RESISTANCE RATES OF MYCOBACTERIUM TUBERCULOSIS COMPLEX ISOLATES OBTAINED FROM CLINICAL SAMPLES TO MAJOR ANTITUBERCULOUS DRUGS: A STUDY IN EDIRNE, TURKEY

Yıl 2018, Cilt: 5 Sayı: 2, 28 - 31, 01.06.2018

Ozan Öner , İnan Erdem Özdemir Kubilay Elmacı , Canan Eryıldız

Öz

Aims: The aim of this study is to reveal the rates of the Mycobacterium tuberculosis complex resistance to major antituberculous drugs (streptomycin, isoniazid, rifampicin, ethambutol) by the evaluation of the specimens that are sent to Trakya University Hospital Microbiology Laboratory.

Methods:In this study, laboratory data of the cases that were pre-diagnosed with tuberculosis between 11/02/2016 and 31/12/2017 were scanned retrospectively. To compare the annual data descriptive statistics as arithmetic mean, numbers and percentages were used.

Results: Out of 4752 samples, 133 (2.79%) were culture positive. 120 isolates were identified as Mycobacterium tuberculosis complex, while other 13 were defined as Mycobacterium other than tuberculosis. Antimycobacterial susceptibility tests showed that 9 (7.5%) isolates were resistant to streptomycin, 10 (8.33%) isolates to isoniazid, 4 (3.33%) isolates to rifampicin, 4 (3.33) isolates to ethambutol. 5 (4.16%) isolates were multidrug resistant.

Conclusion: Antituberculous drug resistance is still a threat for an effective treatment of tuberculosis and streptomycin resistance has increased. However, it is also pointed out that presence of Mycobacterium other than tuberculosis in isolates has increased. 

Anahtar Kelimeler

Drug resistance, tuberculosis, streptomycin

Kaynakça

• 1. Bañuls AL, Sanou A, Anh NT et al. Mycobacterium tuberculosis: ecology and evolution of a human bacterium. Journal of Medical Microbiology 2015;64(11):1261-9.
• 2. Murray PR. Mikobakteri. In: Başustaoğlu AC, Yapar M, Tanyüksel M, editors. Tıbbi Mikrobiyoloji. Philadelphia: Mosby; 2014.p.277-90.
• 3. Akdağ R. Tüberküloz tanı ve tedavi rehberi. Ankara Türkiye Cumhuriyeti Sağlık Bakanlığı: 2011. 4. Menzies HJ, Moalosi G, Anisimova V et al. Increase in anti-tuberculosis drug resistance in Botswana: results from the fourth National Drug Resistance Survey. Int J Tuberc Lung Dis 2014;18(9):1026-33.
• 5. Mitchison DA. How drug resistance emerges as a result of poor compliance during short course chemotherapy for tuberculosis. Int J Tuberc Lung Dis 1998; 2:10–5.
• 6. Matteelli A, Migliori GB, Cirillo D et al. Multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis: epidemiology and control. Expert Rev Anti Infect Ther 2007;5:857–71.
• 7. Durmaz R. Mycobacterium tuberculosisde direnç sorunu. ANKEM Derg 2005;19(2):107-10.
• 8. Perinçek G, Tabakoğlu E, Otkun M et al. The change of antituberculosis drug resistance rate in Edirne region in 1996 and 2006. Solunum 2010;12(3):129–33.
• 9. Tansel Ö, Kuluoğlu F, Akata F et al. Resistance of Mycobacterium tuberculosis isolates to antituberculous agents: results of the last two years in Trakya University Hospital. Turkish Journal of Infection 2003;17(1):23-6.
• 10. Baylan O. Extensively drug resistant and extremely drug resistant tuberculosis forms after multi-drug resistant tuberculosis: new faces of the old disease. Mikrobiyol Bul 2011;45(1):181-95.
• 11. World Health Organization. Global tuberculosis report. Available from URL: http://apps.who.int/iris/bitstream/10665/250441/1/9789241565394-eng. pdf?ua=1&ua=1 (December 2016).
• 12. World Health Organization. The end TB strategy. Available from URL: http://www.who.int/tb/strategy/End_TB_Strategy.pdf?ua=1 (04/06/2018).
• 13. Perinçek G, Tabakoğlu E, Otkun M et al. Mycobacterium tuberculosis üremesi saptanan akciğer tüberkülozlu hastaların antitüberküloz ilaçlara direnç oranları. Tur Toraks Der 2011;12:111-3.
• 14. Sayğan MB, Ocak F, Cesur S et al. Susceptibilities of Mycobacterium tuberculosis strains collected from regional tuberculosis laboratories to major antituberculous drugs. Mikrobiyol Bul 2007;41:403-9. 15. Baylan O, Kısa BÖ, Albay A et al. Mikobakteriyoloji laboratuarımızda 2002 yılında tüberküloz olgularından izole edilen Mycobacterium tuberculosis kompleks (MTC) suşları ve antitüberküloz ilaç duyarlılık sonuçları. Gülhane Tıp Dergisi 2003;45(3):256-62.
• 16. Khalid FA, Hamid ZA, Mukhtar MM. Tuberculosis drug resistance isolates from pulmonary tuberculosis patients, Kassala State, Sudan. Int J Mycobacteriol 2015;4(1):44-7.
• 17. Tavanaee Sani A, Shakiba A, Salehi M et al. Epidemiological characterization of drug resistance among Mycobacterium tuberculosis isolated from patients in northeast of Iran during 2012-2013. Biomed Res Int 2015;2015:747085.
• 18. Baylan O, Albay A, Kısa Ö et al. Detection of primary drug resistance rates of Mycobacterium tuberculosis complex strains isolated between 2002-2003 years and comparison with the data of 1998-2001 period. Mikrobiyol Bul 2005;39:153-60.
• 19. Bozdağ İ, Coşar AD, Özer A. Klinik örneklerden izole edilen Mycobacterium tuberculosis kompleks suşlarının antibiyotiklere direnç oranları. Tıp Araştırmaları Dergisi 2015;13(1):6-10.
• 20. Sezen F, Albayrak N, Özkara Ş et al. The first step for national tuberculosis laboratory surveillance; Ankara, 2011. Mikrobiyol Bul 2015;49(2):143-55.