Klinik Araştırma
BibTex RIS Kaynak Göster

Systemic Immunological Changes in Seborrheic Blepharitis

Yıl 2008, Cilt: 2 Sayı: 1, 227 - 230, 23.03.2008

Öz

The aim of the study is to evaluate the systemic immunological changes in seborrheic blepharitis. Twenty seven patients with seborrheic blepharitis and 24 patients without blepharitis were evaluated in terms of Schirmer and fluorescein break -up time (FBUT) scores, serum levels of CRP, Ig M and Ig E. The tear function tests of the groups were significantly different. Schirmer scores of the blepharitis group and of the control group were 15.75±5.20 mm and 18.15±3.02 mm respectively (p value: 0.006). FBUT score of the blepharitis group was 5.02+1.69 seconds and that of the control group was 9.90+2.25 seconds (p: 0.000). Serum levels of CRP was 4.73±2.36 mg/L in the blepharitis group and it was 3.13±1.32 mg/L in the control group. This was a statistically significant difference (p: 0.005). Ig M levels were higher in blepharitis group (1.31±0.62 g/L) than in the control group (0.95±0.27 g/L) This was statistically significant too (p:0.01). Serum levels of Ig E were not significantly different between the two groups. Seborrheic blepharitis may be associated with subclinical systemic immunologic problems. Detailed immunological tests may be helpful in the evaluation of this pathology.

Kaynakça

  • 1. Mothers WD, Shields WJ, Sachdev MS, Petroll WM, Jester JW. Meibomian gland dysfunction in chronic blepharitis. Cornea 1991; 10: 277-85.
  • 2. Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res 2004; 78:409-416.
  • 3. Driver PJ, Lemp MA. Meibomian gland dysfunction. Survey Ophthalmol. 1996; 40:343-67.
  • 4. McCulley JP, Shine WE. Meibomian secretions in chronic blepharitis. Adv Exp Med Biol. 1998; 438: 319-326.
  • 5. Zengin N, Tol H, Gündüz K, Okudan S, Balevi S, Endoğru H. Meibomian gland dysfunction and tear film abnormalities in rosacea. Cornea 1995; 14:144-146.
  • 6. Shine WE, Silvany R, Me Culley JP. Relation of cholesterol stimulated Staphylococcus aureus growth to chronic blepharitis. Invest Ophthalmol Vis Sci. 1993; 34: 2291-2296.
  • 7. McDermott AM. Defensins and other antimicrobial peptides at the ocular surface. Ocul Surf. 2004;2:229-47.
  • 8. Du Clos TW. Function of C-reactive protein. Annals Med 2000;32: 274-278.
  • 9. Abbas AK, Lichtman AH. Effector Mechanisms of Immune Responses. In: Abbas AK, Lichtman AH, editors. Cellular and Molecular Immunology. Philadelphia; Elsevier Saunders 2005; 294.
  • 10. Abbas AK, Lichtman AH. Effector Mechanisms of Immune Responses. In: Abbas AK, Lichtman AH, editors. Cellular and Molecular Immunology. Philadelphia; Elsevier Saunders 2005; 204-205.
  • 11. Schopf L, Luccioli S, Bundoc V, Justice P, Chan CC, Wetzel BJ, Norris HH, Urban JF Jr, Keane-Myers A. Differential modulation of allergic eye disease by chronic and acute as-caris infection. Invest Ophthalmol Vis Sci. 2005;46:2772-80.
  • 12. Kıratlı HK, Akar Y. Multiple recurrent hordeola associated with selective IgM deficiency.J AAPOS. 2001; 5: 60-1.
  • 13. Wheeland RG, Thurmond RD, Gilmore WA, Blackstock R. Chronic blepharitis and pyoderma of the scalp: an immune deficiency state in a father and son with hypercupremia and decreased intracellular killing. Pediatr Dermatol 1983;1:134-42.
  • 14. Seal DV, McGill JI, Jacobs P, Liakos GM, Goulding NJ. Microbial and immunological investigations of chronic non-ulcerative blepharitis and meibomianitis. Br J Ophthalmol 1985; 69:604-11.
  • 15. Bjerrum KB. Test and symptoms in keratoconjunctivitis sicca and their correlation. Acta Ophthalmol Scand 1996; 74:436-41.
  • 16. Hecht KA, Straus H, Denny M. Normal physiology of the ocular surface. In: Hecht KA, Straus H, Denny M, Taylor F, Garrett M, eds. External Disease and Cornea. American Academy of Ophthalmology, San Francisco, 2001. p.56-7.
  • 17. Mackie I A, Seal DV. Confirmatory tests for the dry eye of Sjogren's syndrome. Scand J Rheumatol Suppl. 1986;61:220-3.
  • 18. Guss RB, McCulley JP. Abnormal immune responses in the ocular presentation of Wiskott-Aldrich syndrome. Ann Ophthalmol 1982; 14:1058-60.

Seboreik Blefaritte İmmünolojik Tablo

Yıl 2008, Cilt: 2 Sayı: 1, 227 - 230, 23.03.2008

Öz

Çalışmamızda Seboreik blefaritli olgularda sistemik immünolojik enflamatuar değişikliklerin araştırılması planlandı. Seboreik blefariti olan 27 hasta ile blefarit şikayet ve bulguları olmayan 24 kontrol vakasının Schirmer testi değerleri, flöresein kırılma zamanı (FKZ), serum kantitatif C reaktif protein (CRP), Ig M ve Ig E düzeyleri değerlendirildi. Göz yaşı testlerinden Schirmer değerleri; blefarit grubunda ortalama 15.75±5.20 mm, kontrol grubunda 18.15+3.02 mm olarak ölçülmüştür. FKZ ise blefarit grubunda 5.02+1.69 saniye; kontrol grubunda 9.90±2.25 saniye olarak saptanmış olup iki grup arasından göz yaşı testleri açısından anlamlı bir fark saptanmıştır (Schirmer için p: 0.006, FKZ için p: 0.000). CRP düzeyleri; blefarit grubunda ortalama 4.73±2.36 mg/L ve kontrol grubunda 3.13±1.32 mg/L’dir ve aradaki fark istatistiksel olarak anlamlı bulunmuştur (p: 0.005). Ig M düzeyleri, blefarit grubunda 1.31+0.62 g/L, kontrol grubunda 9510.27 g/L olup, aradaki fark yine istatistiksel olarak anlamlı saptanmıştır (p: 0.01). Ig E düzeyleri açısından ise iki grup arasında anlamlı bir fark bulunmamıştır. Seboreik blefarit hastalarında sistemik enflamasyona bağlı olarak immünolojik tabloda değişiklikler görülebilir. Bu konuda daha fazla immünolojik göstergenin incelenmesi gerektiği kanaatindeyiz.

Kaynakça

  • 1. Mothers WD, Shields WJ, Sachdev MS, Petroll WM, Jester JW. Meibomian gland dysfunction in chronic blepharitis. Cornea 1991; 10: 277-85.
  • 2. Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res 2004; 78:409-416.
  • 3. Driver PJ, Lemp MA. Meibomian gland dysfunction. Survey Ophthalmol. 1996; 40:343-67.
  • 4. McCulley JP, Shine WE. Meibomian secretions in chronic blepharitis. Adv Exp Med Biol. 1998; 438: 319-326.
  • 5. Zengin N, Tol H, Gündüz K, Okudan S, Balevi S, Endoğru H. Meibomian gland dysfunction and tear film abnormalities in rosacea. Cornea 1995; 14:144-146.
  • 6. Shine WE, Silvany R, Me Culley JP. Relation of cholesterol stimulated Staphylococcus aureus growth to chronic blepharitis. Invest Ophthalmol Vis Sci. 1993; 34: 2291-2296.
  • 7. McDermott AM. Defensins and other antimicrobial peptides at the ocular surface. Ocul Surf. 2004;2:229-47.
  • 8. Du Clos TW. Function of C-reactive protein. Annals Med 2000;32: 274-278.
  • 9. Abbas AK, Lichtman AH. Effector Mechanisms of Immune Responses. In: Abbas AK, Lichtman AH, editors. Cellular and Molecular Immunology. Philadelphia; Elsevier Saunders 2005; 294.
  • 10. Abbas AK, Lichtman AH. Effector Mechanisms of Immune Responses. In: Abbas AK, Lichtman AH, editors. Cellular and Molecular Immunology. Philadelphia; Elsevier Saunders 2005; 204-205.
  • 11. Schopf L, Luccioli S, Bundoc V, Justice P, Chan CC, Wetzel BJ, Norris HH, Urban JF Jr, Keane-Myers A. Differential modulation of allergic eye disease by chronic and acute as-caris infection. Invest Ophthalmol Vis Sci. 2005;46:2772-80.
  • 12. Kıratlı HK, Akar Y. Multiple recurrent hordeola associated with selective IgM deficiency.J AAPOS. 2001; 5: 60-1.
  • 13. Wheeland RG, Thurmond RD, Gilmore WA, Blackstock R. Chronic blepharitis and pyoderma of the scalp: an immune deficiency state in a father and son with hypercupremia and decreased intracellular killing. Pediatr Dermatol 1983;1:134-42.
  • 14. Seal DV, McGill JI, Jacobs P, Liakos GM, Goulding NJ. Microbial and immunological investigations of chronic non-ulcerative blepharitis and meibomianitis. Br J Ophthalmol 1985; 69:604-11.
  • 15. Bjerrum KB. Test and symptoms in keratoconjunctivitis sicca and their correlation. Acta Ophthalmol Scand 1996; 74:436-41.
  • 16. Hecht KA, Straus H, Denny M. Normal physiology of the ocular surface. In: Hecht KA, Straus H, Denny M, Taylor F, Garrett M, eds. External Disease and Cornea. American Academy of Ophthalmology, San Francisco, 2001. p.56-7.
  • 17. Mackie I A, Seal DV. Confirmatory tests for the dry eye of Sjogren's syndrome. Scand J Rheumatol Suppl. 1986;61:220-3.
  • 18. Guss RB, McCulley JP. Abnormal immune responses in the ocular presentation of Wiskott-Aldrich syndrome. Ann Ophthalmol 1982; 14:1058-60.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Araştırma Makalesi
Yazarlar

Fatma Yulek

Yayımlanma Tarihi 23 Mart 2008
Yayımlandığı Sayı Yıl 2008 Cilt: 2 Sayı: 1

Kaynak Göster

APA Yulek, F. (2008). Seboreik Blefaritte İmmünolojik Tablo. Türk Tıp Dergisi, 2(1), 227-230.

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