Haploidentical Transplantation Experience in Turgut Ozal Medical Center: Case Report and a Review of Literature

Yıl 2014, Cilt: 21 Sayı: 1, 55 - 58, 01.02.2014

Ilhami Berber Mehmet Ali Erkurt Emin Kaya Mustafa Koroglu Ilknur Nizam Recep Bentli Irfan Kuku

Öz

Haploidentical hematopoietic stem-cell transplantation is an optional transplant modality for patients without a Human Leukocyte Antigens-matched donor. Still, one-third of patients who might benefit from allogeneic transplantation are able to find a Human Leukocyte Antigens-matched related donor. In need of immediate stem-cell transplantation, haploidentical donor is an important solution for many patients. Previously, haploidentical hematopoietic stem-cell transplantation was characterised by a high rejection rate, graft-versus-host disease, graft failure, and transplant-related mortality, but there have since been significant improvements in some areas. Development of new extensive T-cell depletion methods with megadose stem cell administration have overcome problems of haploidentical hematopoietic stem-cell transplantation. We presented an applied case haploidentical hematopoietic stem-cell transplantation as an experience in Turgut Ozal Medical Center. Key words: Haploidentical; Transplantation; Experience.

Anahtar Kelimeler

Haploidentical; Transplantation; Experience.

Turgut Özal Tıp Merkezindeki Haploidentik Nakil Deneyimimiz: Olgu Sunumu ve Literatür Sunumu

Öz

Haploidentik kök hücre nakli HLA uyumlu donörü olmayan hastalar için başka bir alternatif nakil modelidir. Hala, allojenik nakil gereksinimi olan hastaların ancak üçte biri HLA uyumlu vericiye sahiptir. Acil kök hücre nakli gereksiniminde haploidentik nakil bir çok hasta için önemli bir çözüm yoludur. Daha önceleri haploidentik hematopoetik kök hücre nakli yüksek oranda graft rejeksiyonu, graft versus host hastalığı, graft başarısızlığı ve nakil ile ilgili mortalite ile karakterize idi, fakat T hücre deplesyonundaki yeni gelişmeler ve mega doz kök hücre nakli yönetimi haploidentik kök hücre naklinde bazı problemlere çözüm oldu. Biz bir vakaya uygulanan Turgut Özal Tıp Merkezi' ndeki haploidentik kök hücre nakli deneyimimizi sunduk. Anahtar kelimeler: Haploidentik; Nakil; Deneyim.

Anahtar Kelimeler

Haploidentik; Nakil; Deneyim.

Kaynakça

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