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Sedanter erkeklerde egzersize bağlı iskelet kası zorlanmasının enerji düzenleyici hormonlar olan irisin ve nesfatin-1 üzerine olan etkileri

Yıl 2020, Cilt: 77 Sayı: 2, 227 - 232, 01.06.2020

Öz

Amaç: Egzersiz, vücut enerji metabolik sistem aktivitesini, mekanik aktiviteyi veya hormonal etkileri artırarak düzenleyen önemli bir yöntemdir. Bu çalışmadaki amacımız aerobik egzersizin enerji tüketimini artıran irisin hormonu ve enerji alımını baskılayan nesfatin-1 hormonu üzerine etkilerini ve bunların kas hasarı artışını yansıtan kreatin kinase CK ile ilişkisini incelemektir.Yöntem: Toplam 30 sağlıklı, sedanter erkek katılımcıya anaerobik eşiklerinde 30 dakika aerobik koşu egzersizi uygulandı. Egzersiz öncesi ve sonrası kan örnekleri alındı. Serum irisin, nesfatin-1 ve CK analiz edildi. Bulgular: Tüm katılımcılarda egzersiz süresince serum irisin ve CK düzeyleri artış gösterdi %16.4 ve %25.7 sırası ile . Ortalama değerler istatistiksel olarak anlamlı artış göstermesine rağmen nesfatin-1 düzeyi tüm katılımcılarda artış göstermedi %12.1 . Irisin ve CK seviyelerindeki artışlar arasında pozitif yönde istatistiksel olarak anlamlı korelasyon sapyandı. Sonuç: Egzersize bağlı iskelet kası aktivitesi CK ve irisin seviyelerinde artışa neden olabilir. Nesfatin-1 egzersize bağlı hormon gibi görünmeyebilir ve artmış kas aktivitesi ile korelasyon göstermemektedir. Orta yoğunluktaki aerobik egzersiz metabolik hormonları değiştirerek vücut enerji düzenleyici sistemleri üzerinde faydalı etkiler sağlayabilir

Kaynakça

  • 1. Wang Z, Tsujimoto T,Wakaba K, Mizushima R, Kobayashi H, Tanaka K. Associations of various exercise types with health-related physical fitness: Focus on physical fitness age. J Phys Fitness Sports Med, 2020; 9 (2): 75-2.
  • 2. Nunan D, Mahtani KR, Roberts N, Heneghan C. Physical activity for the prevention and treatment of major chronic disease: an overview of systematic reviews. Syst Rev, 2013; 2: 56.
  • 3. Ozcelik O, Ozkan Y, Algul S, Çolak R. Beneficial effects of training at the anaerobic threshold in addition to pharmacotherapy on weight loss, body composition, and exercise performance in women with obesity. Patient Prefer Adherence, 2015; 9: 999-1004.
  • 4. Leal LG, Lopes MA, Batista ML JR. Physical exerciseınduced myokines and muscle-adipose tissue crosstalk: a review of current knowledge and the ımplications for health and metabolic diseases. Front Physiol, 2018; 9: 1307.
  • 5. Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 2012; 481: 463–68.
  • 6. Polyzos SA, Kountouras J, Shields K, Mantzoros CS. Irisin: a renaissance in metabolism? Metabolism, 2013; 62 (8): 1037-44.
  • 7. Perakakis N, Triantafyllou GA, Fernández-Real JM, Huh JY, Park KH, Seufert J, et al. Physiology and role of irisin in glucose homeostasis. Nat Rev Endocrinol, 2017; 13 (6): 324-37.
  • 8. Oh-I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, et al. Identification of nesfatin-1 as a satiety molecule in the hypothala¬mus. Nature, 2006; 443: 709-12.
  • 9. Stengel A, Tache Y. Nesfatin-1--role as possible new potent regulator of food intake. Regul Pept, 2010; 163 (1-3): 18-3.
  • 10. Algul S, Ozkan Y, Ozcelik O. Serum nesfatin-1 levels in patients with different glucose tolerance levels. Physiol Res, 2016; 65 (6): 979-85.
  • 11. Tekin T, Çiçek B, Konyalıgil N. Regulatory peptide nesfatin-1 and its relationship with metabolic syndrome. Eurasian J Med, 2019; 51 (3): 280-4.
  • 12. Yosten GL, Samson WK. Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system. Am J Physiol Regul Integr Comp Physiol, 2009; 297 (2): 330-6.
  • 13. Algul S, Ozcelik O. Evaluating the levels of nesfatin-1 and ghrelin hormones in patients with moderate an severe major depressive disorders. Psychiatry Investig, 2018; 15 (2): 214-8.
  • 14. Daskalopoulou SS, Cooke AB, Gomez YH, Mutter AF, Filippaios A, Mesfum ET, et al. Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. Eur J Endocrinol, 2014; 171 (3): 343-52.
  • 15. Algul S, Ozdenk C, Ozcelik O. Variations in leptin, nesfatin-1 and irisin levels induced by aerobic exercise in young trained and untrained male subjects. Biol Sport, 2017; 34 (4): 339-44.
  • 16. Nygaard H, Slettalokken G, Vegge G, Hollan I, Whist JE, Strand Tor, et al. Irisin in blood increases transiently after single sessions of intense endurance exercise and heavy strength training. Plos One, 2015; 10 (3): e0121367.
  • 17. Kurdiova T, Balaz M, Mayer A, Maderova D, Belan V, Wolfrum C, et al. Exercise- mimicking treatment fails to increase Fndc5 mRNA and irisin secretion in primary human myotubes. Peptides, 2014; 56: 1-7.
  • 18. Raschke S, Elsen M, Gassenhuber H, Sommerfeld M, Schwahn U, Brockmann B, et al. Evidence against a beneficial effect of irisin in humans. Plos One, 2013; 8 (9): e73680.
  • 19. Pekkala S, Wiklund PK, Hulmi JJ, Ahtiainen JP, Horttanainen M, Pöllänen E, et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? J Physiol, 2013; 591 (21): 5393-400.
  • 20. Arıkan S. Effects of acute and chronic exercises on plasma nesfatin-1 levels in young adults. Cyprus J Med Sci, 2020; 5(1): 77-80.
  • 21. Yazici AG. Relationship and interaction between anaerobic sports branches and serum nesfatin-1. Turk J Phys Med Rehab, 2015; 61: 234-40.
  • 22. Ghanbari-Niaki A, Kraemer RR, Soltani R. Plasma nesfatin-1 and glucoregulatory hormone responses to two different anaerobic exercise sessions. Eur J Appl Physiol, 2010;110 (4): 863-8.
  • 23. Algul S, Ozçelik O. Determination of the effects of acute aerobic exercise on nesfatin-1 levels. F.U Sag Bil Tip Derg, 2016; 30 (5): 8-16.
  • 24. Koh TJ. Physiology and mechanisms of skeletal muscle damage. In: P.M. Tiidus (ed.) Skeletal muscle damage and repair. Human Kinetics Champaign IL, 2008; 3-12.
  • 25. Brancaccio P, Maffulli N, Limongelli FM. Creatine kinase monitoring in sport medicine. Br Med Bull, 2007; 81 (82): 209-30.
  • 26. Baird MF, Graham SM, Baker JS, Bickerstaff GF. Creatine-kinase- and exercise-relatedmuscle damage ımplications for muscle performance and recovery. J Nutr Metab, 2012; ID 960363: 13.
  • 27. Kaya H, Özçelik O. Comparison of effectiveness of body mass index and bioelectric impedance analysis methods on body composition in subjects with different ages and sex. F.U Sag Bil Tip Derg, 2009; 23 (1): 1-5.
  • 28. American College of Sports Medicine (ACSM). Guidelines for Exercise Testing and Prescription (9th ed.). Baltimore, MD: Lippincott, Williams and Wilkins, 2014.
  • 29. Huh JY, Siopi A, Mougios V, Park KH, Mantzoros CS. Irisin in response to exercise in humans with and without metabolic syndrome. J Clin Endocrinol Metab, 2015; 100 (3): 453-7.
  • 30. Kraemer RR, Shockett P, Webb ND, Shah U, Castracane VD. A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women. Horm Metab Res, 2014; 46 (2): 150-4.
  • 31. Ozcelik O, Algul S, Yilmaz B. Nesfatin-1 and irisin levels in response to the soccer matches performed in morning, afternoon and at night in young trained male subjects. Cell Mol Biol (Noisy-le-Grand, France), 2018; 64 (10): 130-3.
  • 32. Ozbay S, Ulupınar S, Şebin E, Altınkaynak K. Acute and chronic effects of aerobic exercise on serum ırisin, adropin, and cholesterol levels in the winter season: ındoor training versus outdoor training. Chin J Physiol, 2020; 63 (1): 21-6.
  • 33. Qiu S, Bosnyák E, Treff G, Steinacker JM, Nieß AM, Krüger K, et al. Acute exercise-ınduced ırisin release in healthy adults: associations with training status and exercise mode. Eur J Sport Sci, 2018; 18 (9): 1226-33.
  • 34. Ugras S, Algul S. Effects of aerobic exercise ınduced metabolic and cardiac stress on ırisin levels in trained subjects. J Med Bozok, 2020; 10 (1): 186-9.
  • 35. Spiegelman BM. Banting lecture 2012: regulation of adipogenesis: toward new therapeutics for metabolic disease. Diabetes, 2013; 62 (6): 1774-82.
  • 36. Winn NC, Grunewald ZI, Liu Y, Heden TD, Nyhoff LM, Kanaley JA. Plasma irisin modestly increases during moderate and highintensity afternoon exercise in obese females. Plos One, 2017; 12:e0170690.
  • 37. Ozcelik O, Algul S, Deniz M, Baydas F, Tan F. Sabah ve gece yapılan aerobik egzersizin antrenmanlı deneklerde serum irisin düzeyine etkilerinin belirlenmesi. Genel Tip Dergisi, 2017; 27 (1): 1-5.
  • 38. Algul S, Ozçelik O. A new promising pepdide for obesity treatment: Nesfatin-1. FU Sag Bil Tip Derg, 2012; 26: 143-8.

Impact of exercise induced skeletal muscle strain on energy regulatory hormones of irisin and nesfatin-1 in sedentary males

Yıl 2020, Cilt: 77 Sayı: 2, 227 - 232, 01.06.2020

Öz

Objective: Exercise important tool to regulate body energy metabolic system activity by increasing mechanical activity or hormonal effects. In this study, we aimed to examine effects of aerobic exercise on levels of irisin, which increases energy expenditure and nesfatin-1, which suppress energy intake and their connection with CK, which reflects increased muscle injury.Methods: Total of 30 healthy sedentary male preformed 30 min of aerobic running exercise work intensity associated with their anaerobic threshold. Blood samples were taken before and after exercise. Serum irisin nesfatin-1 and creatine kinase CK were analysed.Results: During exercise serum irisin and CK levels increased in all subjects 16.4% and 25.7%, respectively . Despite the mean values increased statistically significant, nesfatin-1 levels did not increased in all subjects 12.1% . There was a positive statistically significant correlation between increase of irisin and CK levels. Conclusion: Consequently, exercise induced skeletal muscle activity may cause increase in CK and irisin levels. Nesfatin-1 hormones may not seem to be exercise-induced hormone and did not correlate with yoğunluktaki aerobik egzersiz metabolik hormonları değiştirerek vücut enerji düzenleyici sistemleri üzerinde faydalı etkiler sağlayabilir

Kaynakça

  • 1. Wang Z, Tsujimoto T,Wakaba K, Mizushima R, Kobayashi H, Tanaka K. Associations of various exercise types with health-related physical fitness: Focus on physical fitness age. J Phys Fitness Sports Med, 2020; 9 (2): 75-2.
  • 2. Nunan D, Mahtani KR, Roberts N, Heneghan C. Physical activity for the prevention and treatment of major chronic disease: an overview of systematic reviews. Syst Rev, 2013; 2: 56.
  • 3. Ozcelik O, Ozkan Y, Algul S, Çolak R. Beneficial effects of training at the anaerobic threshold in addition to pharmacotherapy on weight loss, body composition, and exercise performance in women with obesity. Patient Prefer Adherence, 2015; 9: 999-1004.
  • 4. Leal LG, Lopes MA, Batista ML JR. Physical exerciseınduced myokines and muscle-adipose tissue crosstalk: a review of current knowledge and the ımplications for health and metabolic diseases. Front Physiol, 2018; 9: 1307.
  • 5. Bostrom P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 2012; 481: 463–68.
  • 6. Polyzos SA, Kountouras J, Shields K, Mantzoros CS. Irisin: a renaissance in metabolism? Metabolism, 2013; 62 (8): 1037-44.
  • 7. Perakakis N, Triantafyllou GA, Fernández-Real JM, Huh JY, Park KH, Seufert J, et al. Physiology and role of irisin in glucose homeostasis. Nat Rev Endocrinol, 2017; 13 (6): 324-37.
  • 8. Oh-I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, et al. Identification of nesfatin-1 as a satiety molecule in the hypothala¬mus. Nature, 2006; 443: 709-12.
  • 9. Stengel A, Tache Y. Nesfatin-1--role as possible new potent regulator of food intake. Regul Pept, 2010; 163 (1-3): 18-3.
  • 10. Algul S, Ozkan Y, Ozcelik O. Serum nesfatin-1 levels in patients with different glucose tolerance levels. Physiol Res, 2016; 65 (6): 979-85.
  • 11. Tekin T, Çiçek B, Konyalıgil N. Regulatory peptide nesfatin-1 and its relationship with metabolic syndrome. Eurasian J Med, 2019; 51 (3): 280-4.
  • 12. Yosten GL, Samson WK. Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system. Am J Physiol Regul Integr Comp Physiol, 2009; 297 (2): 330-6.
  • 13. Algul S, Ozcelik O. Evaluating the levels of nesfatin-1 and ghrelin hormones in patients with moderate an severe major depressive disorders. Psychiatry Investig, 2018; 15 (2): 214-8.
  • 14. Daskalopoulou SS, Cooke AB, Gomez YH, Mutter AF, Filippaios A, Mesfum ET, et al. Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. Eur J Endocrinol, 2014; 171 (3): 343-52.
  • 15. Algul S, Ozdenk C, Ozcelik O. Variations in leptin, nesfatin-1 and irisin levels induced by aerobic exercise in young trained and untrained male subjects. Biol Sport, 2017; 34 (4): 339-44.
  • 16. Nygaard H, Slettalokken G, Vegge G, Hollan I, Whist JE, Strand Tor, et al. Irisin in blood increases transiently after single sessions of intense endurance exercise and heavy strength training. Plos One, 2015; 10 (3): e0121367.
  • 17. Kurdiova T, Balaz M, Mayer A, Maderova D, Belan V, Wolfrum C, et al. Exercise- mimicking treatment fails to increase Fndc5 mRNA and irisin secretion in primary human myotubes. Peptides, 2014; 56: 1-7.
  • 18. Raschke S, Elsen M, Gassenhuber H, Sommerfeld M, Schwahn U, Brockmann B, et al. Evidence against a beneficial effect of irisin in humans. Plos One, 2013; 8 (9): e73680.
  • 19. Pekkala S, Wiklund PK, Hulmi JJ, Ahtiainen JP, Horttanainen M, Pöllänen E, et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? J Physiol, 2013; 591 (21): 5393-400.
  • 20. Arıkan S. Effects of acute and chronic exercises on plasma nesfatin-1 levels in young adults. Cyprus J Med Sci, 2020; 5(1): 77-80.
  • 21. Yazici AG. Relationship and interaction between anaerobic sports branches and serum nesfatin-1. Turk J Phys Med Rehab, 2015; 61: 234-40.
  • 22. Ghanbari-Niaki A, Kraemer RR, Soltani R. Plasma nesfatin-1 and glucoregulatory hormone responses to two different anaerobic exercise sessions. Eur J Appl Physiol, 2010;110 (4): 863-8.
  • 23. Algul S, Ozçelik O. Determination of the effects of acute aerobic exercise on nesfatin-1 levels. F.U Sag Bil Tip Derg, 2016; 30 (5): 8-16.
  • 24. Koh TJ. Physiology and mechanisms of skeletal muscle damage. In: P.M. Tiidus (ed.) Skeletal muscle damage and repair. Human Kinetics Champaign IL, 2008; 3-12.
  • 25. Brancaccio P, Maffulli N, Limongelli FM. Creatine kinase monitoring in sport medicine. Br Med Bull, 2007; 81 (82): 209-30.
  • 26. Baird MF, Graham SM, Baker JS, Bickerstaff GF. Creatine-kinase- and exercise-relatedmuscle damage ımplications for muscle performance and recovery. J Nutr Metab, 2012; ID 960363: 13.
  • 27. Kaya H, Özçelik O. Comparison of effectiveness of body mass index and bioelectric impedance analysis methods on body composition in subjects with different ages and sex. F.U Sag Bil Tip Derg, 2009; 23 (1): 1-5.
  • 28. American College of Sports Medicine (ACSM). Guidelines for Exercise Testing and Prescription (9th ed.). Baltimore, MD: Lippincott, Williams and Wilkins, 2014.
  • 29. Huh JY, Siopi A, Mougios V, Park KH, Mantzoros CS. Irisin in response to exercise in humans with and without metabolic syndrome. J Clin Endocrinol Metab, 2015; 100 (3): 453-7.
  • 30. Kraemer RR, Shockett P, Webb ND, Shah U, Castracane VD. A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women. Horm Metab Res, 2014; 46 (2): 150-4.
  • 31. Ozcelik O, Algul S, Yilmaz B. Nesfatin-1 and irisin levels in response to the soccer matches performed in morning, afternoon and at night in young trained male subjects. Cell Mol Biol (Noisy-le-Grand, France), 2018; 64 (10): 130-3.
  • 32. Ozbay S, Ulupınar S, Şebin E, Altınkaynak K. Acute and chronic effects of aerobic exercise on serum ırisin, adropin, and cholesterol levels in the winter season: ındoor training versus outdoor training. Chin J Physiol, 2020; 63 (1): 21-6.
  • 33. Qiu S, Bosnyák E, Treff G, Steinacker JM, Nieß AM, Krüger K, et al. Acute exercise-ınduced ırisin release in healthy adults: associations with training status and exercise mode. Eur J Sport Sci, 2018; 18 (9): 1226-33.
  • 34. Ugras S, Algul S. Effects of aerobic exercise ınduced metabolic and cardiac stress on ırisin levels in trained subjects. J Med Bozok, 2020; 10 (1): 186-9.
  • 35. Spiegelman BM. Banting lecture 2012: regulation of adipogenesis: toward new therapeutics for metabolic disease. Diabetes, 2013; 62 (6): 1774-82.
  • 36. Winn NC, Grunewald ZI, Liu Y, Heden TD, Nyhoff LM, Kanaley JA. Plasma irisin modestly increases during moderate and highintensity afternoon exercise in obese females. Plos One, 2017; 12:e0170690.
  • 37. Ozcelik O, Algul S, Deniz M, Baydas F, Tan F. Sabah ve gece yapılan aerobik egzersizin antrenmanlı deneklerde serum irisin düzeyine etkilerinin belirlenmesi. Genel Tip Dergisi, 2017; 27 (1): 1-5.
  • 38. Algul S, Ozçelik O. A new promising pepdide for obesity treatment: Nesfatin-1. FU Sag Bil Tip Derg, 2012; 26: 143-8.
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

Seda Uğraş Bu kişi benim

Oğuz Özçelik Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 77 Sayı: 2

Kaynak Göster

APA Uğraş, S., & Özçelik, O. (2020). Impact of exercise induced skeletal muscle strain on energy regulatory hormones of irisin and nesfatin-1 in sedentary males. Türk Hijyen Ve Deneysel Biyoloji Dergisi, 77(2), 227-232.
AMA Uğraş S, Özçelik O. Impact of exercise induced skeletal muscle strain on energy regulatory hormones of irisin and nesfatin-1 in sedentary males. Turk Hij Den Biyol Derg. Haziran 2020;77(2):227-232.
Chicago Uğraş, Seda, ve Oğuz Özçelik. “Impact of Exercise Induced Skeletal Muscle Strain on Energy Regulatory Hormones of Irisin and Nesfatin-1 in Sedentary Males”. Türk Hijyen Ve Deneysel Biyoloji Dergisi 77, sy. 2 (Haziran 2020): 227-32.
EndNote Uğraş S, Özçelik O (01 Haziran 2020) Impact of exercise induced skeletal muscle strain on energy regulatory hormones of irisin and nesfatin-1 in sedentary males. Türk Hijyen ve Deneysel Biyoloji Dergisi 77 2 227–232.
IEEE S. Uğraş ve O. Özçelik, “Impact of exercise induced skeletal muscle strain on energy regulatory hormones of irisin and nesfatin-1 in sedentary males”, Turk Hij Den Biyol Derg, c. 77, sy. 2, ss. 227–232, 2020.
ISNAD Uğraş, Seda - Özçelik, Oğuz. “Impact of Exercise Induced Skeletal Muscle Strain on Energy Regulatory Hormones of Irisin and Nesfatin-1 in Sedentary Males”. Türk Hijyen ve Deneysel Biyoloji Dergisi 77/2 (Haziran 2020), 227-232.
JAMA Uğraş S, Özçelik O. Impact of exercise induced skeletal muscle strain on energy regulatory hormones of irisin and nesfatin-1 in sedentary males. Turk Hij Den Biyol Derg. 2020;77:227–232.
MLA Uğraş, Seda ve Oğuz Özçelik. “Impact of Exercise Induced Skeletal Muscle Strain on Energy Regulatory Hormones of Irisin and Nesfatin-1 in Sedentary Males”. Türk Hijyen Ve Deneysel Biyoloji Dergisi, c. 77, sy. 2, 2020, ss. 227-32.
Vancouver Uğraş S, Özçelik O. Impact of exercise induced skeletal muscle strain on energy regulatory hormones of irisin and nesfatin-1 in sedentary males. Turk Hij Den Biyol Derg. 2020;77(2):227-32.