Distinct morphological and immunohistochemical features in schwannomas and report of a case with osseous metaplasia

Öz

Background: The sections from a thoracolomber mass

Anahtar Kelimeler

• Schwannoma, osseous metaplasia, glial fibrillary acidic protein

Schwannoma’larda farklı morfolojik ve immun dokukimyasal özellikler ile osseöz metaplazi gösteren bir olgunun sunumu

Öz

Amaç: Elli yaşındaki erkek hastanın schwannoma tanısı alan spinal kitlesinin kesitlerinde fokal osseöz metaplazi saptanması üzerine, schwannoma olgularımızın histomorfolojik ve immündokukimyasal özelliklerinin retrospektif olarak incelenmesi amaçlanmıştır. Yöntem: 2002-2005 yılları arasında Karaelmas of schwannoma retrospectively Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı’nda tanı almış dokuz schwannoma olgusunun preparatları Methods

Anahtar Kelimeler

• Schwannoma, osseöz metaplazi

Kaynakça

1. Ackerman’s Surgical Pathology, 9th edition. Edinburgh:
2. Mosby; 2004. p. 2237-371. 2. Weiss SW, Goldblum JR. Benign tumors of peripheral
3. nerves. In: Weiss SW, Goldblum JR, editors. Enzinger and
4. Weiss’s soft tissue tumors. 4th edition. St. Louis, Missouri:
5. Mosby; 2001. p.1111-1207. 3. Canda MŞ. Periferik sinir kılıfı tümörleri. Tr Ekopatol Derg
6. 2004; 10: 65-74. 4. Weiss SW, Goldblum JR. Malignant tumors of the
7. peripheral nerves. In: Weiss SW, Goldblum JR, editors.
8. Enzinger and Weiss’s soft tissue tumors. 4th edition. St.

9. Louis, Missouri: Mosby; 2001. p.1209-63. 5. Yamamoto T, Minami R, Ohbayashi C. Subcutaneous
10. malignant epithelioid schwannoma with cartilaginous
11. differentiation. J Cutan Pathol 2001; 28: 486-91. 6. Chang SM, Ho WL. Malignant peripheral nerve sheath
12. tumor: a study of 21 cases. Zhonghua Yi Xue Za Zhi
13. (Taipei) 1994; 54: 122-30. 7. Li Y, Yang H, Li G. Epithelioid variant of malignant peripheral nerve sheath tumor. Zhonghua Bing Li Xue Za
14. Zhi 1996; 25: 355-57. 8. Yılmaz F, Uzunlar AK, Bükte Y, Özekinci S, et al. Primary
15. malignant schwannoma of the small bowel. Turk J Med Sci
16. 2001; 31: 459-61. 9. Grayson W, Hale MJ. Epithelioid psammomatous melanotic
17. schwannoma with osseous metaplasia. Arch Pathol Lab
18. Med 1998; 122: 285-87. 10. Kasantikul V, Brown WJ, Netsky MG. Mesenchymal
19. differentiation in trigeminal neurilemmoma. Cancer 1982; 50: 1568-71. 11. Fanburg-Smith JC, Majidi M, Miettinen M. Keratin
20. expression in schwannoma: a study of 115 retroperitoneal
21. and 22 peripheral schwannomas. Mod Pathol 2006; 19: 115-21. 12. Gray MH, Rosenberg AE, Dickersin GR, Bhan AK. Glial
22. fibrillary acidic protein and keratin expression by benign
23. and malignant nevre sheath tumors. Hum Pathol 1989; 20: 1089-96. 13. Miettinen M. Melanotic schwannoma coexpression of
24. vimentin and glial fibrillary acidic protein. Ultrastruct Pathol
25. 1987; 11: 39-46. 14. Memoli VA, Brown EF, Gould VE. Glial fibrillary acidic
26. protein (GFAP) immunoreactivity in peripheral nevre sheath
27. tumors. Ultrastruct Pathol 1984; 7: 269-75. 15. Kawahara E, Oda Y, Ooi A, Katsuda S, et al. Expression of
28. glial fibrillary acidic protein (GFAP) in peripheral nevre
29. sheath tumors. A comparative study of immunoreactivity of
30. GFAP, vimentin, S-100 protein, and neurofilament in 38
31. schwannomas and 18 neurofibromas. Am J Surg Pathol
32. 1988; 12: 115-20. 16. Zhang HY, Yang GH, Chen HJ, Wei B, et al. Clinico- pathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma. Chin Med J
33. (Engl) 2005; 118: 1451-61. 17. Yasuda T, Sobue G, Ito T, Doyu M, et al. Human peripheral
34. nevre sheath neoplasm: expression of Schwann cell-related
35. markers and their relation to malignant transformation. Muscle
36. Nerve 1991; 14: 812-19. 18. Utermark T, Schubert JAS, Hanemann OC. Rearran
37. gements of the intermediate filament GFAP in primary
38. human schwannoma cells. Neurobiol Dis 2005; 19:1-9. 19. Gould VE, Moll R, Moll I, Lee I, et al. The intermediate
39. filament complement of the spectrum of nevre sheath
40. neoplasms. Lab Invest 1986; 55: 463-74. 20. Canda MŞ, Kırımca F, Gökden N, Pabuççuoğlu HU. Spinal
41. Schwannomanın patolojisi (7 olgu). Tr Ekopatol Derg 1997; 3: 35-36. 21. Daimaru Y, Hashimoto H, Enjoji M. Malignant peripheral
42. nevre-sheath tumors (malignant schwannomas) An
43. immunohistochemical study of 29 cases. Am J Surg Pathol
44. 1985; 9: 434-44. 22. Özel E, Peşterelli HE, Şimşek T, Karaveli FŞ, et al.
45. Malignant peripheral nerve sheath tumor of the vulva: A
46. case report. Turkish Journal of Cancer 2006; 36: 31-34.