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RADIATION DOSE DETERMINATION BY USING NAILS WITH ESR BIODOSIMETRY TECHNIQUE

Yıl 2020, Cilt: 32 Sayı: 1, 43 - 58, 23.09.2020

Öz

For many years, the number of ESR studies on nails have increased as a mean of rapid and accurate biodosimetry. The most important outcome of these studies is the identification of a stable radiation-induced signal (RIS5) component in nails by the French Radioprotection and Nuclear Safety Institute (IRSN). The other protocol was proposed by Sholom and McKeever funding from Dartmouth ESR center, with American National Institute of Health (NIH) funding. In this study, the results of three approaches on nail dosimetry were presented: two were based on the described protocols of IRSN and Dartmouth and the other used the classical added dose method. Nail samples were collected from a donor irradiated with 137Cs gamma rays (0.5 kGy/h). EPR measurements were carried out using a Bruker e-scan X-band EPR spectrometer. Samples irradiated up to doses of 25, 30, 85 and 168 Gy were used to construct the added dose-response curves in steps of 5 and 10 Gy. The reported intensities of RIS5 and center field signal (near g=2.004) were derived from peak-to-peak distance of the EPR signal (Figures 1 and 4). To test last protocol published in 2016, nail samples were irradiated by Co-60 gamma rays at 2 and 5 Gy as accident doses. The ESR signal intensities were recorded to use in formula given in proposed protocol.In the first protocol, differences between dose saturation points of exposed and unexposed samples which determine the accident doses were found as 15 Gy for the first group and 10 Gy for the second group (Figures 2 and 3). On the other hand, in the second protocol, the EPR signal intensity increased with increasing added doses. The experimentally measured EPR signal intensity values (y) fitted well by polynomial function and the extrapolated doses were calculated to be 13.89 and 22.19 Gy for 10 and 15 Gy accident doses, repectively (Figures 5 and 6). Lastly, according to Dartmouth center protocol, the mean accident doses were calculated as 2.18 and 4.5 Gy for 2 and 5 Gy accident doses, respectively. IRSN protocol using the RIS5 component and Dartmouth protocol were found to be successful methods for the evaluation of dose to fingernails exposed high-doses. However, classical approach using center field EPR signal given extrapolated doses in error of 38.9 and 47.9 percent was found to be unsuccessful. Further studies should be planned to test the IRSN and Dartmouth approaches for lower accident doses on more samples from different individuals.

Destekleyen Kurum

TAEK

Proje Numarası

A3.H2.F8

Kaynakça

  • 1) Black P.J. & Swarts S.G. (2010). Ex-vivo analysis of irradiated fingernails: chemical yields and properties of radiation-induced and mechanically-induced radicals. Health Physics. 98, 301–308.
  • 2) Brady, J.M., Aarestad, N.O. & Swartz, H.M. (1968). In vivo dosimetry by electron spin resonance spectroscopy. Health Physics. 15, 43-47.
  • 3) Dalgarno B.G. & McClymont J.D. (1989). Evaluation of ESR as a radiation accident dosimetry technique. Applied Radiatin and Isotopes. 40, 1013–1020.
  • 4) He X., Gui J., Matthews T.P., Williams B.B., Swarts S.G., Grinberg O., Sidabras J., Wilcox D.E. & Swartz H.M. (2011). Advances towards using finger/toenail dosimetry to triage a large population after potential exposure to ionizing radiation. Radiation Measurements. 46, 882–887.
  • 5) International Atomic Energy Agency. The radiological accident in Chilca. Vienna: IAEA; 2012.ISO/FDIS 13304-1. (2013). Radiological protection—minimum criteria for electron paramagnetic resonance (EPR) spectroscopy for retrospective dosimetry of ionizing radiation—part 1: general principles. International Standard.
  • 6) Marciniak A., Ciesielski B.A. & Prawdzik-Dampc A. (2014). The effect of dose and water treatment on EPR signals in irradiated fingernails. Radiation Protection Dosimetry.162, 6-9.
  • 7) Reyes R.A., Romanyukha A., Trompier F., Mitchell C.A., Clairand I., De T., Benevides L.A. & Swartz H.M. (2008). Electron paramagnetic resonance in human fingernails: the sponge model implication. Radiation and Environmental Biophysics. 47, 515–526.
  • 8) Reyes R.A., Romanyukha A., Olsen C., Trompier F. & Benevides L.A. (2009). Electron paramagnetic resonance in irradiated fingernails: variability of dose dependence and possibilities of initial dose assessment. Radiation and Environmental Biophysics. 48, 295–310.
  • 9) Reyes R.A., Trompier F. & Romanyukha A. (2012). Study of the stability of signals after irradiation of fingernail samples. Health Physics. 103, 175–180.
  • 10) Romanyukha A., Trompier F., LeBlanc B., Calas C., Clairand I., Mitchell C.A., Smirniotopoulos J.G. & Swartz H.M. (2007a). EPR dosimetry in chemically treated fingernails. Radiation Measurements. 42, 1110–1113.
  • 11) Romanyukha A., Mitchell C.A., Schauer D.A., Romanyukha L. & Swartz H.M. (2007b). Q-band EPR biodosimetry in tooth enamel microsamples: feasibility test and comparison with X-band. Health Physics. 93, 631–635.
  • 12) Romanyukha A., Reyes R.A., Trompier F. & Benevides LA. (2010). Fingernail dosimetry: current status and perspectives. Health Physics. 98, 296–300.
  • 13) Romanyukha A., Trompier F., Reyes R.A., Christensen D.M., Iddins C.J. & Sugarman S.L. (2014). Electron paramagnetic resonance radiation dose assessment in fingernails of the victim exposed to high dose as result of an accident. Radiation and Environmental Biophysics. 53, 755-762.
  • 14) Sholom S. & McKeever S.W.S. (2016). Emergency EPR dosimetry technique using vacuum-stored dry nails. Radiation Measurements. (1-7).
  • 15) Symons M., Chandra H. & Wyatt J. (1995). Electron paramagnetic resonance spectra of irradiated finger-nails: a possible measure of accidental exposure. Radiation Protection Dosimetry. 58, 11–15.
  • 16) Trompier F., Romanyukha A., Reyes R., Vezin H., Queinnec F. & Gourier D. (2014a). State of the art in nail dosimetry: free radicals identification and reaction mechanisms. Radiation and Environmental Biophysics. DOI 10.1007/s00411-014-0512-2
  • 17) Trompier F., Kornak L., Calas C., Romanyukha A., LeBlanc B., Mitchell C.A., Swartz H.M. & Clairand I. (2007). Protocol for emergency EPR dosimetry in fingernails. Radiation Measurements. 42, 1085–1088.
  • 18) Trompier F., Romanyukha A., Kornak L., Calas C., LeBlanc B., Mitchell C., Swartz H. & Clairand I. (2009). Electron paramagnetic resonance radiation dosimetry in fingernails. Radiation Measurements. 44, 6–10.
  • 19) Trompier F., Queinnec F., Bey E., De Revel T., Lataillade J.J., Clairand I., Benderitter M. & Depois J.F.B. (2014b). EPR retrospective dosimetry with fingernails: report on first application cases. Health Physics. 106:798-805. doi: 10.1097/HP.0000000000000110.
  • 20) Trompier F., Bey E., Queinnec F., Bottollier-Depois J.F. & Clairand I. (2013). First applications of Q-band EPR for radiation accident dosimetry. In: The joint international symposium on EPR dosimetry and dating and the international conference on biological dosimetry. Book of Abstracts. Leiden, 144.
  • 21) Wilcox D.E., He X., Gui J., Ruuge A.E., Li H., Williams B.B. & Swartz H.M. (2010). Dosimetry based on EPR spectral analysis of fingernail clippings. Health Physics. 98, 309–317.
Yıl 2020, Cilt: 32 Sayı: 1, 43 - 58, 23.09.2020

Öz

Proje Numarası

A3.H2.F8

Kaynakça

  • 1) Black P.J. & Swarts S.G. (2010). Ex-vivo analysis of irradiated fingernails: chemical yields and properties of radiation-induced and mechanically-induced radicals. Health Physics. 98, 301–308.
  • 2) Brady, J.M., Aarestad, N.O. & Swartz, H.M. (1968). In vivo dosimetry by electron spin resonance spectroscopy. Health Physics. 15, 43-47.
  • 3) Dalgarno B.G. & McClymont J.D. (1989). Evaluation of ESR as a radiation accident dosimetry technique. Applied Radiatin and Isotopes. 40, 1013–1020.
  • 4) He X., Gui J., Matthews T.P., Williams B.B., Swarts S.G., Grinberg O., Sidabras J., Wilcox D.E. & Swartz H.M. (2011). Advances towards using finger/toenail dosimetry to triage a large population after potential exposure to ionizing radiation. Radiation Measurements. 46, 882–887.
  • 5) International Atomic Energy Agency. The radiological accident in Chilca. Vienna: IAEA; 2012.ISO/FDIS 13304-1. (2013). Radiological protection—minimum criteria for electron paramagnetic resonance (EPR) spectroscopy for retrospective dosimetry of ionizing radiation—part 1: general principles. International Standard.
  • 6) Marciniak A., Ciesielski B.A. & Prawdzik-Dampc A. (2014). The effect of dose and water treatment on EPR signals in irradiated fingernails. Radiation Protection Dosimetry.162, 6-9.
  • 7) Reyes R.A., Romanyukha A., Trompier F., Mitchell C.A., Clairand I., De T., Benevides L.A. & Swartz H.M. (2008). Electron paramagnetic resonance in human fingernails: the sponge model implication. Radiation and Environmental Biophysics. 47, 515–526.
  • 8) Reyes R.A., Romanyukha A., Olsen C., Trompier F. & Benevides L.A. (2009). Electron paramagnetic resonance in irradiated fingernails: variability of dose dependence and possibilities of initial dose assessment. Radiation and Environmental Biophysics. 48, 295–310.
  • 9) Reyes R.A., Trompier F. & Romanyukha A. (2012). Study of the stability of signals after irradiation of fingernail samples. Health Physics. 103, 175–180.
  • 10) Romanyukha A., Trompier F., LeBlanc B., Calas C., Clairand I., Mitchell C.A., Smirniotopoulos J.G. & Swartz H.M. (2007a). EPR dosimetry in chemically treated fingernails. Radiation Measurements. 42, 1110–1113.
  • 11) Romanyukha A., Mitchell C.A., Schauer D.A., Romanyukha L. & Swartz H.M. (2007b). Q-band EPR biodosimetry in tooth enamel microsamples: feasibility test and comparison with X-band. Health Physics. 93, 631–635.
  • 12) Romanyukha A., Reyes R.A., Trompier F. & Benevides LA. (2010). Fingernail dosimetry: current status and perspectives. Health Physics. 98, 296–300.
  • 13) Romanyukha A., Trompier F., Reyes R.A., Christensen D.M., Iddins C.J. & Sugarman S.L. (2014). Electron paramagnetic resonance radiation dose assessment in fingernails of the victim exposed to high dose as result of an accident. Radiation and Environmental Biophysics. 53, 755-762.
  • 14) Sholom S. & McKeever S.W.S. (2016). Emergency EPR dosimetry technique using vacuum-stored dry nails. Radiation Measurements. (1-7).
  • 15) Symons M., Chandra H. & Wyatt J. (1995). Electron paramagnetic resonance spectra of irradiated finger-nails: a possible measure of accidental exposure. Radiation Protection Dosimetry. 58, 11–15.
  • 16) Trompier F., Romanyukha A., Reyes R., Vezin H., Queinnec F. & Gourier D. (2014a). State of the art in nail dosimetry: free radicals identification and reaction mechanisms. Radiation and Environmental Biophysics. DOI 10.1007/s00411-014-0512-2
  • 17) Trompier F., Kornak L., Calas C., Romanyukha A., LeBlanc B., Mitchell C.A., Swartz H.M. & Clairand I. (2007). Protocol for emergency EPR dosimetry in fingernails. Radiation Measurements. 42, 1085–1088.
  • 18) Trompier F., Romanyukha A., Kornak L., Calas C., LeBlanc B., Mitchell C., Swartz H. & Clairand I. (2009). Electron paramagnetic resonance radiation dosimetry in fingernails. Radiation Measurements. 44, 6–10.
  • 19) Trompier F., Queinnec F., Bey E., De Revel T., Lataillade J.J., Clairand I., Benderitter M. & Depois J.F.B. (2014b). EPR retrospective dosimetry with fingernails: report on first application cases. Health Physics. 106:798-805. doi: 10.1097/HP.0000000000000110.
  • 20) Trompier F., Bey E., Queinnec F., Bottollier-Depois J.F. & Clairand I. (2013). First applications of Q-band EPR for radiation accident dosimetry. In: The joint international symposium on EPR dosimetry and dating and the international conference on biological dosimetry. Book of Abstracts. Leiden, 144.
  • 21) Wilcox D.E., He X., Gui J., Ruuge A.E., Li H., Williams B.B. & Swartz H.M. (2010). Dosimetry based on EPR spectral analysis of fingernail clippings. Health Physics. 98, 309–317.
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Metroloji,Uygulamalı ve Endüstriyel Fizik
Bölüm Articles
Yazarlar

Semra Tepe Çam

Proje Numarası A3.H2.F8
Yayımlanma Tarihi 23 Eylül 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 32 Sayı: 1

Kaynak Göster

APA Tepe Çam, S. (2020). RADIATION DOSE DETERMINATION BY USING NAILS WITH ESR BIODOSIMETRY TECHNIQUE. Turkish Journal of Nuclear Sciences, 32(1), 43-58.
AMA Tepe Çam S. RADIATION DOSE DETERMINATION BY USING NAILS WITH ESR BIODOSIMETRY TECHNIQUE. Turkish Journal of Nuclear Sciences. Eylül 2020;32(1):43-58.
Chicago Tepe Çam, Semra. “RADIATION DOSE DETERMINATION BY USING NAILS WITH ESR BIODOSIMETRY TECHNIQUE”. Turkish Journal of Nuclear Sciences 32, sy. 1 (Eylül 2020): 43-58.
EndNote Tepe Çam S (01 Eylül 2020) RADIATION DOSE DETERMINATION BY USING NAILS WITH ESR BIODOSIMETRY TECHNIQUE. Turkish Journal of Nuclear Sciences 32 1 43–58.
IEEE S. Tepe Çam, “RADIATION DOSE DETERMINATION BY USING NAILS WITH ESR BIODOSIMETRY TECHNIQUE”, Turkish Journal of Nuclear Sciences, c. 32, sy. 1, ss. 43–58, 2020.
ISNAD Tepe Çam, Semra. “RADIATION DOSE DETERMINATION BY USING NAILS WITH ESR BIODOSIMETRY TECHNIQUE”. Turkish Journal of Nuclear Sciences 32/1 (Eylül 2020), 43-58.
JAMA Tepe Çam S. RADIATION DOSE DETERMINATION BY USING NAILS WITH ESR BIODOSIMETRY TECHNIQUE. Turkish Journal of Nuclear Sciences. 2020;32:43–58.
MLA Tepe Çam, Semra. “RADIATION DOSE DETERMINATION BY USING NAILS WITH ESR BIODOSIMETRY TECHNIQUE”. Turkish Journal of Nuclear Sciences, c. 32, sy. 1, 2020, ss. 43-58.
Vancouver Tepe Çam S. RADIATION DOSE DETERMINATION BY USING NAILS WITH ESR BIODOSIMETRY TECHNIQUE. Turkish Journal of Nuclear Sciences. 2020;32(1):43-58.