ACTN3 R577X Polymorphism and Anaerobic Performance in Ultimate Frisbee Players: A Preliminary Study

Abstract

Purpose: ACTN3 R577X polymorphism is a frequently studied gene polymorphism associated with athletic performance. Studies have demonstrated a strong association between the 577RR genotype and sprint and power-based sports. Ultimate Frisbee (UF) is a physically demanding sport requiring aerobic and anaerobic skills. This study aimed to evaluate the relationship between the ACTN3 R577X polymorphism and the anaerobic power capabilities of UF players. Methods: The study included 30 UF players in the study group (mean age ± SD 21.03 ± 2.04 years) and 30 volunteers in the control group (mean age ± SD 22.17 ± 1.39 years). Anaerobic power was assessed using vertical jump, running-based anaerobic sprint (RAST), triple hop, and closed kinetic chain upper extremity tests. Blood samples were genotyped using real-time polymerase chain reaction. RR, RX, and XX represent homozygous dominant, heterozygous dominant, and recessive genotypes, respectively. Results: Fatigue Index (FI) data from RAST test results was the only variable that differed between study and control groups (Study Group: 6.02 ± 3.52 vs. Control Group: 4.17 ± 1.71 watts/sec, p = 0.012). There was no statistically significant difference between the study and control groups in vertical jump, triple hop, and closed kinetic chain upper extremity test results. No statistically significant difference was found in anaerobic performance tests among the genotype groups in UF players. Conclusion: In this study conducted with limited sample size, the anaerobic performance of UF players was not found to be associated with ACTN3 R577X polymorphism. However, performing the same screening in larger sample groups in future studies may yield more efficient results.

Keywords

• ACTN3
• athletic performance
• genomics
• ultimate frisbee

Ultimate Frisbee Oyuncularında ACTN3 R577X Polimorfizmi ve Anaerobik Performans: Bir Ön Çalışma

Öz

Amaç: ACTN3 R577X polimorfizmi, atletik performansla ilişkili olarak sıklıkla çalışılan bir gen polimorfizmidir. Çok sayıda çalışma, 577RR genotipi ile sprint ve güce dayalı sporlar arasında güçlü bir ilişki olduğunu göstermiştir. Ultimate Frisbee (UF) hem aerobik hem de anaerobik beceriler gerektiren fiziksel olarak zorlayıcı bir spordur. Bu çalışmanın amacı, ACTN3 R577X polimorfizmi ile UF oyuncularının anaerobik güç yetenekleri arasındaki ilişkiyi değerlendirmektir. Yöntem: Çalışmaya çalışma grubunda 30 UF oyuncusu (ortalama yaş ± SD 21.03 ± 2.04 yıl) ve kontrol grubunda 30 gönüllü (ortalama yaş ± SD 22.17 ± 1.39 yıl) dahil edildi. Anaerobik güç dikey sıçrama, koşuya dayalı anaerobik sprint (RAST), üçlü sıçrama ve kapalı kinetik zincir üst ekstremite testleri kullanılarak değerlendirilmiştir. Kan örnekleri gerçek zamanlı polimeraz zincir reaksiyonu kullanılarak genotiplendirilmiştir. RR, RX ve XX sırasıyla homozigot dominant, heterozigot dominant ve resesif genotipleri temsil etmektedir. Sonuçlar: RAST testi sonuçlarından elde edilen Yorgunluk İndeksi (FI) verileri çalışma ve kontrol grupları arasında farklılık gösteren tek değişkendi (Çalışma Grubu: 6.02 ± 3.52 vs Kontrol Grubu: 4,17 ± 1,71 watt/sn, p = 0,012). Dikey sıçrama, üçlü sıçrama ve kapalı kinetik zincir üst ekstremite test sonuçlarında çalışma ve kontrol grupları arasında istatistiksel olarak anlamlı bir fark bulunmamıştır. UF oyuncularının genotip grupları arasında anaerobik performans testlerinde istatistiksel olarak anlamlı bir fark bulunmamıştır. Tartışma: Kısıtlı örneklem sayısı ile yapılan bu çalışmada, UF oyuncularının anaerobik performansı ACTN3 R577X polimorfizmi ile ilişkili bulunmamıştır. Ancak gelecek çalışmalarda aynı taramanın daha büyük örneklem gruplarında yapılması daha verimli sonuçlar verebilir.

Anahtar Kelimeler

• ACTN3
• atletik performans
• genomik
• ultimate frizbi

Kaynakça

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