Potential Effects of Propolis Against Coronaviruses

Abstract

Throughout human history, many diseases are caused by viruses. Researchers are working on vaccines against viruses and these vaccines are widely used as protective material. Due to virus dynamics, new variants emerge as a result of mutations in different types of hosts from time to time. These variants can threaten human life by bypassing the unprepared immune system of the infected individual. Fortunately, our body has an immune system that can renew itself and works flawlessly against these viruses. The newly formed variant, which is not limited to the known, can also generate immunity against the genetic structure of the virus. In defense against viral infections, the limited effects of antivirals, the time-consuming need for vaccine production to be provided to the infected, and applications that strengthen the immune system come to the fore. In this context, if our immune system is supported and stimulated with natural, functional products such as propolis, it will be able to fight viruses more effectively. Propolis shows that it is a remarkable product in the fight against viruses with its modulations in the immune system against the SARS CoV-2 epidemic that swept the world, its PAK-1 blocker effect, early and higher immunity stimulation, increased antibody titers, and immunomodulatory effects such as prolonging the duration of immune protection. From this point of view, in this review article, we discussed the effects of propolis, known as a bee product that activates the immune system and facilitates the functioning of the immune system, against coronaviruses.

Keywords

• Coronavirus
• Propolis
• Immuno modulation

Propolisin Koronavirüslere Karşı Potansiyel Etkileri

Öz

İnsanlık tarihi boyunca birçok hastalık virüs kaynaklı olarak meydana gelmektedir. Araştırmacılar virüslere karşı aşı çalışması yapmakta ve koruyucu materyal olarak bu aşılar yaygın olarak kullanılmaktadır. Virüs, dinamiği gereği farklı tür konaklarda zaman zaman mutasyona uğramaları sonucu yeni varyantlar ortaya çıkmaktadır. Bu varyantlar enfekte ettiği bireyin hazırlıksız olan bağışıklık sistemini atlatarak insan hayatını tehdit eder duruma gelebilmektedir. Neyse ki bu virüslere karşı, vücudumuzda kendini yenileyebilme özelliği olan ve kusursuz çalışan bir immün sistem vardır ki sadece bilinenle sınırlı kalmayan, yeni oluşan varyant virüsün genetik yapısına karşı da bağışıklık üretebilmektedir. Viral enfeksiyonlara karşı savunmada, antivirallerin sınırlı etkileri, aşı üretiminin enfekte olanlara sağlanmasının zaman alması, bağışıklık sistemini güçlendirici uygulamaları ön plana çıkartmaktadır. Bu bağlamda bağışıklık sistemimiz, propolis gibi doğal, fonksiyonel ürünler ile desteklenir ve uyarılırsa virüslere karşı daha etkili bir savaş verebilecektir. Propolis, Dünyayı saran SARS CoV-2 salgınına karşı immün sistemde yaptığı modülasyonlarla, PAK-1 bloker etkisi, erken ve daha yüksek bağışıklığın uyarılması, antikor titrelerinin yükseltilmesi, bağışıklık koruma süresinin uzatılması gibi immünmodülatör etkilere sahip olması ile virüslerle mücadelede dikkat çekici bir ürün olduğunu göstermektedir. Bu noktadan hareketle bu derleme makalesinde bağışıklık sistemini harekete geçiren ve bağışıklık sisteminin çalışmasını kolaylaştıran bir arı ürünü olarak bilinen propolisin kullanımında koronavirüslere karşı etkilerinin neler olabileceğini tartıştık.

Anahtar Kelimeler

• Koronavirüs,
• propolis,
• İmmüno modülasyon

Kaynakça

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