BibTex RIS Kaynak Göster

The Youngest Advanced Stage Grade III Endometrial Carcinoma: A Case Report

Yıl 2011, Cilt: 18 Sayı: 4, 269 - 271, 01.08.2011

Öz

Inroduction: Endometrail cancer, typically diagnosed in the postmenopausal years, is the most common gynecologic malignancy. Young women with endometrial carcinoma are considered to have a favorable prognosis with early stage, well differentiated lesions. In this report we present young patient with advanced stage endometrial adenocarcinoma who had poor prognosis. Case Report: A 23 year old female applied to the hospital because of postabortal bleeding despite revision curettage. Endometral sampling was perfomed and grade 3 endometrail adenocarcinoma was diagnosed. Athought total abdominal hysterectomy, bilateral salphingoopherectomy, pelvic-paraaortic lymphadenectomy, infracolic omentectomy and chemotherapy were performed, recurrence of the tumor was observed one year after the surgery. The patient died because of sepsis in 24 years old. Conclusion: In this report endometrial cancer was observed in 23 years old patient with no obvious risk factor. This report is the youngest advanced stage grade 3 endometrial adenocarcinoma in the literature. Further studies to evaluate the etyopathogenic mechanisms of endometrial cancer without risk factors are needed. Key words: Advanced Stage Endometrium Cancer; Youngest.

Kaynakça

  • Jemal, A, Siegel, R, Ward, E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009; 59: 225.
  • Gallup, DG, Stock, RJ. Adenocarcinoma of the endometrium in women 40 years of age or younger. Obstet Gynecol 1984; 64: 417
  • Azim, A, Oktay, K. Letrozole for ovulation induction and fertility preservation by embryo cryopreservation in young women with endometrial carcinoma. Fertil Steril 2007; 88: 657.
  • Cirns JD, Noble AJ, Bryant ME. Carcinoma of endometrium and polycystic ovaries in a 22-year-old patient. Can Med Assoc J 1967; 96:1473-6.
  • Schmeler, KM, Soliman, PT, Sun, CC, et al. Endometrial cancer in young, normal-weight women. Gynecol Oncol 2005; 99: 388.
  • Tran BN, Connell PP, Waggoner S, et al. Characteristics and outcome of endometrial carcinoma patients age 45 years and younger. Am J Clin Oncol 2000; 23: 476-80.
  • Wang CB, Wang CJ, HuangHJ. Fertility-preserving treatment in young patients with endometrial adenocarcinoma. Cancer 2002; 94: 2192-8.
  • Peterson EP. Endometrial carcinoma in young women. A clinical profile. Obstet Gynecol 1968; 31:702-7.
  • Duska LR, Garrett A, Rueda BR. Endometrial cancer in women 40 years old or younger. Gynecol Oncol 2001; 83: 388-93.
  • Morrow CP, Bundy BN, Kurman RJ. Relationship between surgical-pathological risk factors and outcome in clinical stageI and II carcinoma of the endometrium: a Gynecologic Oncology Group Study. Gynecol Oncol 1991; 40: 55-65.
  • Berends MJ, Kleibeuker JH, de Vries EG, et al. The importance of family history in young patients with endometrial cancer. Eur J Obstet Gynecol Reprod Biol 1999; 82: 139-41.

En Genç İleri Evre Grade III Endometrium Karsinomu: Olgu Sunumu

Yıl 2011, Cilt: 18 Sayı: 4, 269 - 271, 01.08.2011

Öz

Giriş: Sıklıkla posmenapozal dönemde izlenen endometrium karsinomu en sık görülen jinekolojik malignensidir. Literatürde genç endometrial karsinom vakalarının; polikistik over hastalığı zemininde gelişen diferansiye erken evre kanserler olduğu vurgulanmaktadır. Bu makalede genç yaşta izlenen, ileri evre, kötü prognozlu endometrium karsinomu vakası sunulmuştur. Olgu Sunumu: Abortus sonrası revizyon küretaj yapılmasına rağmen vajinal kanaması devam eden 23 yaşındaki hastaya endometrial biopsi uygulanmış, patolojik inceleme sonucu Grade 3 adenokarsinom olarak gelmiştir. Yapılan operasyonda 8000 cc asit mai boşaltılmış, total abdominal histerektomi, bilateral salfingooferektomi, parsiyel omentektomi, bilateral pelvik-paraaortik lenf nodu diseksiyonu uygulanmıştır. Altı kür taksol-karboplatin kemoterapisi alan hastada operasyondan yaklaşık bir yıl sonra nüks gelişmiş, verilen kemoterapiye yanıt alınamamıştır. Hasta sepsis sebebiyle 24 yaşında kaybedilmiştir. Sonuç: Bu makalede endometriun kanseri, hiçbir risk faktörü saptanmayan 23 yaşındaki hastada izlenmiştir. Bu hasta literatürde bizim saptadığımız en genç ileri evre grade 3 endometrium kanseri olgusudur. Risk faktörleri dışında endometrium kanseri etyopatogenezinde rol alan mekanizmaları ortaya koyacak yeni yayınlara ihtiyaç vardır. Anahtar kelimeler: İleri Evre Endometrium Kanseri; En Genç.

Kaynakça

  • Jemal, A, Siegel, R, Ward, E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009; 59: 225.
  • Gallup, DG, Stock, RJ. Adenocarcinoma of the endometrium in women 40 years of age or younger. Obstet Gynecol 1984; 64: 417
  • Azim, A, Oktay, K. Letrozole for ovulation induction and fertility preservation by embryo cryopreservation in young women with endometrial carcinoma. Fertil Steril 2007; 88: 657.
  • Cirns JD, Noble AJ, Bryant ME. Carcinoma of endometrium and polycystic ovaries in a 22-year-old patient. Can Med Assoc J 1967; 96:1473-6.
  • Schmeler, KM, Soliman, PT, Sun, CC, et al. Endometrial cancer in young, normal-weight women. Gynecol Oncol 2005; 99: 388.
  • Tran BN, Connell PP, Waggoner S, et al. Characteristics and outcome of endometrial carcinoma patients age 45 years and younger. Am J Clin Oncol 2000; 23: 476-80.
  • Wang CB, Wang CJ, HuangHJ. Fertility-preserving treatment in young patients with endometrial adenocarcinoma. Cancer 2002; 94: 2192-8.
  • Peterson EP. Endometrial carcinoma in young women. A clinical profile. Obstet Gynecol 1968; 31:702-7.
  • Duska LR, Garrett A, Rueda BR. Endometrial cancer in women 40 years old or younger. Gynecol Oncol 2001; 83: 388-93.
  • Morrow CP, Bundy BN, Kurman RJ. Relationship between surgical-pathological risk factors and outcome in clinical stageI and II carcinoma of the endometrium: a Gynecologic Oncology Group Study. Gynecol Oncol 1991; 40: 55-65.
  • Berends MJ, Kleibeuker JH, de Vries EG, et al. The importance of family history in young patients with endometrial cancer. Eur J Obstet Gynecol Reprod Biol 1999; 82: 139-41.
Toplam 11 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Ebru Öztürk Bu kişi benim

Mete Gürol Uğur Bu kişi benim

Yelda Özkan Bu kişi benim

Abdullah Aydın Bu kişi benim

Özcan Balat Bu kişi benim

Yayımlanma Tarihi 1 Ağustos 2011
Yayımlandığı Sayı Yıl 2011 Cilt: 18 Sayı: 4

Kaynak Göster

APA Öztürk, E., Uğur, M. G., Özkan, Y., Aydın, A., vd. (2011). En Genç İleri Evre Grade III Endometrium Karsinomu: Olgu Sunumu. Journal of Turgut Ozal Medical Center, 18(4), 269-271.
AMA Öztürk E, Uğur MG, Özkan Y, Aydın A, Balat Ö. En Genç İleri Evre Grade III Endometrium Karsinomu: Olgu Sunumu. Turgut Özal Tıp Merk Derg. Ağustos 2011;18(4):269-271.
Chicago Öztürk, Ebru, Mete Gürol Uğur, Yelda Özkan, Abdullah Aydın, ve Özcan Balat. “En Genç İleri Evre Grade III Endometrium Karsinomu: Olgu Sunumu”. Journal of Turgut Ozal Medical Center 18, sy. 4 (Ağustos 2011): 269-71.
EndNote Öztürk E, Uğur MG, Özkan Y, Aydın A, Balat Ö (01 Ağustos 2011) En Genç İleri Evre Grade III Endometrium Karsinomu: Olgu Sunumu. Journal of Turgut Ozal Medical Center 18 4 269–271.
IEEE E. Öztürk, M. G. Uğur, Y. Özkan, A. Aydın, ve Ö. Balat, “En Genç İleri Evre Grade III Endometrium Karsinomu: Olgu Sunumu”, Turgut Özal Tıp Merk Derg, c. 18, sy. 4, ss. 269–271, 2011.
ISNAD Öztürk, Ebru vd. “En Genç İleri Evre Grade III Endometrium Karsinomu: Olgu Sunumu”. Journal of Turgut Ozal Medical Center 18/4 (Ağustos 2011), 269-271.
JAMA Öztürk E, Uğur MG, Özkan Y, Aydın A, Balat Ö. En Genç İleri Evre Grade III Endometrium Karsinomu: Olgu Sunumu. Turgut Özal Tıp Merk Derg. 2011;18:269–271.
MLA Öztürk, Ebru vd. “En Genç İleri Evre Grade III Endometrium Karsinomu: Olgu Sunumu”. Journal of Turgut Ozal Medical Center, c. 18, sy. 4, 2011, ss. 269-71.
Vancouver Öztürk E, Uğur MG, Özkan Y, Aydın A, Balat Ö. En Genç İleri Evre Grade III Endometrium Karsinomu: Olgu Sunumu. Turgut Özal Tıp Merk Derg. 2011;18(4):269-71.