Pregnancy and Postpartum Period in Multiple Sclerosis

Abstract

Objectives: Multiple sclerosis (MS) is a chronic and immune-mediated inflammatory disease of the central nervous system. The disease particularly affects women of childbearing age. In this study we report the pregnancy and postpartum period in multiple sclerosis patients who were followed up in our clinic. Method: Retrospective data from MS patients who became pregnant at any time of disease were collected in Inonu University Turgut Ozal Medical Center, Department of Neurology Multiple sclerosis clinic. Results: Data on 110 women MS patients files were examined. There were 25 MS patients who became pregnant. 17 of 25 patients were prediagnosis group, 8 patients were after diagnosis group. Relapse rate in pregnancy was very low in our patients. There was no complications in newborns. The patients who experienced relapse usually had this relapse in 1-9 months after delivery. Conclusions: Our patients had lower relapse rate (4%) in pregnancy. In postpartum period, the relapse rate increases especially during the first three months after delivery. Key words: Multiple Sclerosis; Pregnancy; Postpartum Period.

Keywords

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Multipl Sklerozda Gebelik ve Postpartum Dönem

Öz

Amaç: Multipl skleroz (MS) merkezi sinir sisteminin kronik ve immun aracılı demiyelinizan bir hastalığıdır. Hastalık özellikle doğurganlık çağındaki kadınları etkiler. Biz bu yazımızda kendi kliniğimizde takipli MS hastalarının gebelik ve postpartum dönemdeki ataklarını inceledik. Metod: İnönü Üniversitesi Turgut Özal Tıp Merkezi Nöroloji Anabilim dalı MS polikliniğinde takipli ve hastalığın herhangi bir evresinde gebelik yaşamış MS hastalarının dosyaları retrospektif olarak incelendi. Bulgular: 110 kadın hastanın dosya incelemesi yapıldı. 25 hastanın MS tanısı almadan kısa süre önce ya da MS tanısı aldıktan sonra gebe kaldığı saptandı. 25 hastanın 17'si MS tanısından önce (tanı öncesi grup), 8'i ise MS tanısı (tanı sonrası grup) konulduktan sonra gebe kalmıştı. Gebelikte relaps oranı oldukça düşük (%4) olarak saptandı. Yeni doğanlarda herhangi bir komplikasyon izlenmedi. Postpartum dönemde atak geçiren hastaların bu atakları genellikle doğumdan sonraki ilk 1-9 ayda yaşadığı görüldü. Sonuç: Bizim hastalarımızda gebelikte atak oranı oldukça düşüktü. Postpartum dönemde atak riski özellikle ilk üç ayda artmaktadır. Anahtar Sözcükler: Multipl Skleroz; Gebelik; Postpartum Dönem.

Anahtar Kelimeler

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Kaynakça

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