İmmün sistemi baskılanmış hastada Listeria monocytogenes’e baglı septisemi ve menenjitin tedavisnde seftriaksondan ampisilin'e erken geçiş

Yıl 2020, Cilt: 77 Sayı: 4, 493 - 496, 01.12.2020

Gülşen Hazırolan Gülçin Dizman

Öz

Listeria monocytogenes is an important pathogen that may cause infection in the elderly and in immunocompromised patients with predisposing conditions. It can be an important cause of lifethreatening bacteremia and meningoencephalitis in immunocompromised individuals. In this report, it was described a case of sepsis and menegititis caused by L. monocytogenes in a 39-year-old female with adenoid cystic carcinoma of the larynx. L. monocytogenes identification was performed at the species level using matrix-assisted laser desorption ionization-time of flight mass spectrometry MALDI-TOF MS, Bruker Daltonics, Germany . The patient was treated with an early switch therapy from ceftriaxone to ampicillin. This report indicates that early detection and treatment of Listeria sepsis and meningitis are important to obtain a better prognosis

Anahtar Kelimeler

Listeria monocytogenes, meningitis, septicemia, MALDI TOF MS

Early switch therapy from ceftriaxone to ampisilin in an immunosuppressed patient with Listeria monocytogenes septicemia and meningitis

Öz

Listeria monocytogenes, yaşlılarda ve predispozan koşulları olan bağışıklık sistemi baskılanmış hastalarda enfeksiyona neden olabilecek önemli bir patojendir. Bu bakteri, bağışıklık sistemi baskılanmış kişilerde hayatı tehdit eden bakteriyemi ve meningoensefalitin önemli bir nedeni olabilir. Bu raporda, larenks adenoid kistik karsinomu olan 39 yaşındaki bir kadın hastada L. monocytogenes’in etken olduğu sepsis ve menenjit olgusu tanımlandı. L. monocytogenes’in tür düzeyinde tanımlanması matrix-assisted laser desorption and ionization timeof-flight mass spectrometry MALDI-TOF MS, Bruker, Almanya ile yapıldı. Hasta tedavide seftriaksondan ampisiline erken geçiş ile tedavi edildi. Bu rapor, Listeria sepsis ve meninjitinin erken saptanmasının ve tedavisinin, daha iyi bir prognoz elde edilmesindeki önemini işaret etmektedir

Anahtar Kelimeler

Listeria monocytogenes, menenjit, sepsis, MALDI TOF MS

Kaynakça

• Orsi RH1, Wiedmann M. Characteristics and distribution of Listeria spp., includingListeria species newly described since 2009. Appl Microbiol Biotechnol, 2016; 100(12): 5273-87.
• Lorber B. Listeriosis. Clin Infect Dis, 1997; 24(1): 1–1.
• Wang HL, Ghanem KG, Wang P, Yang S, Li TS. Listeriosis at a tertiary care hospital in beijing, china: high prevalence of nonclustered healthcare-associated cases among adult patients. Clin Infect Dis, 2013; 56(5): 666-76.
• Douglas A. Drevets, Michael S. Bronze. Listeria monocytogenes: epidemiology, human disease, and mechanisms of brain invasion. FEMS Microbiol Immunol, 2008; 53(2): 151-65.
• Stavru F, Archambaud C, Cossart P. Cell biology and immunology of Listeria monocytogenes infections: novel insights. Immunol Rev, 2011; 240(1): 160-84.
• Jing-Jing Liang, Xiao-Yan He, Hong Ye. Rhombencephalitis monocytogenes with hydrocephalus and intracranial hemorrhage: A case report and review of the literatüre. World J Clin Cases, 2019; 4(7): 538–7. by Listeria
• Morvan A, Moubareck C, Leclercq A, Hervé- Bazin M, Bremont S, Lecuit M. Antimicrobial resistance of Listeria monocytogenes strains isolated from humans in France. Antimicrob Agents Chemother, 2010; 54(6): 2728-31.
• Heyderman RS. Early management of suspected bacterial meningitis and meningococcal septicaemia in immunocompetent adults- second edition. J Infect, 2005; 50(5): 373-74.
• Tunkel AR, Hartman BJ, Kaplan SL, Kaufman BA, Roos KL, Scheld WM, Whitley RJ. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis, 2004; 39(9): 1267- 84.