İnokulasyonun multifokal tekniği kullanılarak walker 256 tümörüne histopatolojik olarak yaklaşımlar

Yıl 2013, Cilt: 70 Sayı: 1, 43 - 49, 01.03.2013

Maria Rita Garbi Novaes Roberto Cañete Villafranca Luiz Carlos Garcez Novaes

Öz

Kanser, dünyada büyük ekonomik ve sosyal kayıplara neden olan ciddi felaketlerden birisi olarak tanımlanmaktadır. Sağlığı bozan bu vakaların artışı göz önüne alındığında, mevcut değişen etkinlik ile sık sık yan etki gösteren kemoterapi protokolleri, dünyada kanser terapisi ve kanserden koruyucu yeni stratejilerin geliştirilmesini gerekliliği ortaya çıkmaktadır. Walker 256 tümörünün kanser çalışmalarında kullanılan en yaygın deneysel tümör olmasına rağmen bu konuda sağlık personelinin çok az bilgiye sahip olduğu iyi bilinen bir gerçektir. Bu çalışmanın amacı; deneysel tümörleri gözden geçirmek ve aynı zamanda sağlık çalışanlarının bilgi düzeylerini derinleştirerek artırmaktır

Anahtar Kelimeler

Kanser, walker tümörü, deney

Histopathological aspects of walker 256 tumor using the multifocal technique of inoculation

Öz

Cancer has been considered one of the most serious calamities all over the world, producing tremendous economic and social losses. Considering the increasing incidence of these health disturbances, the variable efficacy and frequent adverse events commonly notified with the existing chemotherapy protocols and the new events currently in progress in the world it´s urgent to develop new strategies to prevent and treat cancer. It is well known that walker 256 tumor is the most common experimental tumor model to study cancer but public health personnel still have little information about it. The aim of this study is not only to review the important aspects of this experimental tumor but also to increase the knowledge and comprehension about it among health professionals

Anahtar Kelimeler

Cancer, walker tumor, experiment

Kaynakça

• Gomes-Marcondes MCC, Honma HN, Cury L. Effect of walker 256 tumor growth on intestinal absorption of leucine, methionine and glucose in newly weaned and mature rats. Braz J Med Biol Res. 1998; 31: 1345-8.
• Miao XR, Gao XF, Wu JX, Lu ZJ, Hunang ZX, Li XQ, et al. Bilateral down regulation of Nav 1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with walker 256 breast tumor cells. BMC Cancer, 2010; 10:216.
• Novaes MRCG, Lima LAM, Souza MV. Efeitos farmacológicos da suplementação dietética com L-arginina a 6% em tumores experimentais. Rev Metabol Nutr, 2003; 7(2):52-6.
• Lan LS, Ping YJ, Na WL, Miao J, Cheng QQ, Ni MZ, et al. Down-regulation of toll-like receptor 4 gene expression by short interfering RNA attenuates bone cancer pain in a rat model. Ann Mol Pain, 2010; 6: 2.
• Earle WR. A study of the walker rat mammary carcinoma 256, in vivo and in vitro. Am J Cancer Res, 1935; 24: 566-612.
• Fisher ER, Fisher, B. Electron microscopic, histologic and histochemical features of the walker carcinoma. Cancer Res, 1961; 21: 527-30.
• Guaitani A, Recchia M, Carli M, Rocchetti M, Bartosek I, Garattini S. Walker carcinoma 256: a model for studies on tumor anorexia and cachexia. Oncology, 1982; 39:173-8.
• Morano JA, Cordeiro N, Guimarães SB, Fechine- Jamacaru FV, Vasconcelos PR, Moraes Filho MO. Experimental model of ultrasound thermotherapy in rats inoculated with walker-236 tumor. Acta Cir Bras, 2012; 27(1):13-7.
• Camargo CA, da Silva ME, da Silva RA, Justo GZ, Gomes-Marcondes MC, Aoyama H. Inhibition of tumor growth by quercetin with increase of survival and prevention of cachexia in walker 256 tumor-bearing rats. Biochem Biophys Res Commun, 2011; 406(4): 638-42.
• Mattos MCFI, Montenegro MR, Silva CRV. Walker 256 carcinossarcoma: pathology, microscopic and ultrastructural features of the tumoral circulating cells. Ciên Cult, 1980; 32(7): 849-57.
• Rettori O, Vieira- Matos NA, Gontijo JA. Reduced renal sodium excretion in walker 256 tumor- bearing rats. APPTLA, 1996; 46: 111-8.
• Simpkins H, Lehman JM, Mazurkiewicz JE, Davis BH. A morphological and phenotypic analysis of walker 256 cells. Cancer Res, 1991; 51(4): 1334-8.
• Hester JE, Fee WE. Effect of arginine on growth of squamous cell carcinoma in the c3h/km mouse. Arch Otolaryngol Head Neck Surg, 1995; 121(2): 193-6.
• Idris AI, Libouban H, Nyangoga H, Landao-Bassonga E, Chappard D, Ralston SH. Pharmacologic inhibitors of ikappa B kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo. Mol Cancer Ther, 2009; 8(8): 2339-47.
• Badraoui R, Blouin S, Moreau MF, Gallois Y, Rebai T, Sahnoun Z, et al. Effect of alpha tocopherol acetate in walker 256/B cells-induced oxidative damage in a rat model of breast cancer skeletal metastases. Chem Biol Interact, 2009; 182(2-3): 98-105.
• Freire-Garabal M, Nuñez MJ, Pereiro D, Riveiro P, Losada C, Fernandez-Rial JC, et al. Effects of fluoxetine on the development of lung metastases induced by operative stress in rats. Life Sci, 1998; 62(2): 31-8.
• Morrison SD. Water Intake and exchange and hydration of rats during growth of walker 256 carcinoma. J Nat Canc Inst, 1971; 46(4): 825-9.
• Ye SL, Istafan NW, Driscoll DF, Bistrian BR. Tumor and host response to arginine and branched chain amino acid enriched total parenteral nutrition. Cancer, 1992; 69(1): 261-70.
• Camargo CA, Gomes-Marcondes MC, Wutzki NC, Aoyama H. Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor α levels in rats with walker 256 carcinosarcoma. Anticancer Res, 2012; 32(1): 129-33.