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İnsan Ve Hayvan Sağlığı Üzerine Dioksinlerin Etkileri

Yıl 2000, Cilt: 57 Sayı: 2, 99 - 108, 01.08.2000

Hidayet Yavuz Mehmet Özdemir

Öz

Poliklorlu dibenzo – p – dioksinler PCDD , poliklorlu dibenzo furanlar PCDF ve poliklorlu bifeniller PCB yapısal, kimyasal ve biyolojik özelliklerinin birbirleriyle benzer olması nedeniyle sıklıkla “ dioksinler „ olarak adlandırılırlar 1,2 . Bu bileşikler plonar konfigürasyonlu trisiklik halojenli aromatik hidrokarbonlardır. PCDD ve PCDF‘ler analitik standart ve araştırma materyalleri olarak kullanımı hariç, hiçbir zaman ticari amaçla üretilmemişlerdir 2 ; bunlar bazı klorlu kimyasal bileşiklerin imali sırasında yan ürün ve organik materyallerin yakılması sonucunda istenmeyen kirleticiler olarak ortaya çıkmaktadırlar 3 .

Kaynakça

  • Feil VJ, Ellis RL. The USDA perspective on dioxin concentrations in dairy and beef. J Anim Sci 1998; 76: 159.
  • Fries GF. A review of the significance of animal food products as potential pathways of human exposures to dioxins. J Anim Sci 1995; 73: 1639-1650.
  • Rowlands JC, Gustafsson JA. Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol 1997; 27: 134.
  • Longnecker MP, Rogan WJ, Lucier G. The human health effects of DDT (Dichlorodiphenyltrichloroethane) and PCBs (polychlorinated biphenyls) and an overview of organochlorines in public health. Annu Rev Public Health 1997; : 211-244.
  • Safe SH. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses and implications for risk assessment. Crit Rev Toxicol 1994; 24: 87-149.
  • Roeder RA, Garber MJ, Schelling GT. Assesment of dioxins in foods from animal origins. J Anim Sci 1998; 76: 151.
  • De Waal EJ, Schuurman HJ, Van Loveren H, Vos JG. Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, bis (tri-n-butyltin) oxide and cyclosporine on thymus histophysiology. Crit Rev Toxicol 1997; 27: 381-430.
  • Safe S. Limitations of the toxic equivalency factor approach for risk assessment of TCDD and Related compounds. Teratog Carcinog Mutagen 1997/98; 17: 285-304.
  • Saracci R, Kogevinas M, Bertazz PA, et al. Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols. Lancet 1991; 338: 1027-1032.
  • Zeyneloğlu HB, Arici A, Olive DL. Environmental toxins and endometriosis. Obstet Gynecol Clin North Am 1997; : 307-329.
  • Courtney DK, Gaylor DW, Hogon MD, Falk HL, Bates RR, Mitchell I. Teratogenic evaluation of 2,4,5-T. Science ; 1968: 864-866.
  • Sparschu GL, Donn FL, Rowe VK. Study of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Food Cosmet Toxicol 1971; 9: 405-412.
  • Watanabe S, Kitamura K, Nagahashi M. Effects of dioxins on human health: a review. J Epidemiol 1999; : 1-13.
  • Neumann HG. Toxic equivalance factors, problems and limitations. Food Chemical Toxicol 1996; 34: 1045
  • Grassman JA, Masten SA, Walker NJ, Lucier GW. Animal models of human response to perspect. Environ Health Perspect 1998; 2: 761-775.
  • Mukerjee D. Health impact of polychlorinated dibenzo-p-dioxins: a critical review. J Air Waste Manag Assoc ; 48: 157-165.
  • Ramons L, Enjamat E, Hernandez LM, Alonro L, Rivera J, Gonzalez Mj. Levels of PCDDs and PCDFs in farm cows milk located near potential contaminant sources in Asturias (Spain). Comprasion with levels found in central rural farms and commerical pasteurized cows milks. Chemosphere 1997; 35: 2167-2179.
  • Dyke PH, Foan C, Wenborn M, Coleman PJ. A review of dioxin releases to land and water in the UK. Sci Total Environ 1997; 207: 119-131.
  • Fielder H. Sources of PCDD/PCDF and impact on the environment. Chemosphere 1996; 32: 55-64.
  • Fries GF, Paustenbach DJ. Evaluation of potential transmission of 2,3,7,8- tetrachlorodibenzo-p-dioxin contaminated incinerator emissions to humans via foods. J Toxicol Environ Health 1990; 29: 1-43.
  • Stevens JB, Gerbec EN. Dioxin in agricultural food chain. Risk Anal 1988; 8: 329-335.
  • Schecter A, Li L. Dioxins, dibenzofurans, dioxin-like PCBs and DDE in US fast food, 1995. Chemosphere 1997; : 1449-1457.
  • Schlatter C. Chlorinated dibenzo-p-dioxins and –furans: problems in analysis of biomarkers. Clin Chem 1994; : 1405-1408.
  • Eduljee GH, Gair AJ. Validation of a methodology for modelling PCDD and PCDF intake via the food chain. Sci Total Environ 1996; 187: 211-229.
  • Svensson BG, Nilsson A, Hansson M, Rappe C, Akesson B, Skerfuing S. Exposure to dioxins and dibenzofurans through the consumption of fish. N Engl J Med 1991; 324: 8-12.
  • Schaler F, Schmid P, Schlatter C. The transfer of polychlorinated dibenzo-p-dioxins from soil into eggs of foraging chicken. Chemosphere 1997; 34: 711-718.
  • Gasiewicz TA. Dioxins and the Ah reseptor: Probes to uncover processes in neuroendocrine development. Neurotoxicology 1997; 18: 393-413.
  • Poland A. Reflections on risk assesment of receptor acting xenobiotics. Regul Toxicol Pharmacol 1997; 26: 43.
  • Pratt WB, Toft DO. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr Rev 1997; 18: 306-360.
  • Safe S, Krishnan V. Chlorinated Hydrocarbons: estrogens and antiestrogens. Toxicol Lett 1995; 82-83: 731-736.
  • Tilson HA, Kodavanti PR. The neurotoxicity of polychlorinated biphenyls. Neurotoxicology 1998; 19: 517-525.
  • Whitlock JMJ. Mechanistic aspects of dioxin action. Chem Res Toxicol 1993; 6: 754-763.
  • Okey AB, Riddick DS, Harper PA. The Ah receptor: mediator of the toxicity 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Toxicology Letters 1994; 70: 1-22.
  • Fernandez-Salguero P, Pineau T, Hilbert DM, et al. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah reseptor. Science 1995; 268: 722-726.
  • Eadon G, Kominsky L, Silkworth J, et al. Calculation of 2,3,7,8-TCDD equivalent concentrations of complex environmental contaminant mixtures. Environ Health Perspect 1986; 70: 221-227.
  • Harris M, Zacharewski, T Safe S. Comparative potencies of Araclors 1232, 1242, 1248, 1254 and 1260 in male
  • Wistar rats assessment of toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs). Fund Appl Toxicol 1993; 20: 456-463.
  • Safe SH. Development validation and problems with the toxic equivalency factor approach for risk assessment of dioxins and related compounds. J Anim Sci 1998; 76: 134-141.
  • Nishimoto M, Yanagida GK, Stein JE, Baird WM, Varanasi U. The metabolism of benzo(a)pyrene by English Sole (Parophrys vetulus): comparison between isolated hepatocytes in vitro and liver in vivo. Xenobiotica 1992; 22: 961.
  • USEPA: Scientific Advisory Board: Re-evaluating dioxin. Scienci Advisory Board’s review of EPA’s reassess- ment of dioxin and dioxin-like compounds. Washington, DC; US Environment Printing Office 1995; Report No: EPA- SAB-EC-95-021.
  • Geyer HJ, Schramm KW, Scheunert I, et al. Conciderations on genetic and environmental factors that contribute to resistance or sensitivity of mammals including humans to toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds part 1. Genetic factors affecting the toxicity of TCDD. Ecotoxicol Environ Saf 1997; : 213-230.
  • Neubert D. Reflections on the assesment of the toxicity of “dioxins” for humans, using data from experimental and epidemiological studies. Teratog Carcinog Mutagen 1997/1998; 17: 157- 215.
  • Birnbaum LS. Developmental effects of dioxins. Environ Health Perspect 1985; 7: 89-94.
  • Janz DM, Bellward GD. In Ovo 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in three avian species. 1. Effects on thyroid hormones and growth during the perinatal period. Toxicol Appl Pharmacol 1996; 139: 281-291.
  • Albright DF, Goldstein RA. Airbone pollutants and the immune system. Otolaryngol Head Neck Surg 1996; 114: 238.
  • Vos JG, De Heer C, Van Loveren H. Immunotoxic effects of TCDD and toxic equivalency factors. Teratogen Carcinogen Mutagen 1997; 17: 275-284.
  • Fingerhut MA, Halperin WE, Marlow DA, et al. Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodiben- zo-p-dioxin. N Engl J Med 1991; 324: 212-218.
  • Zahm SH, Fraumeni JF. The epidemiology of soft tissue sarcoma. Seminers in Oncology 1997; 24: 504-514.
  • WHO: Regional Office for Europe. Consultation on tolerable daily intake from food of PCDDs and PCDFs. Copenhagen: WHO, 1991; 5pp.
  • Chen YC, Guo YL, Hsu CC, Rogan,WJ. Cognitive development of Yu-Cheng ( oil disease ) children prenatally exposed to head-degraded PCBs. JAMA 1992; 268: 3213-3218.

Effects Of Dioxins On Human And Animal Health

Yıl 2000, Cilt: 57 Sayı: 2, 99 - 108, 01.08.2000

Hidayet Yavuz Mehmet Özdemir

Öz

Kaynakça

  • Feil VJ, Ellis RL. The USDA perspective on dioxin concentrations in dairy and beef. J Anim Sci 1998; 76: 159.
  • Fries GF. A review of the significance of animal food products as potential pathways of human exposures to dioxins. J Anim Sci 1995; 73: 1639-1650.
  • Rowlands JC, Gustafsson JA. Aryl hydrocarbon receptor-mediated signal transduction. Crit Rev Toxicol 1997; 27: 134.
  • Longnecker MP, Rogan WJ, Lucier G. The human health effects of DDT (Dichlorodiphenyltrichloroethane) and PCBs (polychlorinated biphenyls) and an overview of organochlorines in public health. Annu Rev Public Health 1997; : 211-244.
  • Safe SH. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses and implications for risk assessment. Crit Rev Toxicol 1994; 24: 87-149.
  • Roeder RA, Garber MJ, Schelling GT. Assesment of dioxins in foods from animal origins. J Anim Sci 1998; 76: 151.
  • De Waal EJ, Schuurman HJ, Van Loveren H, Vos JG. Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, bis (tri-n-butyltin) oxide and cyclosporine on thymus histophysiology. Crit Rev Toxicol 1997; 27: 381-430.
  • Safe S. Limitations of the toxic equivalency factor approach for risk assessment of TCDD and Related compounds. Teratog Carcinog Mutagen 1997/98; 17: 285-304.
  • Saracci R, Kogevinas M, Bertazz PA, et al. Cancer mortality in workers exposed to chlorophenoxy herbicides and chlorophenols. Lancet 1991; 338: 1027-1032.
  • Zeyneloğlu HB, Arici A, Olive DL. Environmental toxins and endometriosis. Obstet Gynecol Clin North Am 1997; : 307-329.
  • Courtney DK, Gaylor DW, Hogon MD, Falk HL, Bates RR, Mitchell I. Teratogenic evaluation of 2,4,5-T. Science ; 1968: 864-866.
  • Sparschu GL, Donn FL, Rowe VK. Study of the teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Food Cosmet Toxicol 1971; 9: 405-412.
  • Watanabe S, Kitamura K, Nagahashi M. Effects of dioxins on human health: a review. J Epidemiol 1999; : 1-13.
  • Neumann HG. Toxic equivalance factors, problems and limitations. Food Chemical Toxicol 1996; 34: 1045
  • Grassman JA, Masten SA, Walker NJ, Lucier GW. Animal models of human response to perspect. Environ Health Perspect 1998; 2: 761-775.
  • Mukerjee D. Health impact of polychlorinated dibenzo-p-dioxins: a critical review. J Air Waste Manag Assoc ; 48: 157-165.
  • Ramons L, Enjamat E, Hernandez LM, Alonro L, Rivera J, Gonzalez Mj. Levels of PCDDs and PCDFs in farm cows milk located near potential contaminant sources in Asturias (Spain). Comprasion with levels found in central rural farms and commerical pasteurized cows milks. Chemosphere 1997; 35: 2167-2179.
  • Dyke PH, Foan C, Wenborn M, Coleman PJ. A review of dioxin releases to land and water in the UK. Sci Total Environ 1997; 207: 119-131.
  • Fielder H. Sources of PCDD/PCDF and impact on the environment. Chemosphere 1996; 32: 55-64.
  • Fries GF, Paustenbach DJ. Evaluation of potential transmission of 2,3,7,8- tetrachlorodibenzo-p-dioxin contaminated incinerator emissions to humans via foods. J Toxicol Environ Health 1990; 29: 1-43.
  • Stevens JB, Gerbec EN. Dioxin in agricultural food chain. Risk Anal 1988; 8: 329-335.
  • Schecter A, Li L. Dioxins, dibenzofurans, dioxin-like PCBs and DDE in US fast food, 1995. Chemosphere 1997; : 1449-1457.
  • Schlatter C. Chlorinated dibenzo-p-dioxins and –furans: problems in analysis of biomarkers. Clin Chem 1994; : 1405-1408.
  • Eduljee GH, Gair AJ. Validation of a methodology for modelling PCDD and PCDF intake via the food chain. Sci Total Environ 1996; 187: 211-229.
  • Svensson BG, Nilsson A, Hansson M, Rappe C, Akesson B, Skerfuing S. Exposure to dioxins and dibenzofurans through the consumption of fish. N Engl J Med 1991; 324: 8-12.
  • Schaler F, Schmid P, Schlatter C. The transfer of polychlorinated dibenzo-p-dioxins from soil into eggs of foraging chicken. Chemosphere 1997; 34: 711-718.
  • Gasiewicz TA. Dioxins and the Ah reseptor: Probes to uncover processes in neuroendocrine development. Neurotoxicology 1997; 18: 393-413.
  • Poland A. Reflections on risk assesment of receptor acting xenobiotics. Regul Toxicol Pharmacol 1997; 26: 43.
  • Pratt WB, Toft DO. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr Rev 1997; 18: 306-360.
  • Safe S, Krishnan V. Chlorinated Hydrocarbons: estrogens and antiestrogens. Toxicol Lett 1995; 82-83: 731-736.
  • Tilson HA, Kodavanti PR. The neurotoxicity of polychlorinated biphenyls. Neurotoxicology 1998; 19: 517-525.
  • Whitlock JMJ. Mechanistic aspects of dioxin action. Chem Res Toxicol 1993; 6: 754-763.
  • Okey AB, Riddick DS, Harper PA. The Ah receptor: mediator of the toxicity 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds. Toxicology Letters 1994; 70: 1-22.
  • Fernandez-Salguero P, Pineau T, Hilbert DM, et al. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah reseptor. Science 1995; 268: 722-726.
  • Eadon G, Kominsky L, Silkworth J, et al. Calculation of 2,3,7,8-TCDD equivalent concentrations of complex environmental contaminant mixtures. Environ Health Perspect 1986; 70: 221-227.
  • Harris M, Zacharewski, T Safe S. Comparative potencies of Araclors 1232, 1242, 1248, 1254 and 1260 in male
  • Wistar rats assessment of toxic equivalency factor (TEF) approach for polychlorinated biphenyls (PCBs). Fund Appl Toxicol 1993; 20: 456-463.
  • Safe SH. Development validation and problems with the toxic equivalency factor approach for risk assessment of dioxins and related compounds. J Anim Sci 1998; 76: 134-141.
  • Nishimoto M, Yanagida GK, Stein JE, Baird WM, Varanasi U. The metabolism of benzo(a)pyrene by English Sole (Parophrys vetulus): comparison between isolated hepatocytes in vitro and liver in vivo. Xenobiotica 1992; 22: 961.
  • USEPA: Scientific Advisory Board: Re-evaluating dioxin. Scienci Advisory Board’s review of EPA’s reassess- ment of dioxin and dioxin-like compounds. Washington, DC; US Environment Printing Office 1995; Report No: EPA- SAB-EC-95-021.
  • Geyer HJ, Schramm KW, Scheunert I, et al. Conciderations on genetic and environmental factors that contribute to resistance or sensitivity of mammals including humans to toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds part 1. Genetic factors affecting the toxicity of TCDD. Ecotoxicol Environ Saf 1997; : 213-230.
  • Neubert D. Reflections on the assesment of the toxicity of “dioxins” for humans, using data from experimental and epidemiological studies. Teratog Carcinog Mutagen 1997/1998; 17: 157- 215.
  • Birnbaum LS. Developmental effects of dioxins. Environ Health Perspect 1985; 7: 89-94.
  • Janz DM, Bellward GD. In Ovo 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in three avian species. 1. Effects on thyroid hormones and growth during the perinatal period. Toxicol Appl Pharmacol 1996; 139: 281-291.
  • Albright DF, Goldstein RA. Airbone pollutants and the immune system. Otolaryngol Head Neck Surg 1996; 114: 238.
  • Vos JG, De Heer C, Van Loveren H. Immunotoxic effects of TCDD and toxic equivalency factors. Teratogen Carcinogen Mutagen 1997; 17: 275-284.
  • Fingerhut MA, Halperin WE, Marlow DA, et al. Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodiben- zo-p-dioxin. N Engl J Med 1991; 324: 212-218.
  • Zahm SH, Fraumeni JF. The epidemiology of soft tissue sarcoma. Seminers in Oncology 1997; 24: 504-514.
  • WHO: Regional Office for Europe. Consultation on tolerable daily intake from food of PCDDs and PCDFs. Copenhagen: WHO, 1991; 5pp.
  • Chen YC, Guo YL, Hsu CC, Rogan,WJ. Cognitive development of Yu-Cheng ( oil disease ) children prenatally exposed to head-degraded PCBs. JAMA 1992; 268: 3213-3218.
Toplam 50 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derleme
Yazarlar

Hidayet Yavuz Bu kişi benim

Mehmet Özdemir Bu kişi benim

Yayımlanma Tarihi 1 Ağustos 2000
Yayımlandığı Sayı Yıl 2000 Cilt: 57 Sayı: 2

Kaynak Göster

APA Yavuz, H., & Özdemir, M. (2000). İnsan Ve Hayvan Sağlığı Üzerine Dioksinlerin Etkileri. Türk Hijyen Ve Deneysel Biyoloji Dergisi, 57(2), 99-108.
AMA Yavuz H, Özdemir M. İnsan Ve Hayvan Sağlığı Üzerine Dioksinlerin Etkileri. Turk Hij Den Biyol Derg. Ağustos 2000;57(2):99-108.
Chicago Yavuz, Hidayet, ve Mehmet Özdemir. “İnsan Ve Hayvan Sağlığı Üzerine Dioksinlerin Etkileri”. Türk Hijyen Ve Deneysel Biyoloji Dergisi 57, sy. 2 (Ağustos 2000): 99-108.
EndNote Yavuz H, Özdemir M (01 Ağustos 2000) İnsan Ve Hayvan Sağlığı Üzerine Dioksinlerin Etkileri. Türk Hijyen ve Deneysel Biyoloji Dergisi 57 2 99–108.
IEEE H. Yavuz ve M. Özdemir, “İnsan Ve Hayvan Sağlığı Üzerine Dioksinlerin Etkileri”, Turk Hij Den Biyol Derg, c. 57, sy. 2, ss. 99–108, 2000.
ISNAD Yavuz, Hidayet - Özdemir, Mehmet. “İnsan Ve Hayvan Sağlığı Üzerine Dioksinlerin Etkileri”. Türk Hijyen ve Deneysel Biyoloji Dergisi 57/2 (Ağustos 2000), 99-108.
JAMA Yavuz H, Özdemir M. İnsan Ve Hayvan Sağlığı Üzerine Dioksinlerin Etkileri. Turk Hij Den Biyol Derg. 2000;57:99–108.
MLA Yavuz, Hidayet ve Mehmet Özdemir. “İnsan Ve Hayvan Sağlığı Üzerine Dioksinlerin Etkileri”. Türk Hijyen Ve Deneysel Biyoloji Dergisi, c. 57, sy. 2, 2000, ss. 99-108.
Vancouver Yavuz H, Özdemir M. İnsan Ve Hayvan Sağlığı Üzerine Dioksinlerin Etkileri. Turk Hij Den Biyol Derg. 2000;57(2):99-108.