Homocysteın As A Rısk Factor In Acute Ischemic and Acute Hemorrhagic Cerebral Stroke

Abstract

Objective : Elevated level of serum homocystein is accepted as a risk factor which is indefinite, changeable and independent for ischemic strokes. However such a relationship in the hemorrhagic strokes has not been vastly discussed. The goal of this study is to investigate whether the elevated serum homocystein level, as a risk factor for the acute ischemic and acute hemorrhagic strokes, shows a meaningful difference or not. Material and Methods : 32 patients who were hospitalized with diagnosis of acute ischemic stroke and 32 patients who were hospitalized with diagnosis of acute hemorrhagic stroke in the Neurology Department of Taksim Training and Research Hospital between February 2005 and June 2006 were included in the study group. None of these patients belonging to the two groups defined a stroke history. The results were evaluated by using the following statistical methods; Mann Whitney U, One-way Variance Analysis, Q square test, Pearson Correlation Analysis, Dunn's Multiple Comparison Test. Results : The average of serum homocystein level in ischemic stroke group and in hemorrhagic stroke group were 15,9 +/- 5.4 μmol/l, 15,8 +/- 6.1 μmol/l respectively (normal adult serum homocystein level is 5-14 μmol/l). No meaningful difference with respect to homocystein level found between two groups. (P>0.05) Conclusion : This study supported that there is no meaningful difference with respect to the elevation of homocystein level between the studied two-groups. Key words: Homocysteine, Acute ischemic cerebrovascular disease, Acute hemorrhagic cerebrovascular disease

Keywords

• Homocysteine, Acute ischemic cerebrovascular disease, Acute hemorrhagic cerebrovascular disease

Akut İskemik ve Akut Hemorajik İnmede Risk Faktörü Olarak Homosistein

Öz

Amaç : Serum yüksek homosistein düzeyi, iskemik inmeler için bağımsız, değiştirilebilen, kesinleşmemiş bir risk faktörü olarak kabul edilmektedir. Hemorajik inmelerde ise, böyle bir ilişki çok tartışılmamıştır. Bu çalışmanın amacı, serum yüksek homosistein düzeyinin, akut iskemik inme ve akut hemorajik inmeli hastalarda risk faktörü olarak, anlamlı bir fark gösterip göstermeyeceğini değerlendirebilmekti. Gereç ve Yöntem: Taksim Eğitim ve Araştırma Hastanesi Nöroloji Kliniğine Şubat 2005 –Haziran 2006 tarihleri arasında yatırılan, daha önce herhangi bir inme geçirmemiş, akut hemorajik serebrovasküler hastalık tanısı alan 32 olgu ve yine akut iskemik serebrovasküler hastalık tanısı alan 32 olgu değerlendirildi. İstatistiksel olarak sonuçlar; Mann-Whitney-U testi, tek yönlü varyans analizi, ki kare testi, Pearson korelasyon analizi testi, Dunn's çoklu karşılaştırma testi aracılığı ile değerlendirildi. Sonuçlar : İskemik serebrovasküler hastalık grubunda, serum homosistein düzeyi ort: 15.9± 5.4 mmol /L, hemorajik grupta bu düzey ort:15.8± 6.1mmol /L olarak elde edildi. (normal erişkin serum homosistein düzeyi: 5-14 mmol / L). İskemik serebrovasküler hastalık grubundaki serum homosistein düzeyi ile hemorajik serebrovasküler hastalık grubundaki serum homosistein düzeyi arasında anlamlı fark bulunmadı( p>0.05). Yorum : Sonuç olarak yaptığımız çalışma, risk faktörü olarak yüksek serum homosistein düzeylerinin akut iskemik ve akut hemorajik serebrovasküler hastalıklar arasında anlamlı bir fark göstermediğini desteklemektedir. Anahtar kelimeler: Homosistein, Akut iskemik serebrovasküler hastalık, Akut hemorajik serebrovasküler hastalık

Anahtar Kelimeler

• Homosistein, Akut iskemik serebrovasküler hastalık, Akut hemorajik serebrovasküler hastalık

Kaynakça

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