Parkinson Hastalığının Deneysel Nörotoksin Modelleri

Yıl 2023, Cilt: 4 Sayı: 3, 85 - 92, 30.12.2023

Elif Karabacak

Öz

Parkinson hastalığı (PH), bazal gangliyonlardaki dopaminin azalması sonucu gelişen
nörodejeneratif bir hastalıktır. Hastalığın patogenezi tam olarak anlaşılamamıştır.
Ancak PH‟nın temelinde nöroinflamasyonun olduğu bilinen bir gerçektir. Deneysel
modellerde kullanılan bütün nörotoksinler, nigrostriatal yolakta nöroinflamasyon
cevabını oluşturmaktadır. Ayrıca, bradikinezi, rijidite ve gönüllü harekete
başlama/sıralama bozukluğu da meydana gelmektedir. Dolayısıyla, PH için olası
terapötikleri değerlendirmek, hastalıkla ilişkili patolojileri anlamak için hayvan
modelleri gereklidir. Motor bozuklukları ölçmede basit ve kolay olması da hayvan
modelleriyle çalışmayı daha cazip hale getirmiştir. Bu derlemede, PH
araştırmalarında kullanılan nörotoksin hayvan modelleri incelenmiştir.

Anahtar Kelimeler

Parkinson hastalığı, Nörotoksinler, Hayvan modelleri

Kaynakça

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