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Aurora Kinases: Their Role in Cancer and Cellular Processes

Yıl 2024, Cilt: 13 Sayı: 2, 128 - 139, 28.06.2024
https://doi.org/10.46810/tdfd.1476374

Öz

Aurora kinases, belonging to a highly conserved family of serine/threonine kinases with critical roles in the regulation of the cell cycle, comprise three members: Aurora kinase A, B, and C, which serve as key mitotic regulators essential for maintaining chromosome stability. Aurora kinases play crucial roles in multiple events in mitotic such as the coordination of chromosomal and cytoskeletal events, regulation of the spindle assembly checkpoint pathway and cytokinesis to ensure the smooth progression of the cell cycle. Besides their mitotic functions, Aurora kinases are also involved in the regulation of meiosis. Gene amplification/mutation and overexpression of Aurora kinases have been detected in various solid and haematological cancers. In human tumours, Aurora kinases exhibit oncogenic roles associated with their mitotic roles, which drive the cancer cell proliferation and survival. Deregulation of Aurora kinase activity causes failure in centrosome function, spindle assembly, chromosomal alignment, and cytokinesis, eventually resulting in the mitotic abnormalities and genetic instability. These findings emphasize the crucial functions of Aurora kinases in cancer, prompting their recognition as valuable targets for cancer therapy. This review provides an overview of the structures and functions of Aurora kinases and sheds light on their oncogenic roles in cancer.

Kaynakça

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AURORA KİNAZLARIN KANSER VE HÜCRESEL SÜREÇLERDEKİ ROLÜ

Yıl 2024, Cilt: 13 Sayı: 2, 128 - 139, 28.06.2024
https://doi.org/10.46810/tdfd.1476374

Öz

Aurora kinazlar, Aurora A, B ve C şeklinde tanımlanan üç üyeye sahip, hücre döngüsünün düzenlenmesinde kritik rolleri olan yüksek oranda korunmuş serin/treonin kinaz ailesine ait proteinlerdir. Aurora kinazlar, kromozom stabilitesinin korunmasında önemli rolleri olan mitotik düzenleyiciler olarak hizmet etmektedir. Mitozdaki çeşitli olaylarda kritik roller üstlenen Aurora kinazlar, kromozomal ve sitoskeletal olayların koordinasyonu, iğ ipliği oluşumu kontrolü ve sitokinez gibi olaylarda görev alarak hücre döngüsünün sorunsuz ilerlemesini sağlamaktadır. Mitotik fonksiyonlarının yanı sıra, Aurora kinazlar mayoz bölünmenin düzenlenmesi süreçlerinde de yer almaktadırlar. Aurora kinazların gen amplifikasyonu/mutasyonu ve aşırı ifadesi çeşitli solid ve hematolojik kanserlerde tespit edilmiştir. Aurora kinazlar mitotik rolleri ile ilişkilendirilen onkojenik fonksiyonları ile kanser hücrelerinin çoğalması ve hayatta kalmalarını sağlamaktadırlar. Aurora kinaz aktivitesinin bozulması, sentrozom fonksiyonunda, iğ ipliklerinin oluşumunda, kromozomal hizalanmada ve sitokinezde sorunlara neden olarak mitotik anormallikler ve genetik istikrarsızlığa yol açmaktadır. Bu bulgular, Aurora kinazların kanserdeki önemli fonksiyonlarını vurgulayarak kanser terapötikleri için değerli hedefler olarak tanınmalarını sağlamaktadır. Bu derleme, Aurora kinazların yapı ve fonksiyonlarına genel bir bakış sunarak, bu kinazların kanserdeki onkojenik rollerini aydınlatmaktadır.

Etik Beyan

Çalışmamız için Etik Kurul Belgesine İhtiyaç Yoktur.

Kaynakça

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  • Shammas MA. Telomeres, lifestyle, cancer, and aging. Curr Opin Clin Nutr Metab Care 2011;14:28–34. https://doi.org/10.1097/MCO.0b013e32834121b1.
  • Umene K, Banno K, Kisu I, Yanokura M, Nogami Y, Tsuji K, et al. Aurora kinase inhibitors: Potential molecular-targeted drugs for gynecologic malignant tumors. Biomed Rep 2013;1:335–40. https://doi.org/10.3892/br.2013.91.
  • Cirak Y, Furuncuoglu Y, Yapicier O, Aksu A, Cubukcu E. Aurora A overexpression in breast cancer patients induces taxane resistance and results in worse prognosis. J BUON 2015;20:1414–9.
  • Hole S, Pedersen AM, Lykkesfeldt AE, Yde CW. Aurora kinase A and B as new treatment targets in aromatase inhibitor-resistant breast cancer cells. Breast Cancer Res Treat 2015;149:715–26. https://doi.org/10.1007/s10549-015-3284-8.
  • Sun J-M, Yang L-N, Xu H, Chang B, Wang H-Y, Yang G. Inhibition of Aurora A promotes chemosensitivity via inducing cell cycle arrest and apoptosis in cervical cancer cells. Am J Cancer Res 2015;5:1133–45.
  • Gabrielli B, Bokhari F, Ranall MV, Oo ZY, Stevenson AJ, Wang W, et al. Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer. Mol Cancer Ther 2015;14:2753–61. https://doi.org/10.1158/1535-7163.MCT-15-0506.
  • Casorzo L, Dell’Aglio C, Sarotto I, Risio M. Aurora kinase A gene copy number is associated with the malignant transformation of colorectal adenomas but not with the serrated neoplasia progression. Human Pathology 2015;46:411–8. https://doi.org/10.1016/j.humpath.2014.11.016.
  • Saiprasad G, Chitra P, Manikandan R, Sudhandiran G. Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis. Eur J Cancer 2014;50:2489–507. https://doi.org/10.1016/j.ejca.2014.06.013.
  • Jin S, Wang X, Tong T, Zhang D, Shi J, Chen J, et al. Aurora‐A enhances malignant development of esophageal squamous cell carcinoma (ESCC) by phosphorylating β‐catenin. Mol Oncol 2015;9:249–59. https://doi.org/10.1016/j.molonc.2014.08.002.
  • Wang X, Li X, Li C, He C, Ren B, Deng Q, et al. Aurora-A modulates MMP-2 expression via AKT/NF-κB pathway in esophageal squamous cell carcinoma cells. Acta Biochim Biophys Sin (Shanghai) 2016;48:520–7. https://doi.org/10.1093/abbs/gmw030.
  • Honma K, Nakanishi R, Nakanoko T, Ando K, Saeki H, Oki E, et al. Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers. Surg Today 2014;44:454–61. https://doi.org/10.1007/s00595-013-0581-x.
  • Katsha A, Belkhiri A, Goff L, El-Rifai W. Aurora kinase A in gastrointestinal cancers: time to target. Mol Cancer 2015;14:106. https://doi.org/10.1186/s12943-015-0375-4.
  • Premkumar DR, Jane EP, Pollack IF. Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells. Cancer Biol Ther 2015;16:233–43. https://doi.org/10.4161/15384047.2014.987548.
  • Reichardt W, Jung V, Brunner C, Klein A, Wemmert S, Romeike BFM, et al. The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas. Oncology Reports 2003;10:1275–9. https://doi.org/10.3892/or.10.5.1275.
  • Kim S-J, Jang JE, Cheong J-W, Eom J-I, Jeung H-K, Kim Y, et al. Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells. Korean J Hematol 2012;47:178–85. https://doi.org/10.5045/kjh.2012.47.3.178.
  • Wei T-YW, Wu P-Y, Wu T-J, Hou H-A, Chou W-C, Teng C-LJ, et al. Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA. Cancer Res 2017;77:494–508. https://doi.org/10.1158/0008-5472.CAN-16-1004.
  • Lo Iacono M, Monica V, Saviozzi S, Ceppi P, Bracco E, Papotti M, et al. Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation. J Transl Med 2011;9:100. https://doi.org/10.1186/1479-5876-9-100.
  • Gu J, Gong Y, Huang M, Lu C, Spitz MR, Wu X. Polymorphisms of STK15 (Aurora-A) gene and lung cancer risk in Caucasians. Carcinogenesis 2007;28:350–5. https://doi.org/10.1093/carcin/bgl149.
  • Tatsuka M, Sato S, Kitajima S, Suto S, Kawai H, Miyauchi M, et al. Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis. Oncogene 2005;24:1122–7. https://doi.org/10.1038/sj.onc.1208293.
  • Tanaka H, Nakashiro K, Iwamoto K, Tokuzen N, Fujita Y, Shirakawa R, et al. Targeting Aurora kinase A suppresses the growth of human oral squamous cell carcinoma cells in vitro and in vivo. Oral Oncol 2013;49:551–9. https://doi.org/10.1016/j.oraloncology.2013.02.002.
  • Do T-V, Xiao F, Bickel LE, Klein-Szanto AJ, Pathak HB, Hua X, et al. Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion. Oncogene 2014;33:539–49. https://doi.org/10.1038/onc.2012.632.
  • Davidson B, Nymoen DA, Elgaaen BV, Staff AC, Tropé CG, Kærn J, et al. BUB1 mRNA is significantly co-expressed with AURKA and AURKB mRNA in advanced-stage ovarian serous carcinoma. Virchows Arch 2014;464:701–7. https://doi.org/10.1007/s00428-014-1577-7.
  • Toughiri R, Li X, Du Q, Bieberich CJ. Phosphorylation of NuMA by Aurora-A kinase in PC-3 prostate cancer cells affects proliferation, survival, and interphase NuMA localization. J Cell Biochem 2013;114:823–30. https://doi.org/10.1002/jcb.24421.
  • Lee ECY, Frolov A, Li R, Ayala G, Greenberg NM. Targeting Aurora kinases for the treatment of prostate cancer. Cancer Res 2006;66:4996–5002. https://doi.org/10.1158/0008-5472.CAN-05-2796.
  • Zhang Y, Jiang C, Li H, Lv F, Li X, Qian X, et al. Elevated Aurora B expression contributes to chemoresistance and poor prognosis in breast cancer. Int J Clin Exp Pathol 2015;8:751–7.
  • Twu N-F, Yuan C-C, Yen M-S, Lai C-R, Chao K-C, Wang P-H, et al. Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer. Eur J Obstet Gynecol Reprod Biol 2009;142:57–63. https://doi.org/10.1016/j.ejogrb.2008.09.012.
  • Tuncel H, Shimamoto F, Kaneko Guangying Qi H, Aoki E, Jikihara H, Nakai S, et al. Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer. Oncol Lett 2012;3:1109–14. https://doi.org/10.3892/ol.2012.633.
  • Subramaniyan B, Kumar V, Mathan G. Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells. Biomed Pharmacother 2017;90:402–13. https://doi.org/10.1016/j.biopha.2017.03.086.
  • Diaz RJ, Golbourn B, Shekarforoush M, Smith CA, Rutka JT. Aurora kinase B/C inhibition impairs malignant glioma growth in vivo. J Neurooncol 2012;108:349–60. https://doi.org/10.1007/s11060-012-0835-2.
  • Hartsink-Segers SA, Zwaan CM, Exalto C, Luijendijk MWJ, Calvert VS, Petricoin EF, et al. Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target. Leukemia 2013;27:560–8. https://doi.org/10.1038/leu.2012.256.
  • Takeshita M, Koga T, Takayama K, Ijichi K, Yano T, Maehara Y, et al. Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer. Lung Cancer 2013;80:85–90. https://doi.org/10.1016/j.lungcan.2012.12.018.
  • Smith SL, Bowers NL, Betticher DC, Gautschi O, Ratschiller D, Hoban PR, et al. Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability. Br J Cancer 2005;93:719–29. https://doi.org/10.1038/sj.bjc.6602779.
  • Pannone G, Hindi S a. H, Santoro A, Sanguedolce F, Rubini C, Cincione RI, et al. Aurora B expression as a prognostic indicator and possible therapeutic target in oral squamous cell carcinoma. Int J Immunopathol Pharmacol 2011;24:79–88. https://doi.org/10.1177/039463201102400110.
  • Chen Y-J, Chen C-M, Twu N-F, Yen M-S, Lai C-R, Wu H-H, et al. Overexpression of Aurora B is associated with poor prognosis in epithelial ovarian cancer patients. Virchows Arch 2009;455:431–40. https://doi.org/10.1007/s00428-009-0838-3.
  • Fadri-Moskwik M, Weiderhold KN, Deeraksa A, Chuang C, Pan J, Lin S-H, et al. Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells. FASEB J 2012;26:4057–67. https://doi.org/10.1096/fj.12-206656.
  • Zekri A, Lesan V, Ghaffari SH, Tabrizi MH, Modarressi MH. Gene amplification and overexpression of Aurora-C in breast and prostate cancer cell lines. Oncol Res 2012;20:241–50. https://doi.org/10.3727/096504013x13589503482978.
  • Fujii S, Srivastava V, Hegde A, Kondo Y, Shen L, Hoshino K, et al. Regulation of AURKC expression by CpG island methylation in human cancer cells. Tumor Biol 2015;36:8147–58. https://doi.org/10.1007/s13277-015-3553-5.
  • Tsou J-H, Chang K-C, Chang-Liao P-Y, Yang S-T, Lee C-T, Chen Y-P, et al. Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells. J Pathol 2011;225:243–54. https://doi.org/10.1002/path.2934.
  • Hosseini S, Hashemzadeh S, Estiar MA, Ebrahimzadeh R, Fakhree MBA, Yousefi B, et al. Expression Analysis of Aurora-C and Survivin, Two Testis-Specific Genes, in Patients with Colorectal Cancer. Clin Lab 2015;61:475–80. https://doi.org/10.7754/clin.lab.2014.141017.
Toplam 115 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sinyal İletimi, Biyokimya ve Hücre Biyolojisi (Diğer)
Bölüm Makaleler
Yazarlar

Sibel Sarı 0000-0002-2505-5804

Elif Rumeysa Özsoy 0009-0008-6040-9875

Erken Görünüm Tarihi 28 Haziran 2024
Yayımlanma Tarihi 28 Haziran 2024
Gönderilme Tarihi 30 Nisan 2024
Kabul Tarihi 14 Mayıs 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 13 Sayı: 2

Kaynak Göster

APA Sarı, S., & Özsoy, E. R. (2024). Aurora Kinases: Their Role in Cancer and Cellular Processes. Türk Doğa Ve Fen Dergisi, 13(2), 128-139. https://doi.org/10.46810/tdfd.1476374
AMA Sarı S, Özsoy ER. Aurora Kinases: Their Role in Cancer and Cellular Processes. TDFD. Haziran 2024;13(2):128-139. doi:10.46810/tdfd.1476374
Chicago Sarı, Sibel, ve Elif Rumeysa Özsoy. “Aurora Kinases: Their Role in Cancer and Cellular Processes”. Türk Doğa Ve Fen Dergisi 13, sy. 2 (Haziran 2024): 128-39. https://doi.org/10.46810/tdfd.1476374.
EndNote Sarı S, Özsoy ER (01 Haziran 2024) Aurora Kinases: Their Role in Cancer and Cellular Processes. Türk Doğa ve Fen Dergisi 13 2 128–139.
IEEE S. Sarı ve E. R. Özsoy, “Aurora Kinases: Their Role in Cancer and Cellular Processes”, TDFD, c. 13, sy. 2, ss. 128–139, 2024, doi: 10.46810/tdfd.1476374.
ISNAD Sarı, Sibel - Özsoy, Elif Rumeysa. “Aurora Kinases: Their Role in Cancer and Cellular Processes”. Türk Doğa ve Fen Dergisi 13/2 (Haziran 2024), 128-139. https://doi.org/10.46810/tdfd.1476374.
JAMA Sarı S, Özsoy ER. Aurora Kinases: Their Role in Cancer and Cellular Processes. TDFD. 2024;13:128–139.
MLA Sarı, Sibel ve Elif Rumeysa Özsoy. “Aurora Kinases: Their Role in Cancer and Cellular Processes”. Türk Doğa Ve Fen Dergisi, c. 13, sy. 2, 2024, ss. 128-39, doi:10.46810/tdfd.1476374.
Vancouver Sarı S, Özsoy ER. Aurora Kinases: Their Role in Cancer and Cellular Processes. TDFD. 2024;13(2):128-39.