Multiple Sclerosis And Psoriasis

Abstract

Natural and recombinant interferons are increasingly being used to treat patients with multiple sclerosis and various inflammatory, infectious, and neoplastic processes. Adverse reactions are usually limited to headache, fever, and myalgia, but occasional unexpected problems can be severe enough to limit use of the drug. One such problem is the exacerbation of psoriasis. In our clinic, two patients with multiple sclerosis who were receiving injections of interferon had a psoriasis attack. One of the patients had psoriasis before the interferon treatment but other patient had no such history. Key words: Multiple Sclerosis, Beta Interferon, Psoriasis.

Keywords

• Multiple Sclerosis, Beta Interferon, Psoriasis.

Multiple Skleroz ve Psoriasis

Öz

Rekombinant interferonlar Multiple Skleroz (MS) yanısıra çeşitli enflamatuar hastalıklarda, Hepatit C gibi enfeksiyonlarda ve lösemi gibi neoplasmlarda artan oranlarda kullanılmaya başlanmıştır. Yan etkileri genellikle; başağrısı, ateş ve myaljidir, ancak ender olarak ilacın kullanımını sınırlayan daha ciddi yan etkiler de bildirilmiştir. MS'lu hastalarda diğer otoimmun hastalıkların insidansı genel populasyondan çok daha yüksek orandadır. MS'da psoriasis birlikteliği az sayıda hastada bildirilmiştir. Kliniğimizde izlenen 2 MS'lu olguda beta-interferon tedavisi ile psoriasis atağı gözlendi. Olgulardan biri daha önce psoriasis tanısı almıştı. Diğer olguda özgeçmişinde psoriasis tanısı yoktu. Her iki olguda da beta interferon tedavisinin 2. haftasında döküntüler oluştu. Literatürde Psorisisin beta interferonla alevlendiğine ait bir bilgiye rastlanmadığı için olgular sunulmaya değer bulundu. Anahtar kelimeler: Multiple skleroz, Beta interferon, Psoriasis

Anahtar Kelimeler

• Multiple skleroz, Beta interferon, Psoriasis

Kaynakça

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