Histopathologic Subtypes of Surgically Resected Papillary Thyroid Carcinomas in Malatya Region+

Abstract

Abstract: Retrospective analysis of histologic subtypes of papillary thyroid carcinoma (PTC). Material and Method: Histopathology reports at the Department of Pathology, Inönü University, Medical School Malatya, Turkey revealed 33 papillary thyroid carcinoma (PTC) cases in a nine year period. Results: The demographic findings (23 females, 10 males with an average age of 45) were similar to previous reports but the distribution of the PTC subtypes showed some variation. The number and percentage of the PTC subtypes were as following: encapsulated 8 (24%), tall cell 7(21%), follicular 7 (21%), macrofollicular 5 (15%), oncocytic 3 (9%) and micro-carcinoma 3 (9%). Though the total number of the cases is not suitable for a statistical analysis incidence of the aggressive variant i.e. tall cell subtype is remarkable when compared to other series published. Lymph node metastasis was detected predominantly in the oncocytic (66.7%) and tall cell (%57.1%) subtypes. Conclusion: Tall cell and oncocytic PTC must be distinguished in the surgical pathology reports precisely for clinical evaluation due to high frequency of lymph node metastasis. Key words: Thyroid Cancer, Histopathology, Papillary Thyroid Carcinoma

Keywords

• Thyroid Cancer, Histopathology, Papillary Thyroid Carcinoma

Malatya Bölgesinde Cerrahi Uygulanmış Tiroid Papiller Kanserlerinin Histopatolojik Alt Grupları

Öz

Amaç: Papiller tiroid kanseri (PTK) alt gruplarının retrospektif analizi. Gereç ve Yöntem: Malatya İnönü Üniversitesi Tıp Fakültesi, Patoloji Laboratuarı arşivinde dokuz yıllık zaman dilimi içinde cerrahi girişimle tiroidektomi uygulanmış 33 adet PTK olgusu değerlendirildi. Bulgular: Demografik verilerin (23 kadın, 10 erkek, ortalama 45 yaş ) daha önce bildirilmiş özelliklere uyduğu görüldüyse de PTK histopatolojik alt gruplarında farklılıklar tespit edildi. PTK alt gruplarında sıklık sırasıyla, kapsüllü 8 (%24), yüksek hücreli 7 (%21), folliküler 7 (%21), makrofolliküler 5 (%15), onkositik 3 (%9) ve mikrokarsinom 3 (%9) izlendi. Toplam hasta sayısı istatiksel analize olanak vermese de kötü gidişli kabul edilen yüksek hücreli alt grup yayınlanmış serilerdekilerden fazladır. Lenf düğümü metastazları en fazla sırasıyla onkositik (%66.7) ve yüksek hücreli (%57.1) gruplarda izlendi. Sonuç: PTK içinde sık lenf düğümü yayılımı nedeniyle onkositik ve yüksek hücreli alt grupların patoloji raporlarında ayırd edilerek belirtilmesi ve klinik değerlendirmenin gerekliliği ortaya çıkmaktadır. Anahtar kelimeler: Tiroid Kanseri, Histopatoloji, Papiller Tiroid Kanseri

Anahtar Kelimeler

• Tiroid Kanseri, Histopatoloji, Papiller Tiroid Kanseri

Kaynakça

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15. Inönü University Medical School, Department of Pathology, MALATYA, 44280
16. Telephone: [phone]/5210
17. e-mail: [e-mail]