Öz
Inroduction: Endometrail cancer, typically diagnosed in the postmenopausal years, is the most common gynecologic malignancy. Young women with endometrial carcinoma are considered to have a favorable prognosis with early stage, well differentiated lesions. In this report we present young patient with advanced stage endometrial adenocarcinoma who had poor prognosis. Case Report: A 23 year old female applied to the hospital because of postabortal bleeding despite revision curettage. Endometral sampling was perfomed and grade 3 endometrail adenocarcinoma was diagnosed. Athought total abdominal hysterectomy, bilateral salphingoopherectomy, pelvic-paraaortic lymphadenectomy, infracolic omentectomy and chemotherapy were performed, recurrence of the tumor was observed one year after the surgery. The patient died because of sepsis in 24 years old. Conclusion: In this report endometrial cancer was observed in 23 years old patient with no obvious risk factor. This report is the youngest advanced stage grade 3 endometrial adenocarcinoma in the literature. Further studies to evaluate the etyopathogenic mechanisms of endometrial cancer without risk factors are needed. Key words: Advanced Stage Endometrium Cancer; Youngest.
Anahtar Kelimeler
Kaynakça
- Jemal, A, Siegel, R, Ward, E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009; 59: 225.
- Gallup, DG, Stock, RJ. Adenocarcinoma of the endometrium in women 40 years of age or younger. Obstet Gynecol 1984; 64: 417
- Azim, A, Oktay, K. Letrozole for ovulation induction and fertility preservation by embryo cryopreservation in young women with endometrial carcinoma. Fertil Steril 2007; 88: 657.
- Cirns JD, Noble AJ, Bryant ME. Carcinoma of endometrium and polycystic ovaries in a 22-year-old patient. Can Med Assoc J 1967; 96:1473-6.
- Schmeler, KM, Soliman, PT, Sun, CC, et al. Endometrial cancer in young, normal-weight women. Gynecol Oncol 2005; 99: 388.
- Tran BN, Connell PP, Waggoner S, et al. Characteristics and outcome of endometrial carcinoma patients age 45 years and younger. Am J Clin Oncol 2000; 23: 476-80.
- Wang CB, Wang CJ, HuangHJ. Fertility-preserving treatment in young patients with endometrial adenocarcinoma. Cancer 2002; 94: 2192-8.
- Peterson EP. Endometrial carcinoma in young women. A clinical profile. Obstet Gynecol 1968; 31:702-7.
- Duska LR, Garrett A, Rueda BR. Endometrial cancer in women 40 years old or younger. Gynecol Oncol 2001; 83: 388-93.
- Morrow CP, Bundy BN, Kurman RJ. Relationship between surgical-pathological risk factors and outcome in clinical stageI and II carcinoma of the endometrium: a Gynecologic Oncology Group Study. Gynecol Oncol 1991; 40: 55-65.
- Berends MJ, Kleibeuker JH, de Vries EG, et al. The importance of family history in young patients with endometrial cancer. Eur J Obstet Gynecol Reprod Biol 1999; 82: 139-41.
Öz
Giriş: Sıklıkla posmenapozal dönemde izlenen endometrium karsinomu en sık görülen jinekolojik malignensidir. Literatürde genç endometrial karsinom vakalarının; polikistik over hastalığı zemininde gelişen diferansiye erken evre kanserler olduğu vurgulanmaktadır. Bu makalede genç yaşta izlenen, ileri evre, kötü prognozlu endometrium karsinomu vakası sunulmuştur. Olgu Sunumu: Abortus sonrası revizyon küretaj yapılmasına rağmen vajinal kanaması devam eden 23 yaşındaki hastaya endometrial biopsi uygulanmış, patolojik inceleme sonucu Grade 3 adenokarsinom olarak gelmiştir. Yapılan operasyonda 8000 cc asit mai boşaltılmış, total abdominal histerektomi, bilateral salfingooferektomi, parsiyel omentektomi, bilateral pelvik-paraaortik lenf nodu diseksiyonu uygulanmıştır. Altı kür taksol-karboplatin kemoterapisi alan hastada operasyondan yaklaşık bir yıl sonra nüks gelişmiş, verilen kemoterapiye yanıt alınamamıştır. Hasta sepsis sebebiyle 24 yaşında kaybedilmiştir. Sonuç: Bu makalede endometriun kanseri, hiçbir risk faktörü saptanmayan 23 yaşındaki hastada izlenmiştir. Bu hasta literatürde bizim saptadığımız en genç ileri evre grade 3 endometrium kanseri olgusudur. Risk faktörleri dışında endometrium kanseri etyopatogenezinde rol alan mekanizmaları ortaya koyacak yeni yayınlara ihtiyaç vardır. Anahtar kelimeler: İleri Evre Endometrium Kanseri; En Genç.
Anahtar Kelimeler
Kaynakça
- Jemal, A, Siegel, R, Ward, E, et al. Cancer statistics, 2009. CA Cancer J Clin 2009; 59: 225.
- Gallup, DG, Stock, RJ. Adenocarcinoma of the endometrium in women 40 years of age or younger. Obstet Gynecol 1984; 64: 417
- Azim, A, Oktay, K. Letrozole for ovulation induction and fertility preservation by embryo cryopreservation in young women with endometrial carcinoma. Fertil Steril 2007; 88: 657.
- Cirns JD, Noble AJ, Bryant ME. Carcinoma of endometrium and polycystic ovaries in a 22-year-old patient. Can Med Assoc J 1967; 96:1473-6.
- Schmeler, KM, Soliman, PT, Sun, CC, et al. Endometrial cancer in young, normal-weight women. Gynecol Oncol 2005; 99: 388.
- Tran BN, Connell PP, Waggoner S, et al. Characteristics and outcome of endometrial carcinoma patients age 45 years and younger. Am J Clin Oncol 2000; 23: 476-80.
- Wang CB, Wang CJ, HuangHJ. Fertility-preserving treatment in young patients with endometrial adenocarcinoma. Cancer 2002; 94: 2192-8.
- Peterson EP. Endometrial carcinoma in young women. A clinical profile. Obstet Gynecol 1968; 31:702-7.
- Duska LR, Garrett A, Rueda BR. Endometrial cancer in women 40 years old or younger. Gynecol Oncol 2001; 83: 388-93.
- Morrow CP, Bundy BN, Kurman RJ. Relationship between surgical-pathological risk factors and outcome in clinical stageI and II carcinoma of the endometrium: a Gynecologic Oncology Group Study. Gynecol Oncol 1991; 40: 55-65.
- Berends MJ, Kleibeuker JH, de Vries EG, et al. The importance of family history in young patients with endometrial cancer. Eur J Obstet Gynecol Reprod Biol 1999; 82: 139-41.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Ağustos 2011 |
| Yayımlandığı Sayı | Yıl 2011 Cilt: 18 Sayı: 4 |