Management of Adult Immune Thrombocytopenia: Review Article

Abstract

Immune thrombocytopenia (ITP) is an acquired autoimmune disorder defined by isolated thrombocytopenia and the exclusion of other causes of thrombocytopenia.Although the underlying pathophysiology of ITP has been known for more than five decades, therapy has remained empirical. ITP guidelines were published by the American Society of Hematology 15 years ago (updated in 2011) and the British Committee for Standards in Hematology 8 years ago. The primary treatment goal is to prevent severe bleeding rather than achieve normal platelet counts. Nowadays, new therapeutic agents have changed strategies for ITP treatment. In this review,we discuss criteria for treatment, the role of splenectomy and other treatment options along with their side effects, and the treatment of ITP during pregnancy. Key words: Primary; Immune; Thrombocytopenia; Treatment; ITP.

Keywords

• Primary; Immune; Thrombocytopenia; Treatment; ITP.

Erişkin İmmun Trombositopeni ve Tedavisi: Derleme

Öz

İmmün trombositopeni (İTP) diğer trombositopeni yapan nedenlerin olmaması ve izole trombositopeni ile seyreden edinilmiş otoimmün hastalıktır. İTP'nın patofizyolojisi 50 yıldan daha uzun süredir bilinmesine rağmen tedavi empirik olarak kalmıştır. İTP kılavuzu 15 yıl önce Amerikan Hematoloji Derneği(2011 de güncellenmiştir) ve 8 yıl önce de Hematoloji Standartları İngiliz Komitesi tarafından yayınlanmıştır. Tedavinin başlıca amacı normal platelet sayısına ulaşıncaya kadar ciddi kanamayı engellemektir. Günümüzde İTP'de yeni ilaçlarla tedavi stratejileri değişti. Bu derlemede erişkin İTP'de tedavi kriterlerini, tedavi yaklaşımlarını, splenektominin rolünü, yan etkileri ile birlikte diğer tedavi seçeneklerini ve gebelikteki İTP'nın tedavisini tartıştık. Anahtar kelimeler: Primer; Immün; Trombositopeni; Tedavi; İTP.

Anahtar Kelimeler

• Primer; Immün; Trombositopeni; Tedavi; İTP.

Kaynakça

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49. Corresponding Author: Mehmet Ali ERKURT
50. Inonu University Faculty of Medicine,
51. Department of Hematology, TR-44069 Malatya
52. Phone: [phone], ext. 4203
53. celluler phone :[phone]
54. Fax: [phone]
55. e-mail: [e-mail]