LANTANA CAMARA L.: A NATURAL TREASURE TROVE OF ANTIOXIDANTS AND ANTI-INFLAMMATORY AGENTS

Öz

Lantana camara L. leaves were extracted using solvents of differing polarity—petroleum ether, acetone, and chloroform—to investigate their phytochemical composition, functional groups, and antioxidant potential. Preliminary phytochemical screening revealed a rich presence of bioactive metabolites such as flavonoids, phenolics, alkaloids, tannins, terpenoids, glycosides, and steroids predominantly in acetone and chloroform extracts, while petroleum ether showed limited polarity-associated compounds. Quantitative analysis demonstrated significantly higher total phenolic (54.86 mg GAE/g) and flavonoid content (39.44 mg QE/g) in acetone extracts compared to petroleum ether (8.72 mg GAE/g and 5.31 mg QE/g) and chloroform (28.17 mg GAE/g and 19.25 mg QE/g). Antioxidant assays corroborated these findings: acetone extract exhibited the strongest DPPH radical scavenging activity (IC₅₀ = 41.25 μg/mL), highest ferric reducing antioxidant power (429.55 μmol Trolox equivalents/g), and ABTS inhibition (88.36%). Fourier Transform Infrared (FTIR) spectroscopy confirmed the presence of key functional groups, including hydroxyl, carbonyl, and aromatic moieties, varying with solvent polarity. These results highlight acetone as the most effective solvent for extracting antioxidant-rich phytochemicals from L. camara leaves, emphasizing the plant’s potential as a natural source of therapeutic antioxidants for pharmaceutical and nutraceutical applications.

Anahtar Kelimeler

• Lantana camara
• Bioactive compounds
• Antioxidant activity
• FTIR

LANTANA CAMARA L.: ANTİOKSİDANLAR VE ANTİ-İNFLAMATUAR AJANLARIN DOĞAL HAZİNESİ

Öz

Lantana camara L. yaprakları, fitokimyasal bileşimlerini, fonksiyonel gruplarını ve antioksidan potansiyellerini araştırmak için farklı polariteye sahip çözücüler (petrol eteri, aseton ve kloroform) kullanılarak ekstrakt edildi. Ön fitokimyasal tarama, aseton ve kloroform özütlerinde baskın olarak flavonoidler, fenolikler, alkaloidler, tanenler, terpenoidler, glikozitler ve steroidler gibi biyoaktif metabolitlerin zengin bir varlığını ortaya koyarken, petrol eteri sınırlı polariteyle ilişkili bileşikler gösterdi. Kantitatif analiz, aseton özütlerinde petrol eteri (8,72 mg GAE/g ve 5,31 mg QE/g) ve kloroform (28,17 mg GAE/g ve 19,25 mg QE/g) ile karşılaştırıldığında önemli ölçüde daha yüksek toplam fenolik (54,86 mg GAE/g) ve flavonoid içeriği (39,44 mg QE/g) gösterdi. Antioksidan analizleri bu bulguları doğruladı: aseton özütü en güçlü DPPH radikal temizleme aktivitesini (IC₅₀ = 41,25 μg/mL), en yüksek ferrik indirgeyici antioksidan gücünü (429,55 μmol Trolox eşdeğeri/g) ve ABTS inhibisyonunu (%88,36) gösterdi. Fourier Dönüşümlü Kızılötesi (FTIR) spektroskopisi, çözücü polaritesine göre değişen hidroksil, karbonil ve aromatik gruplar dahil olmak üzere temel fonksiyonel grupların varlığını doğruladı. Bu sonuçlar, asetonu L. camara yapraklarından antioksidan açısından zengin fitokimyasalları çıkarmak için en etkili çözücü olarak vurgulayarak, bitkinin farmasötik ve nutrasötik uygulamalar için doğal bir terapötik antioksidan kaynağı olarak potansiyelini vurguladı.

Anahtar Kelimeler

• Lantana camara
• Biyoaktif bileşikler
• Antioksidan aktivite
• FTIR

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