Aurora Kinases: Their Role in Cancer and Cellular Processes

Sibel Sarı; Elif Rumeysa Özsoy

doi:10.46810/tdfd.1476374

Derleme

Aurora Kinases: Their Role in Cancer and Cellular Processes

Yıl 2024, Cilt: 13 Sayı: 2, 128 - 139, 28.06.2024

Sibel Sarı , Elif Rumeysa Özsoy

https://doi.org/10.46810/tdfd.1476374

Öz

Aurora kinases, belonging to a highly conserved family of serine/threonine kinases with critical roles in the regulation of the cell cycle, comprise three members: Aurora kinase A, B, and C, which serve as key mitotic regulators essential for maintaining chromosome stability. Aurora kinases play crucial roles in multiple events in mitotic such as the coordination of chromosomal and cytoskeletal events, regulation of the spindle assembly checkpoint pathway and cytokinesis to ensure the smooth progression of the cell cycle. Besides their mitotic functions, Aurora kinases are also involved in the regulation of meiosis. Gene amplification/mutation and overexpression of Aurora kinases have been detected in various solid and haematological cancers. In human tumours, Aurora kinases exhibit oncogenic roles associated with their mitotic roles, which drive the cancer cell proliferation and survival. Deregulation of Aurora kinase activity causes failure in centrosome function, spindle assembly, chromosomal alignment, and cytokinesis, eventually resulting in the mitotic abnormalities and genetic instability. These findings emphasize the crucial functions of Aurora kinases in cancer, prompting their recognition as valuable targets for cancer therapy. This review provides an overview of the structures and functions of Aurora kinases and sheds light on their oncogenic roles in cancer.

Anahtar Kelimeler

Aurora kinases, serine/threonine kinases, cancer, cell cycle regulators, oncogenes

Kaynakça

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AURORA KİNAZLARIN KANSER VE HÜCRESEL SÜREÇLERDEKİ ROLÜ

Yıl 2024, Cilt: 13 Sayı: 2, 128 - 139, 28.06.2024

Sibel Sarı , Elif Rumeysa Özsoy

https://doi.org/10.46810/tdfd.1476374

Öz

Aurora kinazlar, Aurora A, B ve C şeklinde tanımlanan üç üyeye sahip, hücre döngüsünün düzenlenmesinde kritik rolleri olan yüksek oranda korunmuş serin/treonin kinaz ailesine ait proteinlerdir. Aurora kinazlar, kromozom stabilitesinin korunmasında önemli rolleri olan mitotik düzenleyiciler olarak hizmet etmektedir. Mitozdaki çeşitli olaylarda kritik roller üstlenen Aurora kinazlar, kromozomal ve sitoskeletal olayların koordinasyonu, iğ ipliği oluşumu kontrolü ve sitokinez gibi olaylarda görev alarak hücre döngüsünün sorunsuz ilerlemesini sağlamaktadır. Mitotik fonksiyonlarının yanı sıra, Aurora kinazlar mayoz bölünmenin düzenlenmesi süreçlerinde de yer almaktadırlar. Aurora kinazların gen amplifikasyonu/mutasyonu ve aşırı ifadesi çeşitli solid ve hematolojik kanserlerde tespit edilmiştir. Aurora kinazlar mitotik rolleri ile ilişkilendirilen onkojenik fonksiyonları ile kanser hücrelerinin çoğalması ve hayatta kalmalarını sağlamaktadırlar. Aurora kinaz aktivitesinin bozulması, sentrozom fonksiyonunda, iğ ipliklerinin oluşumunda, kromozomal hizalanmada ve sitokinezde sorunlara neden olarak mitotik anormallikler ve genetik istikrarsızlığa yol açmaktadır. Bu bulgular, Aurora kinazların kanserdeki önemli fonksiyonlarını vurgulayarak kanser terapötikleri için değerli hedefler olarak tanınmalarını sağlamaktadır. Bu derleme, Aurora kinazların yapı ve fonksiyonlarına genel bir bakış sunarak, bu kinazların kanserdeki onkojenik rollerini aydınlatmaktadır.

Anahtar Kelimeler

Aurora kinazlar, serin/treonin kinazlar, kanser, hücre döngüsü düzenleyicileri, onkogenler

Etik Beyan

Çalışmamız için Etik Kurul Belgesine İhtiyaç Yoktur.

Kaynakça

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Wang X, Li X, Li C, He C, Ren B, Deng Q, et al. Aurora-A modulates MMP-2 expression via AKT/NF-κB pathway in esophageal squamous cell carcinoma cells. Acta Biochim Biophys Sin (Shanghai) 2016;48:520–7. https://doi.org/10.1093/abbs/gmw030.
Honma K, Nakanishi R, Nakanoko T, Ando K, Saeki H, Oki E, et al. Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers. Surg Today 2014;44:454–61. https://doi.org/10.1007/s00595-013-0581-x.
Katsha A, Belkhiri A, Goff L, El-Rifai W. Aurora kinase A in gastrointestinal cancers: time to target. Mol Cancer 2015;14:106. https://doi.org/10.1186/s12943-015-0375-4.
Premkumar DR, Jane EP, Pollack IF. Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells. Cancer Biol Ther 2015;16:233–43. https://doi.org/10.4161/15384047.2014.987548.
Reichardt W, Jung V, Brunner C, Klein A, Wemmert S, Romeike BFM, et al. The putative serine/threonine kinase gene STK15 on chromosome 20q13.2 is amplified in human gliomas. Oncology Reports 2003;10:1275–9. https://doi.org/10.3892/or.10.5.1275.
Kim S-J, Jang JE, Cheong J-W, Eom J-I, Jeung H-K, Kim Y, et al. Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells. Korean J Hematol 2012;47:178–85. https://doi.org/10.5045/kjh.2012.47.3.178.
Wei T-YW, Wu P-Y, Wu T-J, Hou H-A, Chou W-C, Teng C-LJ, et al. Aurora A and NF-κB Survival Pathway Drive Chemoresistance in Acute Myeloid Leukemia via the TRAF-Interacting Protein TIFA. Cancer Res 2017;77:494–508. https://doi.org/10.1158/0008-5472.CAN-16-1004.
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Tatsuka M, Sato S, Kitajima S, Suto S, Kawai H, Miyauchi M, et al. Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis. Oncogene 2005;24:1122–7. https://doi.org/10.1038/sj.onc.1208293.
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Do T-V, Xiao F, Bickel LE, Klein-Szanto AJ, Pathak HB, Hua X, et al. Aurora kinase A mediates epithelial ovarian cancer cell migration and adhesion. Oncogene 2014;33:539–49. https://doi.org/10.1038/onc.2012.632.
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Hosseini S, Hashemzadeh S, Estiar MA, Ebrahimzadeh R, Fakhree MBA, Yousefi B, et al. Expression Analysis of Aurora-C and Survivin, Two Testis-Specific Genes, in Patients with Colorectal Cancer. Clin Lab 2015;61:475–80. https://doi.org/10.7754/clin.lab.2014.141017.

Toplam 115 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Sinyal İletimi, Biyokimya ve Hücre Biyolojisi (Diğer)
Bölüm	Makaleler
Yazarlar	Sibel Sarı 0000-0002-2505-5804 Elif Rumeysa Özsoy 0009-0008-6040-9875
Erken Görünüm Tarihi	28 Haziran 2024
Yayımlanma Tarihi	28 Haziran 2024
Gönderilme Tarihi	30 Nisan 2024
Kabul Tarihi	14 Mayıs 2024
Yayımlandığı Sayı	Yıl 2024 Cilt: 13 Sayı: 2

Kaynak Göster

APA	Sarı, S., & Özsoy, E. R. (2024). Aurora Kinases: Their Role in Cancer and Cellular Processes. Türk Doğa Ve Fen Dergisi, 13(2), 128-139. https://doi.org/10.46810/tdfd.1476374
AMA	Sarı S, Özsoy ER. Aurora Kinases: Their Role in Cancer and Cellular Processes. TDFD. Haziran 2024;13(2):128-139. doi:10.46810/tdfd.1476374
Chicago	Sarı, Sibel, ve Elif Rumeysa Özsoy. “Aurora Kinases: Their Role in Cancer and Cellular Processes”. Türk Doğa Ve Fen Dergisi 13, sy. 2 (Haziran 2024): 128-39. https://doi.org/10.46810/tdfd.1476374.
EndNote	Sarı S, Özsoy ER (01 Haziran 2024) Aurora Kinases: Their Role in Cancer and Cellular Processes. Türk Doğa ve Fen Dergisi 13 2 128–139.
IEEE	S. Sarı ve E. R. Özsoy, “Aurora Kinases: Their Role in Cancer and Cellular Processes”, TDFD, c. 13, sy. 2, ss. 128–139, 2024, doi: 10.46810/tdfd.1476374.
ISNAD	Sarı, Sibel - Özsoy, Elif Rumeysa. “Aurora Kinases: Their Role in Cancer and Cellular Processes”. Türk Doğa ve Fen Dergisi 13/2 (Haziran 2024), 128-139. https://doi.org/10.46810/tdfd.1476374.
JAMA	Sarı S, Özsoy ER. Aurora Kinases: Their Role in Cancer and Cellular Processes. TDFD. 2024;13:128–139.
MLA	Sarı, Sibel ve Elif Rumeysa Özsoy. “Aurora Kinases: Their Role in Cancer and Cellular Processes”. Türk Doğa Ve Fen Dergisi, c. 13, sy. 2, 2024, ss. 128-39, doi:10.46810/tdfd.1476374.
Vancouver	Sarı S, Özsoy ER. Aurora Kinases: Their Role in Cancer and Cellular Processes. TDFD. 2024;13(2):128-39.

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