Oligodendroglial tumors

Yıl 2004, Cilt: 10 Sayı: 1-2, 57 - 62, 01.05.2004

A. M. Sav

Öz

Oligodendroglioma is a type of infiltrating glioma composed of oligodendrocytes. This spectacular tumor consists %1-4 of all primary intracranial tumors as well as only 4-8% of all glial tumors. These tumors usually present in adulthood, but sometimes only after a long history of epilepsy. Some neoplasms with bland cytologic features grow extremely slowly, but anaplastic oligodendrogliomas behave aggresively. A variety of classifications are used for classifying the oligodendrogliomas. The is no consensus about the definition of pathologic parameters associated with survival rates. Also, to our knowledge no well defined prognosticators are in use for the oligodendrogliomas with a potential for recurrence and progression. Studies of the genetic abnormalities of oligodendrogliomas indicate that they are distinct from those of diffuse astrocytic neoplasms

Anahtar Kelimeler

Oligodendroglioma, anaplastic oligodendroglioma, pathology, immunohistochemistry, neuroradiology, classification, differential diagnosis, spread, treatment, prognosis

Oligodendroglial tümörler

Öz

Oligodendrogliomalar oligodendrositlerden oluşan infiltratif tümörlerdir. Bu tümörler primer intrakranyal tümörlerin % 1-4’ünü, tüm glial tümörlerin de % 4-8’lik bir grubunu oluştururlar. Genellikle erişkinlerin tümörü olan bu tümör grubundaki hastaların bir kısmında uzun yıllardan beri süregelen epilepsi öyküsü bulunur. Mikroskopik olarak sakin görünümlü hücrelerden oluşanları çok yavaş büyürken¸ anaplastik oligodendrogliomalar saldırgan bir klinik gidiş gösterirler. Oligodendrogliomaları sınıflayan farklı sınıflamalar bulunmaktadır. Sağkalım oranları ile ilişkilendirilebilecek patolojik değişkenler konusunda henüz bir uzlaşma yoktur. Bugünkü bilgilerimiz çerçevesi içinde, oligodendrogliomalarda nüks ve progresyon becerisini ön görecek belirteçler bulunmamaktadır. Genetik çalışmalarda saptanan bulgular, oligodendrogliomaların astrosit kökenli diffüz tümörlerden farklı olduğunu göstermektedir

Anahtar Kelimeler

Oligodendroglioma, anaplastik oligodendroglioma, patoloji, immünohistokimya, nöroradyoloji, sınıflamalar, ayırıcı tanı, yayılım, tedavi, prognoz

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