Kanser Kemoterapisi ve Böbrek

Yıl 2009, Cilt: 16 Sayı: 1, 63 - 68, 01.02.2009

Mehmet Ali Erkurt İrfan Kuku Emin Kaya İsmet Aydoğdu

Öz

Kanser ilaçlarının tipine ve dozuna bağlı olarak serum kreatininin hafif yükselmesinden son dönem böbrek yetmezliğine kadar ciddi boyutta böbrek bozukluğu görülebilmektedir. Kemoterapi öncesi sağlanacak yeterli hidrasyonla nefrotoksisite büyük ölçüde önlenebilir. Kemoterapiye bağlı nefrotoksisitenin önlenmesi ile hastaların mortalite ve morbidite oranı azaltılabilir. Bu derlemede kemoterapiye bağlı böbrek bozukluğunu ve nefrotoksisitesi en sık gözlenen kanser ilaçlarının nefrotoksik etki mekanizmalarını değerlendirmeyi amaçladık. Anahtar kelimeler: Kanser, Kemoterapi, Nefrotoksisite, Mortalite

Anahtar Kelimeler

Kanser, Kemoterapi, Nefrotoksisite, Mortalite

Cancer Chemotherapy and Kidney

Öz

The nephrotoxicity of cancer chemotherapy varies from mild serum creatinine level elevation to end stage kidney failure depending on the type and dosage of the drug. Saline-based hydration confer protection against chemotherapy-induced nephrotoxicity. The mortality and morbidity rates can be decreased by preventing the chemotherapy-induced nephrotoxicity. In this compilation, we aimed evaluating the mechanisms of chemotherapy induced nephrotoxicity of the most frequently observed cancer drugs and kidney disorder depending on chemotherapy. Key words: Cancer, Chemotherapy, Nephrotoxicity, Mortality

Anahtar Kelimeler

Cancer, Chemotherapy, Nephrotoxicity, Mortality

Kaynakça

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