognitive-Enhancing Effects of Origanum onites L. (Turkish Oregano) Essential Oil on Scopolamine-Induced Amnestic Rats. Metabolic Brain Disease, 37(4): 1041-1055. http://doi.org/10.1007/s11011-022-00933-6
• Başer KHC (2002). The Turkish Origanum Species, In:Oregano, The Genera Origanum and Lippia, Ed.: S.E.Kintzios, Taylor and Francis, UK.
• Başer KHC (2005). New trends in the utilization of medicinal and aromatic plants, Acta Horticulturae, 676: 11-23. http://doi.org/ 10.17660/ActaHortic.2005.676.1
• Başer KHC (2008). Biological and Pharmacological Activities of Carvacrol and Carvacrol Bearing Essential Oils, Current Pharmaceutical Design, 14: 3106-3120. http://doi.org/ 10.2174/138161208786404227.
• Bostancıoğlu RB, Kürkçüoğlu M, Başer KHC, Koparal AT (2012). Assessment of anti-angiogenic and anti-tumoral potentials of Origanum onites L. essential oil, Food and Chemical Toxicology, 50(6): 2002-2008. http://doi.org/ 10.1016/j.fct.2012.03.074.
• Bozkurt M, Başer KHC (2002). The effect of antibiotic, Mannan oligosaccharide and essential oil mixture on the laying hen performance, 1st European Symposium on Bioactive Secondary Plant Products in Veterinary Medicine, 4-5 October 2002, Vienna,.
• Bozkurt M, Başer KHC (2002). The effect of commercial organic acid, probiotic and essential oil mixture at two levels on the performance of broilers, 1st European Symposium on Bioactive Secondary Plant Products in Veterinary Medicine, 5 October 2002, Vienna, Austria.
• Canbek M, Uyanoğlu M, Bayramoğlu G, Şentürk H, Erkasap N, Köken T, Uslu S, Demirüstü C, Aral E, Başer KHC (2008). Effects of carvacrol on defects of ischemia-reperfusion in the liver. Phytomedicine, 15:447-452. http:// doi.org/10.1016/j.phymed.2007.11.022.
• Carroll JF, Demirci B, Kramer M, Bernier UR, Agramonte NM, Başer KHC, Tabanca N (2017). Repellency of the Origanum onites L. essential oil and constituents to the lone star tick and yellow fever mosquito. Natural Product Research, 31(18): 2192-2197. http:// doi.org/10.1080/14786419.2017.1280485.
• Cingi M., Kırımer N, Sarıkardaşoğlu I, Cingi C, Başer KHC (1992). Pharmacological activities of the essential oils of Origanum onites and Origanum minutiflorum, In: Proceedings of the 9th Symposium on Plant Drugs, K.H.C.Başer, Ed., Eskişehir, pp. 10-15
• Coşkun S, Girişkin O, Kürkçüoğlu M, Girişkin AO, Kırımer N, Başer KHC (2008). Acaricidal efficacy of Origanum onites L. essential oil against Rhipicephalus turanicus (Ixodidae). Parasitology Research, 103: 259-261. http:// doi.org/10.1007/s00436-008-0956-x.
• Çabuk M, Bozkurt M, Alçiçek A, Akbaş Y, Küçükyılmaz K (2006). Effect of a herbal essential oil mixture on growth and internal organ weigth of broilers from young and old breeder flocks. South African Journal Animal Science, 36(2): 135-141. http:// doi.org/10.4314/sajas.v36i2.3996.
• Çabuk M, Bozkurt M, Alçiçek A, Çatlı AU, Başer KHC (2006). Effect of a dietary essential oil mixture on performance of laying hens in the summer season. South African Journal Animal Science, 36(4): 215-22.
• Demirci F, Paper DH, Franz G, Başer KHC (2004). Investigation of the Origanum onites L. Essential Oil Using the Chorioallantoic Membrane (CAM) Assay. Journal of Agricultural and Food Chemistry, 52: 251 – 254. http:// doi.org/ 10.1021/jf034850k.
• Dündar E, Olgun EG, Işıksoy S, Olgun EG, Kürkçüoğlu M, Başer KHC, Bal C (2008). The effects of intra-rectal and intra-peritoneal application of Origanum onites L. Essential oil on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat, Experimental Toxicology Pathology, 59 (6) 399-408. https://doi.org/10.1016/j.etp.2007.11.009.
• İslam A, Susever S, Yiğit Hanoğlu D, Başer KHC, Çetiner S (2021). Comparative Antibacterial Capabilities of Origanum onites oil and Diode Laser against Enterecoccus faecalis contaminated primary root canals. Cyprus Journal of Medical Sciences, 6(3): 237-243. http:// doi.org/ 10.5152/cjms.2021.1136. Karadağlıoğlu Öİ, Ulusoy N, Başer KHC, Hanoğlu A, Şık İ (2019). Antibacterial Activities of Herbal Toothpastes Combined with Essential Oils against Streptococcus mutans. Pathogens, 8(1): 20. http:// doi.org/10.3390/pathogens8010020.
• Khan I, Bahuguna A, Kumar P, Bajpai V K, Kan SC (2018). In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis. Nature Scientific Reports, 8(1):144. http:// doi.org/10.1038/s41598-017-18644-9.
• Lukas B, Samuel R, Mader E, Başer, KHC, Duman H, Novak J (2013). Complex evolutionary relationships in the Origanum L. section Majorana Benth. (Lamiaceae). Botanical Journal of Linnean Society, 171: 667-686
• Özdemir B, Ekbul A, Topal NB, Sarandol E, Sağ A, Başer KHC, Cordan J, Güllülü S, Tuncel E, Baran I, Aydınlar A (2008). Effects of Origanum onites on endothelial function and serum biochemical markers in hyperlipidaemic patients. Journal of International Mediderrenaen Research, 36(6); 1326-1334. http:// doi.org/ 10.1177/147323000803600621.
• Özkum D, Kürkçüoğlu M, Tıpırdamaz R, Başer KHC (2010). Essential oils from wild and micropropagated plants of Origanum minutiflorum O. Schwarz et Davis. Journal of Essential Oil Researh, 22, 135-137 (2010). http:// doi.org/ 10.1080/10412905.2010.9700284
• Taşdemir D, Kaiser M, Demirci B, Demirci F, Başer KHC (2019). Antiprotozoal Activity of Turkish Origanum onites Essential Oil and Its Components. Molecules, 24(23):4421. http:// doi.org/10.3390/molecules24234421
• Tınmaz AB, Başer KHC, Karık Ü, Kürkçüoğlu M, Öztürk M (2009). Determination of Quality Specifications of Origanum vulgare subsp. hirtum Populations Growing in Marmara Region of Turkey, Acta Horticulturae, 826: 153-158.
• Ultee A, Kets EPW, Smid EJ (1999), Mechanisms of action of carvacrol in the food-borne pathogen Bacillus cereus. Applied and Environmental Microbiology, 65(10): 4606-4610. http:// doi.org/ 10.1128/aem.65.10.4606-4610.1999.
• Uyanoğlu M, Canbek M, Aral E, Başer KHC (2008). Effects of carvacrol upon the liver of rats undergoing partial hepatectomy. Phytomedicine, 15(3): 226-229. http:// doi.org/ 10.1016/j.phymed.2007.06.010.
• Zeytinoğlu H, Incesu Z, Başer KHC (2003). Inhibition of DNA synthesis by carvacrol in mouse myoblast cells bearing a human N-Ras oncogene. Phytomedicine, 10(4): 292-299. http:// doi.org/10.1078/094471103322004785.
• Zeytinoğlu M, Aydın S, Öztürk Y, Başer KHC (1998). Inhibitory Effects of Carvacrol n DMBA Induced Pulmonary Tumorigenesis in Rats, Acta Pharmaceutica Turcica, 40(2): 93-98.