Çocukluk Çağı Akut Myeloid Lösemilerde Kan Ürünü Kullanımının Kemoterapi Bloklarına Göre Dağılımı

Yıl 2020, Cilt: 14 Sayı: 6, 507 - 511, 30.11.2020

Elif Güdeloğlu Davut Albayrak Canan Albayrak

https://doi.org/10.12956/tchd.587123

Öz

Amaç:
Bu çalışmada; akut myeloblastik lösemi (AML) tanısı ile kemoterapi blokları
alan çocuk hastalara verilmiş olan toplam eritrosit, random trombosit ve aferez
trombosit süspansiyonun, hastanın o dönemde almış olduğu kemoterapi (KT) bloğu
ile olan ilişkisi değerlendirilmiştir.

Gereç
ve Yöntemler: AML tanısı
ile takip edilen toplam 146 hastanın transfüzyon ihtiyacı, hastaların kan
bankası verilerine girilerek tedavi 
süresince,  torba sayısı ve tipi
olarak eritrosit, random trombosit ve trombosit süspansiyonu olarak belirlendi.

Bulgular:
Toplam
37 hastanın tanı konulduğu andan tedavinin bittiği döneme kadarki süreçte hasta
başı ortalama toplam eritrosit kullanımı 27 (10-102) adetti. KT blokları
esnasında hem eritrosit hem de aferez trombosit kullanımının en fazla olduğu
blok Aie bloğu idi. Bu blokta ki ortalama kişi başı eritrosit kullanımı  8 (2-20) adet iken, aferez trombosit
kullanımı 8,5 (1-28) adet olarak saptanmıştır. Random trombosit kullanım adeti
ise kişi başı ortalama 20 (7-139) adet iken, en fazla random trombosit kullanılan
KT bloğu olan İdame’de ki ortalama kişi başı random trombosit kullanım adeti 27
(1-102) olarak saptanmıştır.

Sonuç: AML’li
çocuklarda KT süresince çok sayıda kan ve kan ürünü transfüzyonu gereklidir. Bu
transfüzyonun etkinliği akut löseminin tipine, hastanın yaşına, cinsiyetine,
hastanın aldığı KT bloğu ile o dönem aldığı KT ilaçlarına ya da hastanın o
dönemde ki enfeksiyon, sepsis, yaygın tüketim koagulopatisi gibi klinik bir
tabloda olup olmaması gibi çok sayıda etkene bağlı olabilir.

Anahtar Kelimeler

Akut myeloblastik lösemi, Çocuk, Kemoterapi, Transfüzyon

Blood Product Requirement in Childhood Acute Myeloid Leukemia by Chemotherapy Regimens

Öz

Aim: This study evaluates the association of total
erythrocyte, random platelet and apheresis platelet suspension given to
children receiving chemotherapy (CT) blocks with a diagnosis of acute
myeloblastic leukemia (AML) with the chemotherapy (CT) block the patient
received in that period.

Material and Methods: The transfusion need of a total of 146 patients
followed with a diagnosis of AML were determined as erythrocyte, random
platelet and platelet suspension as number and type in bags from the moment the
patients were diagnosed to the period the treatment ended by entering the blood
bank data base records.

Results: The number of total per patient average erythrocyte
use of a total of 37 patients during the process from the moment they were diagnosed to the period the
treatment ended was 27 (100-102). Of the CT blocks, the block in which both
erythrocyte and apheresis platelet use was the highest was Aie block. While the
average per person erythrocyte use was 8
(2-20) in this block, apheresis platelet use was found as 8,5 (1-28). While the
number of average per person random platelet use was 20 (7-139), the number of
average per person random platelet use was as 27 (1-102) in the Maintenance
block, which is the CT block in which the most random platelet was used.

Conclusion: In children with
AML, a great number of blood and blood product transfusions are needed
during CT. The efficiency of these transfusions can depend on a great number of
factors such as the type of acute leukemia, patient age, patient gender, the CT
block the patient is receiving, the CT drugs the patient is receiving in that
period and whether the patient has a clinical picture such as infection,
sepsis, intense consumption coagulopathy during that period. 

Anahtar Kelimeler

Acute myeloblastic leukemia, child, chemotherapy, Transfusion, Blood

Kaynakça

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