Effect of Balneotherapy on Serum Prolidase Enzyme Activity in Patients with Fibromyalgia: A Prospective Cross-Sectional Study

Öz

Objectives: The aim of this study was to compare the serum prolidase enzyme levels between patients with fibromyalgia syndrome (FMS) and healthy control subjects, and to investigate the possible effect of balneotherapy (BT) on prolidase enzyme levels in FMS patients. Materials and Methods: Included in the study were 45 patients who had been diagnosed with FMS according to American College of Rheumatology (ACR) criteria (2010), and 40 healthy volunteers. The socio-demographic data of the partipances in each group was recorded, and the Visual Analog Scale (VAS) and Fibromyalgia Impact Questionnaire (FIQ) was applied to patients with FMS. The FMS group took part in 20-minute BT sessions once a day for 21 days. To measure prolidase enzyme activity, venous blood samples were taken twice from the FMS group – before and after BT – and once from the control group. Results: The FMS group and the control group were similar in terms of age and body mass index (BMI). A comparison of the serum prolidase values of the two groups revealed a statistically significant difference (p <0.05). The serum prolidase values of the FMS group before and after BT were compared, and the difference was found to be statistically significant (p <0.05). Conclusion: The serum prolidase enzyme activity was found to be higher in patients with FM than in healthy subjects. However, serum prolidase enzyme activity decreased in patients with FMS after BT. These results can be of guidance for further clinical studies of the etiopathogenesis and treatment of FMS.

Anahtar Kelimeler

• Prolidase
• balneotherapy
• fibromyalgia

Balneoterapinin Fibromiyaljili Hastalarda Serum Prolidaz Enzim Aktivitesine Etkisi: Prospektif Kesitsel Çalışma

Öz

Amaç: Bu çalışmanın amacı fibromiyalji sendromlu (FMS) hastalar ile sağlıklı kontrol arasında serum prolidaz enzim düzeyini karşılaştırmak ve balneoterapinin (BT) FMS hastalarında prolidaz enzim düzeyi üzerine olası etkisini araştırmaktır. Gereç ve Yöntem: Çalışmaya American College of Rheumatology (ACR) kriterlerine (2010) göre FMS tanısı almış 45 hasta ve 40 sağlıklı gönüllü dahil edildi. Her iki gruptaki katılımcıların sosyo-demografik verileri kaydedildi ve FMS'li hastalara Görsel Analog Skala (VAS) ve Fibromiyalji Etki Anketi (FIQ) uygulandı. FMS’li hasta grubu 21 gün boyunca günde bir kez olmak üzere 20 dakikalık BT seanslarına katıldı. Prolidaz enzim aktivitesini ölçmek için venöz kan örnekleri kontrol grubundan 1 kez, FMS grubundan BT'den önce ve sonra olmak üzere iki kez alındı. Bulgular: FMS grubu ve kontrol grubu yaş ve vücut kitle indeksi (VKİ) açısından benzerdi. Gruplar serum prolidaz düzeyleri açısında karşılaştırıldığında gruplar arasında istatistiksel olarak anlamlı bir fark vardı (p <0.05). FMS grubunun serum prolidaz değerleri BT öncesi ve sonrası karşılaştırıldığında aralarındaki fark istatistiksel olarak anlamlı bulundu (p <0.05). Sonuç: Serum prolidaz enzim aktivitesi FMS hastalarında sağlıklı kontrollere göre daha yüksek bulundu. Bununla birlikte FMS’li hastalarda BT sonrası serum prolidaz enzim aktivitesi azaldı. Bu sonuçlar, FMS etiyopatogenezi ve tedavisi ile ilgili yapılacak olan klinik çalışmalar için yol gösterici olabilir.

Anahtar Kelimeler

• Prolidaz
• balneoterapi
• fibromiyalgi

Kaynakça

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