Case Report of Cogan Syndrome

Öz

Cogan syndrome is an inflammatory vascular disease with involvement of eye and ear. Cogan syndrome consists of interstitial keratitis associated with vestibuloauditory dysfunction. The disease has a predilection for large and medium sized blood vessels. Early diagnosis of Cogan syndrome is important because prompt treatment of the cochlear symptoms with systemic steroids may prevent permanent and profound deafness. A case of Cogan syndrome in chronic stage is represented in this report. Key words: Cogan syndrome, Interstitial keratitis, Audiovestibular dysfunction

Anahtar Kelimeler

• Cogan syndrome, Interstitial keratitis, Audiovestibular dysfunction

Cogan Sendromlu Bir Olgu+

Öz

Cogan sendromu göz ve kulak tutulumunun birlikte görüldüğü inflamatuar damarsal bir hastalıktır. Gözde interstisyel keratit, kulakta odyovestibüler disfonksiyon bulguları ile karakterizedir. Cogan sendromlu hastalarda büyük ve orta büyüklükteki damarları tutan vaskülit izlenebilmektedir. Cogan Sendromunda erken tanı ve sistemik kortikosteroid tedavisi göz bulgularının ilerlememesi ve kalıcı sağırlık gelişimini önlemesi açısından çok önemlidir. Bu çalışmada geç tanı alan ve kalıcı sağırlık gelişen bir olgu irdelenmiştir. Anahtar kelimeler: Cogan sendromu, İnterstisyel keratit, Odyovestibuler disfonksiyon

Anahtar Kelimeler

• Cogan sendromu, İnterstisyel keratit, Odyovestibuler disfonksiyon

Kaynakça

1. Cogan DG. Syndrome of non-syphilitic interstitial keratitis and vestibulo-auditory symptoms. Arch Ophthalmol. 1945; 33:144-9.
2. Helmchen C, Arbusow V, Jager L, Strupp M, Stocker W, Schulz P. Cogan’s syndrome: clinical significance of antibodies against the inner ear and cornea. Acta Otolaryngol 1999; 119:528-36.
3. Casoli P, Tumati B. Cogan’s syndrome: a new possible complication of antiphospholopid antibodies? Clin Rheumatol. 1995; 14:197-8.
4. Kaiser-Kupfer MI, Mittal KK, Del ValleLA, Haynes BF. The HLA antigens in Cogan’s syndrome. Am J Ophthalmol. 1978; 86:314-16.
5. Ndiaye I, Rassi S, Wiener-Vacher S. Cochleovestibular impairment in pediatric Cogan’s Syndrome. Pediatrics 2002; 109:pp.e38.
6. McDonald TJ, Vollertsen RS, Younge BR. Cogan’s syndrome: Audiovestibular involvement and prognosis in 18 patients. Laryngoscope 1985; 95:650-4.
7. Bachynski B, Wise C. Cogan’s syndrome: a treatable cause of neurosensory deafness. Can J Ophthalmol 1984; 198:145-7.
8. Allen NB, Cox CC, Cobo M, Ksslo J, Jacobs MR, Mc Callum RM, Haynes BF. Use of immunosuppressive agents in the treatment of severe ocular and vascular manifestations of Cogan’s syndrome. Am j Med 1990; 88:296-301.

9. Haynes BF, Kaiser-Kupfer MI, Mason P, Fauci AS. Cogan’s syndrome: studies in thirteen patients, long-term follow-up and a review of the literature. Medicine 1980; 59:426-41.
10. Thomas HG. Case report. Clinical and radiological features of Cogan’s syndrome- non-syphilitic interstitial keratitis, audiovestibuler symptoms and systemic manifestations. Clinical Radiology 1992; 45:418-21.
11. Ünlü K, Aksünger A, Meriç F, Avaoğlu S, Ülgen S. Cogan Sendromu: Olgu Sunumu. T Klin Oftalmoloji 1999; 8:66-9.
12. Smith EW, Roelcke V. Cogan’s syndrome. J Clin Neuro-Ophthalmol 1990; 10:261.
13. Cote DN, Molony TB, Waxman J, Parsa D. Cogan’s syndrome manifesting as sudden bilateral deafness: diagnosis and management. South Med J 1993; 86:1056-60.