Öz
Anafilaksi, anestezi sırasında gelişebilen nadir ancak potansiyel olarak yaşamı tehdit eden sistemik bir aşırı duyarlılık reaksiyonudur (1). Anestezi altında ortaya çıktığında tanı ve tedavi gecikebilir. En yaygın nedenler arasında nöromüsküler bloke edici ajanlar, antibiyotikler, lateks ve nadiren proton pompa inhibitörleri yer alır (2). Bu olguda, spinal anestezi altında intravenöz pantoprazol uygulanmasını takiben gelişen bir anafilaktik reaksiyon sunulmuştur.
Anahtar Kelimeler
Anafilaksi Pantoprazol Proton pompa inhibitörü Spinal anestezi Triptaz
Kaynakça
- Harper NJN, Cook TM, Garcez T, Farmer L, Floss K, Marinho S, Torevell H, Warner A, Ferguson K, Hitchman J, Egner W, Kemp H, Thomas M, Lucas DN, Nasser S, Karanam S, Kong KL, Farooque S, Bellamy M, McGuire N. Anaesthesia, surgery, and life-threatening allergic reactions: Epidemiology and clinical features of perioperative anaphylaxis in the 6th National Audit Project (NAP6). Br J Anaesth. 2018;121(1):159-171. doi:10.1016/j.bja.2018.04.014
- Low AE, McEwan JC, Karanam S, North J, Kong KL. Anaesthesia-associated hypersensitivity reactions: Seven years’ data from a British bi-specialty clinic. Anaesthesia. 2016;71(1):76-84. doi:10.1111/anae.13273
- Dewachter P, Savic L. Perioperative anaphylaxis: pathophysiology, clinical presentation and management. BJA Educ. 2019;19(10):313-320. doi:10.1016/j.bjae.2019.06.00
- Telaku S, Veliu A, Zenelaj Q, Telaku M, Fejza H, Alidema F. Anaphylaxis caused by taking pantoprazole: Case series. Eur J Case Rep Intern Med. 2023;10(9):004017. doi:10.12890/2023_004017. PMID: 37680781; PMCID: PMC10482135.
- Osman BM, Maga JM, Baquero SM. Case report: Management of differential diagnosis and treatment of severe anaphylaxis in the setting of spinal anesthesia. J Clin Anesth. 2016;35:145-149. doi:10.1016/j.jclinane. 2016.07.009
Öz
Anaphylaxis is a rare but potentially life-threatening systemic hypersensitivity reaction that may occur during anesthesia (1). When it occurs under anesthesia, diagnosis and treatment can be delayed. The most common causes include neuromuscular blocking agents, antibiotics, latex, and, rarely, proton pump
inhibitors (2). We report an anaphylactic reaction that developed after intravenous pantoprazole administration under spinal anesthesia.
Anahtar Kelimeler
Anaphylaxis Pantoprazole Proton pump inhibitor Spinal anesthesia Tryptase
Kaynakça
- Harper NJN, Cook TM, Garcez T, Farmer L, Floss K, Marinho S, Torevell H, Warner A, Ferguson K, Hitchman J, Egner W, Kemp H, Thomas M, Lucas DN, Nasser S, Karanam S, Kong KL, Farooque S, Bellamy M, McGuire N. Anaesthesia, surgery, and life-threatening allergic reactions: Epidemiology and clinical features of perioperative anaphylaxis in the 6th National Audit Project (NAP6). Br J Anaesth. 2018;121(1):159-171. doi:10.1016/j.bja.2018.04.014
- Low AE, McEwan JC, Karanam S, North J, Kong KL. Anaesthesia-associated hypersensitivity reactions: Seven years’ data from a British bi-specialty clinic. Anaesthesia. 2016;71(1):76-84. doi:10.1111/anae.13273
- Dewachter P, Savic L. Perioperative anaphylaxis: pathophysiology, clinical presentation and management. BJA Educ. 2019;19(10):313-320. doi:10.1016/j.bjae.2019.06.00
- Telaku S, Veliu A, Zenelaj Q, Telaku M, Fejza H, Alidema F. Anaphylaxis caused by taking pantoprazole: Case series. Eur J Case Rep Intern Med. 2023;10(9):004017. doi:10.12890/2023_004017. PMID: 37680781; PMCID: PMC10482135.
- Osman BM, Maga JM, Baquero SM. Case report: Management of differential diagnosis and treatment of severe anaphylaxis in the setting of spinal anesthesia. J Clin Anesth. 2016;35:145-149. doi:10.1016/j.jclinane. 2016.07.009
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Anesteziyoloji |
| Bölüm | Kısa Bildiri |
| Yazarlar | |
| Gönderilme Tarihi | 10 Ekim 2025 |
| Kabul Tarihi | 11 Kasım 2025 |
| Yayımlanma Tarihi | 29 Aralık 2025 |
| Yayımlandığı Sayı | Yıl 2025 Cilt: 4 Sayı: S2 |