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Abstract

Gliomatosis cerebri is a rare diffuse involvement of the central nervous system by a malignant glioma that permeates the brain extensively without destroying the neural architecture. It involves more than two of the lobes. Oligodedroglial component can be predictive for a better prognosis. This is a report of two patients: a 33-year-old female patient and a 58-year-old male patient. A stereotactic biopsy was performed for our first patient. She was diagnosed with grade 2 astrocytoma. The second case was a grade 3 patient who was diagnosed with tumour infiltration in line with gliomatosis cerebri. Both cases underwent external beam radiotherapy at 44 Gy and 50 Gy, respectively, with a helical tomotherapy device. The patients tolerated the cure quite well and no acute complications (except for grade 1 skin reactions) were observed during the therapy. Radiotherapy volume and treatment dose are still controversial in the treatment of gliomatosis cerebri. Partial or whole brain radiotherapy can be applied

Keywords

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Gliomatozis Serebride Radyoterapinin Yeri: İki Olgu Deneyimi

Öz

Gliomatozis serebri, oldukça nadir görülen, beyinde en az iki lobu tutan, nöral yapıların korunduğu, diffüz neoplastik glial hücre proliferasyonudur. Oligodedroglial komponent varlığı prognoz açısından daha iyidir. Olgularımız 33 yaşında bayan ve 58 yaşında erkek hastadır. Birinci olgumuzda stereotaktik biyopsi yapılmış. Grade 2, astrositom olarak değerlendirilmiş. İkinci olgumuz ise biyopsi sonucu Grade 3, Gliomatozis serebri ile uyumlu tümör infiltrasyonu olarak değerlendirilmiş. Hastalarımıza Helikal Tomoterapi cihazında sırasıyla 44 Gy ve 50 Gy eksternal radyoterapi uygulandı. Hastalar tedaviyi iyi tolere etti ve tedavi süresince grade 1 cilt reaksiyonu dışında akut komplikasyon gözlenmedi. Gliomatozis serebride radyoterapi volümü, tedavi dozu tartışmalıdır. Tüm beyin veya parsiyel radyoterapi uygulanabilmektedir

Anahtar Kelimeler

• Gliomatozis Serebri, Radyoterapi, Tomoterapi

Kaynakça

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