Araştırma Makalesi
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Yıl 2021, Cilt 33, Sayı 1, 15 - 25, 18.11.2021

Öz

Kaynakça

  • 1) Aslan, N. and Özçayan, G., (2019). Radionuclidic impurity determination of 99mTc and evaluation of uncertainty budget. INSINUME 2019-8th International Symposium on IN SItu Nuclear MEtrology as a tool for radioecology (Full-text book), 19-25, Kusadası-Aydın/Turkey. https://cocukergen2020.com/gorseller/files/insume-fulltext-kitabi-min.pdf
  • 2) Boon, K.A. and Ramsey, M.H. (2012). Judging the fitness of on-site measurements by their uncertainty, including the contribution from sampling. Science of the Total Environment, 419, 196-207. doi:10.1016/j.scitotenv.2011.12.001
  • 3) European Pharmacopeia (2008). Sodium Pertechnetate (99mTc) Injection (Fission), European Pharmacopeia 8.0, 01/2008:0124 corrected 7, 1090-1091.
  • 4) Hou, X. (2017). Determination of radionuclidic impurities in 99mTc eluate from 99Mo/99mTc generator for quality control. Journal of Radioanalytical and Nuclear Chemistry, 314, 659–668. doi:10.1007/s10967-017-5369-9
  • 5) IAEA Nuclear Energy Series, (2013). Non-HEU production technologies for Molybdenum-99 and Technetium-99m. https://www-pub.iaea.org/MTCD/Publications/PDF/Pub1589_web.pdf
  • 6) International Organization for Standardization, ISO (2008). Evaluation of measurement data-Guide to the expression of uncertainty in measurement. https://www.bipm.org/utils/common/documents/jcgm/JCGM_100_2008_E.pdf
  • 7) International Organization for Standardization (2003). Medical laboratories–particular requirements for quality and competence.
  • 8) Jerome, S. M. and Eccles, J. L., 2007. General concepts for traceability in environmental radioactivity monitoring. Metrologia, 44, S133–S139. doi:10.1088/0026-1394/44/4/S17 9) National Pathology Accreditation Advisory Council (2007). Requirements for the estimation of measurement uncertainty. https://www.apfcb.org/umnpaac.pdf
  • 10) Taylor, P. D., Ramsey, M. H. and Potts, P.J. (2005). Spatial contaminant heterogeneity: quantification with a scale of measurement at contrasting sites. Journal of Environmental Monitoring, 7, 1364–1370. doi:10.1039/b511636h

QUANTIFYING THE RADIONUCLICID IMPURITIES AND UNCERTAINTY COMPONENTS OF 99mTc ELUATE BY LIQUID SCINTILLATION SPECTROMETRIC METHOD

Yıl 2021, Cilt 33, Sayı 1, 15 - 25, 18.11.2021

Öz

Radyonüklidik safsızlıklar, özellikle uzun ömürlü saf alfa ve beta yayıcılar, tıbbi görüntüleme ve tanıda kullanılan radyoizotopların kalitesiyle ilgili başlıca endişelerdir. Hastanın genel radyasyon dozuna önemli ölçüde katkıda bulundukları için, kabul edilebilir kalite kontrol (QC) parametrelerine sahip bir ürüne sahip olmak önemlidir. Bu çalışmada, 99Mo/99mTc jeneratöründen sağılan 99mTc eluattındaki radyonüklidik safsızlıklar, 89Sr, 90Sr ve toplam alfa/beta yayıcıların ardışık olarak ayrılması ve hemen ardından Sıvı Sintilasyon Sayımı sisteminde yapılan hassas ölçümlerle tayin edilmiştir. Ardışık ayırma yönteminin, doğrulaması radyonüklidlerin standart çözeltileri kullanılarak yapılmış ve ölçüm belirsizliği parametreleri ayrıntılı olarak değerlendirilmiştir. Aktivite derişiminin hesaplanan belirsizliği, bileşik standart belirsizlik olarak verilmiştir. Belirsizlik bütçesine katkıda bulunan parametreler sırasıyla sayım istatistikleri, detektör verimi, pulse-şekil ayırımı (PSA), numune kütlesi ve radyoaktif standart çözeltilerinin aktivitelerindeki belirsizliklerdir. En büyük katkı beklendiği gibi sayım istatistiklerinden gelmektedir.

Kaynakça

  • 1) Aslan, N. and Özçayan, G., (2019). Radionuclidic impurity determination of 99mTc and evaluation of uncertainty budget. INSINUME 2019-8th International Symposium on IN SItu Nuclear MEtrology as a tool for radioecology (Full-text book), 19-25, Kusadası-Aydın/Turkey. https://cocukergen2020.com/gorseller/files/insume-fulltext-kitabi-min.pdf
  • 2) Boon, K.A. and Ramsey, M.H. (2012). Judging the fitness of on-site measurements by their uncertainty, including the contribution from sampling. Science of the Total Environment, 419, 196-207. doi:10.1016/j.scitotenv.2011.12.001
  • 3) European Pharmacopeia (2008). Sodium Pertechnetate (99mTc) Injection (Fission), European Pharmacopeia 8.0, 01/2008:0124 corrected 7, 1090-1091.
  • 4) Hou, X. (2017). Determination of radionuclidic impurities in 99mTc eluate from 99Mo/99mTc generator for quality control. Journal of Radioanalytical and Nuclear Chemistry, 314, 659–668. doi:10.1007/s10967-017-5369-9
  • 5) IAEA Nuclear Energy Series, (2013). Non-HEU production technologies for Molybdenum-99 and Technetium-99m. https://www-pub.iaea.org/MTCD/Publications/PDF/Pub1589_web.pdf
  • 6) International Organization for Standardization, ISO (2008). Evaluation of measurement data-Guide to the expression of uncertainty in measurement. https://www.bipm.org/utils/common/documents/jcgm/JCGM_100_2008_E.pdf
  • 7) International Organization for Standardization (2003). Medical laboratories–particular requirements for quality and competence.
  • 8) Jerome, S. M. and Eccles, J. L., 2007. General concepts for traceability in environmental radioactivity monitoring. Metrologia, 44, S133–S139. doi:10.1088/0026-1394/44/4/S17 9) National Pathology Accreditation Advisory Council (2007). Requirements for the estimation of measurement uncertainty. https://www.apfcb.org/umnpaac.pdf
  • 10) Taylor, P. D., Ramsey, M. H. and Potts, P.J. (2005). Spatial contaminant heterogeneity: quantification with a scale of measurement at contrasting sites. Journal of Environmental Monitoring, 7, 1364–1370. doi:10.1039/b511636h

Ayrıntılar

Birincil Dil İngilizce
Konular Fizik, Uygulamalı
Bölüm Araştırma Makalesi
Yazarlar

Nazife ASLAN> (Sorumlu Yazar)
ANKARA HACI BAYRAM VELİ ÜNİVERSİTESİ, POLATLI FEN-EDEBİYAT FAKÜLTESİ, KİMYA BÖLÜMÜ
0000-0002-2622-5908
Türkiye


Gülten ÖZÇAYAN>
Türkiye Enerji, Nükleer ve Maden Araştırma Kurumu
0000-0001-9773-4569
Türkiye

Destekleyen Kurum TÜRKİYE ATOM ENERJİSİ KURUMU VE ECZACIBAŞI MONROL ARASINDA "99mTc KALİTE KONTROLÜ KAPSAMINDA ALFA VE BETA IŞINI YAYICISI (89Sr, 90Sr VE TOPLAM ALFA-BETA) RADYONÜKLİDİK SAFSIZLIKLARIN BELİRLENMESİ İÇİN NUMUNE HAZIRLAMA VE LSC’DE ÖLÇÜM METOTLARI GELİŞTİRİLMESİNE" İLİŞKİN İŞBİRLİĞİ PROTOKOLÜ
Yayımlanma Tarihi 18 Kasım 2021
Yayınlandığı Sayı Yıl 2021, Cilt 33, Sayı 1

Kaynak Göster

Bibtex @araştırma makalesi { tjns911414, journal = {Turkish Journal of Nuclear Sciences}, eissn = {2791-7185}, address = {Türkiye Atom Enerjisi Kurumu Mustafa Kemal Mahallesi Dumlupınar Bulvarı, No: 192 Çankaya / Ankara 06510}, publisher = {T.C. Türkiye Enerji, Nükleer ve Maden Araştırma Kurumu}, year = {2021}, volume = {33}, number = {1}, pages = {15 - 25}, title = {QUANTIFYING THE RADIONUCLICID IMPURITIES AND UNCERTAINTY COMPONENTS OF 99mTc ELUATE BY LIQUID SCINTILLATION SPECTROMETRIC METHOD}, key = {cite}, author = {Aslan, Nazife and Özçayan, Gülten} }
APA Aslan, N. & Özçayan, G. (2021). QUANTIFYING THE RADIONUCLICID IMPURITIES AND UNCERTAINTY COMPONENTS OF 99mTc ELUATE BY LIQUID SCINTILLATION SPECTROMETRIC METHOD . Turkish Journal of Nuclear Sciences , 33 (1) , 15-25 . Retrieved from https://dergipark.org.tr/tr/pub/tjns/issue/65847/911414
MLA Aslan, N. , Özçayan, G. "QUANTIFYING THE RADIONUCLICID IMPURITIES AND UNCERTAINTY COMPONENTS OF 99mTc ELUATE BY LIQUID SCINTILLATION SPECTROMETRIC METHOD" . Turkish Journal of Nuclear Sciences 33 (2021 ): 15-25 <https://dergipark.org.tr/tr/pub/tjns/issue/65847/911414>
Chicago Aslan, N. , Özçayan, G. "QUANTIFYING THE RADIONUCLICID IMPURITIES AND UNCERTAINTY COMPONENTS OF 99mTc ELUATE BY LIQUID SCINTILLATION SPECTROMETRIC METHOD". Turkish Journal of Nuclear Sciences 33 (2021 ): 15-25
RIS TY - JOUR T1 - QUANTIFYING THE RADIONUCLICID IMPURITIES AND UNCERTAINTY COMPONENTS OF 99mTc ELUATE BY LIQUID SCINTILLATION SPECTROMETRIC METHOD AU - Nazife Aslan , Gülten Özçayan Y1 - 2021 PY - 2021 N1 - DO - T2 - Turkish Journal of Nuclear Sciences JF - Journal JO - JOR SP - 15 EP - 25 VL - 33 IS - 1 SN - -2791-7185 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Nuclear Sciences QUANTIFYING THE RADIONUCLICID IMPURITIES AND UNCERTAINTY COMPONENTS OF 99mTc ELUATE BY LIQUID SCINTILLATION SPECTROMETRIC METHOD %A Nazife Aslan , Gülten Özçayan %T QUANTIFYING THE RADIONUCLICID IMPURITIES AND UNCERTAINTY COMPONENTS OF 99mTc ELUATE BY LIQUID SCINTILLATION SPECTROMETRIC METHOD %D 2021 %J Turkish Journal of Nuclear Sciences %P -2791-7185 %V 33 %N 1 %R %U
ISNAD Aslan, Nazife , Özçayan, Gülten . "QUANTIFYING THE RADIONUCLICID IMPURITIES AND UNCERTAINTY COMPONENTS OF 99mTc ELUATE BY LIQUID SCINTILLATION SPECTROMETRIC METHOD". Turkish Journal of Nuclear Sciences 33 / 1 (Kasım 2021): 15-25 .
AMA Aslan N. , Özçayan G. QUANTIFYING THE RADIONUCLICID IMPURITIES AND UNCERTAINTY COMPONENTS OF 99mTc ELUATE BY LIQUID SCINTILLATION SPECTROMETRIC METHOD. Turkish Journal of Nuclear Sciences. 2021; 33(1): 15-25.
Vancouver Aslan N. , Özçayan G. QUANTIFYING THE RADIONUCLICID IMPURITIES AND UNCERTAINTY COMPONENTS OF 99mTc ELUATE BY LIQUID SCINTILLATION SPECTROMETRIC METHOD. Turkish Journal of Nuclear Sciences. 2021; 33(1): 15-25.
IEEE N. Aslan ve G. Özçayan , "QUANTIFYING THE RADIONUCLICID IMPURITIES AND UNCERTAINTY COMPONENTS OF 99mTc ELUATE BY LIQUID SCINTILLATION SPECTROMETRIC METHOD", Turkish Journal of Nuclear Sciences, c. 33, sayı. 1, ss. 15-25, Kas. 2021