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SUGAMMADEKS UYGULAMASI ARDINDAN GELİŞEN ANAFİLAKTİK ŞOK VE KARDİYAK ARREST

Yıl 2025, Cilt: 4 Sayı: S2, 13 - 14, 29.12.2025

Öz

Sugammadeks, aminosteroid yapılı nöromüsküler blokörlerin selektif antagonizasyonu amacıyla kullanılan bir ajandır. Genelde neostigmine göre daha güvenli kabul edilmesine rağmen (1), perioperatif dönemde ani hipotansiyon, bradikardi, dolaşım kollapsı ve hatta kardiyak arrest ile seyreden aşırı duyarlılık reaksiyonları bildirilmiştir (2–4). Bu olgu sunumunda, operasyon bitiminde sugammadeks uygulanmasını takiben dakikalar içinde gelişen hemodinamik kollaps, kardiyak arrest ve başarılı resüsitasyon sürecini sunmayı amaçladık.

Kaynakça

  • Carron M, Zarantonello F, Tellaroli P, Ori C. Efficacy and safety of sugammadex compared to neostigmine for reversal of neuromuscular blockade: a meta-analysis of randomized controlled trials. J Clin Anesth. 2016 Dec;35:1–12.
  • Teng IC, Chang YJ, Lin YT, Chu CC, Chen JY, Wu ZF. Sugammadex induced bradycardia and hypotension: A case report and literature review. Medicine (Baltimore). 2021 July 30;100(30):e26796.
  • Weerasuriya S, Seddon D, Salota V. Asystolic cardiac arrest secondary to sugammadex administration in a young patient. Anaesthesiol Intensive Ther. 2024 July 23;56(2):160–3.
  • Pereira AV, Oliveira RR, Esteves C, Coutinho MA. Cardiac arrest following sugammadex administration. Anaesth Rep. 2023 Jan;11(1):e12233.
  • Arslan B, Sahin T, Ozdogan H. Sugammadex and anaphylaxis: An analysis of 33 published cases. J Anaesthesiol Clin Pharmacol. 2021 Apr;37(2):153–9.
  • Abdelrahim MT, Kassels AC, Stark CW, Roberts CJ, Vogt JA, Ebert TJ. A Case Report of Acute Onset and Rapid Resolution of Atrioventricular Block After Sugammadex: Is the Autonomic System Involved? AA Pract. 2023 May 5;17(5):e01683.
  • Boo KY, Park SH, Park SK, Na C, Kim HJ. Cardiac arrest due to coronary vasospasm after sugammadex administration -a case report-. Korean J Anesthesiol. 2023 Feb 1;76(1):72–6.
  • Yoshida T, Sumi C, Uba T, Miyata H, Umegaki T, Kamibayashi T. A rare case of atropine-resistant bradycardia following sugammadex administration. JA Clin Rep. 2020 Dec;6(1):18.
  • Kadiyala M, Gedulig T, Banik RK. Adverse Effects of Sugammadex on the Cardiovascular System. Cureus. 2023 Feb 7;

ANAPHYLACTIC SHOCK AND CARDIAC ARREST FOLLOWING SUGAMMADEX ADMINISTRATION

Yıl 2025, Cilt: 4 Sayı: S2, 13 - 14, 29.12.2025

Öz

Sugammadex selectively antagonizes aminosteroid neuromuscular blockers. Although regarded as safer than neostigmine (1), perioperative hypersensitivity has been reported, presenting with sudden hypotension, bradycardia, circulatory collapse, and cardiac arrest (2–4). We present hemodynamic collapse, cardiac arrest, and successful resuscitation occurring within minutes following sugammadex administration at the end of the operation.

Kaynakça

  • Carron M, Zarantonello F, Tellaroli P, Ori C. Efficacy and safety of sugammadex compared to neostigmine for reversal of neuromuscular blockade: a meta-analysis of randomized controlled trials. J Clin Anesth. 2016 Dec;35:1–12.
  • Teng IC, Chang YJ, Lin YT, Chu CC, Chen JY, Wu ZF. Sugammadex induced bradycardia and hypotension: A case report and literature review. Medicine (Baltimore). 2021 July 30;100(30):e26796.
  • Weerasuriya S, Seddon D, Salota V. Asystolic cardiac arrest secondary to sugammadex administration in a young patient. Anaesthesiol Intensive Ther. 2024 July 23;56(2):160–3.
  • Pereira AV, Oliveira RR, Esteves C, Coutinho MA. Cardiac arrest following sugammadex administration. Anaesth Rep. 2023 Jan;11(1):e12233.
  • Arslan B, Sahin T, Ozdogan H. Sugammadex and anaphylaxis: An analysis of 33 published cases. J Anaesthesiol Clin Pharmacol. 2021 Apr;37(2):153–9.
  • Abdelrahim MT, Kassels AC, Stark CW, Roberts CJ, Vogt JA, Ebert TJ. A Case Report of Acute Onset and Rapid Resolution of Atrioventricular Block After Sugammadex: Is the Autonomic System Involved? AA Pract. 2023 May 5;17(5):e01683.
  • Boo KY, Park SH, Park SK, Na C, Kim HJ. Cardiac arrest due to coronary vasospasm after sugammadex administration -a case report-. Korean J Anesthesiol. 2023 Feb 1;76(1):72–6.
  • Yoshida T, Sumi C, Uba T, Miyata H, Umegaki T, Kamibayashi T. A rare case of atropine-resistant bradycardia following sugammadex administration. JA Clin Rep. 2020 Dec;6(1):18.
  • Kadiyala M, Gedulig T, Banik RK. Adverse Effects of Sugammadex on the Cardiovascular System. Cureus. 2023 Feb 7;
Toplam 9 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Anesteziyoloji
Bölüm Kısa Bildiri
Yazarlar

Sinem Özçelik Bu kişi benim 0009-0007-6606-5455

Helin Özler 0009-0008-0035-0373

Onur Küçük 0000-0001-5534-7579

Gönderilme Tarihi 1 Kasım 2025
Kabul Tarihi 8 Kasım 2025
Yayımlanma Tarihi 29 Aralık 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 4 Sayı: S2

Kaynak Göster

AMA Özçelik S, Özler H, Küçük O. SUGAMMADEKS UYGULAMASI ARDINDAN GELİŞEN ANAFİLAKTİK ŞOK VE KARDİYAK ARREST. TJR. Aralık 2025;4(S2):13-14.