Öz
Objectives: Vitiligo is an acquired skin disorder resulting from the loss of functional melanocytes and is characterized by depigmented macular lesions. The etiopathogenesis of vitiligo has not been explained exactly yet. As a result of the studies that have been made for clarifying this mechanism, three basic theories have been suggested. Autoimmune theory, neural theory and autocytotoxic theory. In this issue, there are a lot of studies and several studies have been continued. Some of the present studies show that inflammatory parameters involves in vitiligo. As known, arachidonic acid is a PUFA and a key molecule for inflammation. In the literature, there is not a comprehensive study that investigates the relation between polyunsaturated fatty acid (PUFA) and vitiligo formation. Patients and Methods: In this study we aimed to investigate the possible relationship between vitiligo etiopatogenesis and serum fatty acids' composition. In this way we studied serum fatty acids' levels in healthy and patients with generalized active vitiligo. Serum fatty acids' levels were transformed to their methylesters, then analysed by gas cromotography. Results and Conclusion: We found that serum fatty acid levels except two kinds were similar to those of healty controls. On the other hand, palmitoleic acid levels were found decreased and Docosapenthaenoic acid levels were found increased (p<0.05). But, in general, our results clearly show that the serum composition of fatty acids in patients with generalized active vitiligo are not significantly different from those of healthy controls. Key words: Vitiligo, PUFA, Gas cromotography
Anahtar Kelimeler
Kaynakça
- Dammak I, Boudaya S, Ben Mansour R, El Gaied A, et al. A comparative study of oxidant–antioxidant status in stable and active vitiligo patients. Arch Dermatol Res 2006; 298:147–52
- Desmond J, Tobin NN, Swanson MR, Pittelkow M, et al. Melanocytes are not absent in lesional skin of long duration vitiligo. J Pathol 2000; 191: 407-16,
- LePoole IC, Das PK, van den Wijngaard RM, Bos JD, Westerhof W. Review of the etiopathomechanism of vitiligo: a convergence theory. Exp Dermatol 1993; 2: 53
- Han JJ, Iwasaki Y, Yamane T. Use of isopropanol as a modifier in a hexane- acetonitrile based mobile phase for the silver ion HPLC separation of positional isomers of triacylglycerols containing long chain polyunsaturated fatty acids J. High Resol. Chromatogr 1999; 22 (6): 357–61
- Ando H, Watabe H, Valencia JC, Yasumoto K, et al. Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: a new aspect of ubiquitin-proteasome function J Biol Chem 2004; 279(15):15427-33
- Saeki H, Oikawa A. Synthesis and degradation of tyrosinase in cultured melanoma cells. J Cell Physiol 1980; 104(2):171-5
- Jimenez M, Kameyama K, Maloy WL, et al. Mammalian tyrosinase: biosynthesis, processing, and modulation by melanocyte-stimulating hormone. Proc Natl Acad Sci 1988; 85(11):3830-4,
- Halaban R, Cheng E, Zhang Y, Moellmann G, et al. Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells. Proc Natl Acad Sci 1997; 94(12):6210-5
- Mosse CA, Hsu W, Engelhard VH. Tyrosinase degredation via two pathways during reverse translocation to the cytosol. Biochem Biophys Res Commun 2001; (285):313-9
- Koca R, Armutcu F, Altinyazar HC, Aurel A. Oxidant-antioxidant enzymes and lipid peroxidation in generalized vitiligo. Exp Dermatol 2004; 29:406-9
- Briganti S, Picardo M. Antioxidant activity, lipid peroxidation and skin diseases. What’s new. JEADV 2003; 17:663-9
- Yildirim M, Baysal V, Inaloz HS, Kesici D, Delibas N. The role of oxidants and antioxidants in generalized vitiligo.J Dermatol., 2003; 30:104-8
- Yilmaz O, Celik S, Cay M, Naziroglu M. protective role of intraperitoneally administrated vitamin E and selenium on the levels of total lipid, total cholesterol, and fatty acid composition of muscle and liver tissues in rats. J Cellular Biochem ; 64:233-41
- Lauretani F, Semba RD, Bandinelli S, et al. Plasma polyunsaturated fatty acids and the decline of renal function. Clin Chem 2008; 54(3):475-81
- Ando H, Funasaka Y, Oka M, Ohashi A, et al. Possible involvement of proteolytic degradation of tyrosinase in the regulatory effect of fatty acids on melanogenesis J Lipid Res 1999; 40:1312-20
- Ando H, Wen ZM, Kim HY, Valencia JC, et al. Intracellular composition of fatty acid affects the processing and function of tyrosinase through the ubiquitin– proteasome pathway. Biochem J 2006; 394: 43–50
- Ando H, Ryu A, Hashimoto A, · Oka M, Ichihashi M. Linoleic acid and á- linolenic acid lightens ultraviolet-induced hyperpigmentation of the skin. Arch Dermatol Res 1998; 290 : 375–81
- Picardo M, Passi S, Morrone A, Grandienetti M, Carlo A and Ippolito F. Antioxidant status in the blood of patients with active vitiligo. Pigment Cell Res ; 7:110-5
Öz
AMAÇ: Vitiligo fonksiyonel melanositlerin kaybı sonucu oluşan ve depigmente maküler lezyonlarla karakterize bir tür deri hastalığıdır. Oluşum mekanizması henüz aydınlatılabilmiş değildir. Bu mekanizmayı aydınlatabilmek üzere yapılan çalışmalar sonucunda 3 temel teori öne sürülmüştür; otoimmün teori, nöral teori ve otositotoksik teori. Bu doğrultuda araştırmacılar tarafından pek çok çalışma yapılmıştır ve yapılmaya devam etmektedir. Mevcut çalışmaların bir kısmı vitiligoda inflamasyonla ilişkili parametrelerin etkili olabileceği yönündedir. Bilindiği gibi, araşidonik asit çoklu doymamış bir yağ asididir (PUFA) ve inflamasyon prosesinde anahtar moleküldür. Literatürde vitiligo gelişimi ile doymamış yağ sitleri arasındaki ilişkiyi araştıran karşılaştırmalı bir çalışma bulunmamaktadır. YÖNTEM: Bu çalışmada serum yağ asidi kompozisyonu ile vitiligo oluşum mekanizması arasındaki olası ilişkinin araştırılması amaçlandı. Bu doğrultuda aktif generalize vitiligolu hastalar ile sağlıklı bireylerin serum yağ asidi düzeylerine bakıldı. Serum yağ asitleri önce yağ asidi metil esterlerine dönüştürüldü ve sonra gaz kromotografisi ile analiz edildi. SONUÇLAR VE YORUM: On yağ asidi düzeyinden ikisi dışındakiler kontrol gurubu ile aynı düzeylerde bulundu. Palmitik asit düzeyi kontrol gurubuna göre azalmış ve dokosapentaenoik asit düzeyleri ise kontrole göre artmış (p<0,05) olarak tespit edildi. Fakat, genel olarak aktif vitiligolu hastalar ile sağlıklı kontrol grubu arasında serum yağ asidi düzeyleri bakımından dikkate değer bir farklılık belirlenemedi. Anahtar kelimeler: Vitiligo, PUFA, Gaz kromotografi
Anahtar Kelimeler
Kaynakça
- Dammak I, Boudaya S, Ben Mansour R, El Gaied A, et al. A comparative study of oxidant–antioxidant status in stable and active vitiligo patients. Arch Dermatol Res 2006; 298:147–52
- Desmond J, Tobin NN, Swanson MR, Pittelkow M, et al. Melanocytes are not absent in lesional skin of long duration vitiligo. J Pathol 2000; 191: 407-16,
- LePoole IC, Das PK, van den Wijngaard RM, Bos JD, Westerhof W. Review of the etiopathomechanism of vitiligo: a convergence theory. Exp Dermatol 1993; 2: 53
- Han JJ, Iwasaki Y, Yamane T. Use of isopropanol as a modifier in a hexane- acetonitrile based mobile phase for the silver ion HPLC separation of positional isomers of triacylglycerols containing long chain polyunsaturated fatty acids J. High Resol. Chromatogr 1999; 22 (6): 357–61
- Ando H, Watabe H, Valencia JC, Yasumoto K, et al. Fatty acids regulate pigmentation via proteasomal degradation of tyrosinase: a new aspect of ubiquitin-proteasome function J Biol Chem 2004; 279(15):15427-33
- Saeki H, Oikawa A. Synthesis and degradation of tyrosinase in cultured melanoma cells. J Cell Physiol 1980; 104(2):171-5
- Jimenez M, Kameyama K, Maloy WL, et al. Mammalian tyrosinase: biosynthesis, processing, and modulation by melanocyte-stimulating hormone. Proc Natl Acad Sci 1988; 85(11):3830-4,
- Halaban R, Cheng E, Zhang Y, Moellmann G, et al. Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells. Proc Natl Acad Sci 1997; 94(12):6210-5
- Mosse CA, Hsu W, Engelhard VH. Tyrosinase degredation via two pathways during reverse translocation to the cytosol. Biochem Biophys Res Commun 2001; (285):313-9
- Koca R, Armutcu F, Altinyazar HC, Aurel A. Oxidant-antioxidant enzymes and lipid peroxidation in generalized vitiligo. Exp Dermatol 2004; 29:406-9
- Briganti S, Picardo M. Antioxidant activity, lipid peroxidation and skin diseases. What’s new. JEADV 2003; 17:663-9
- Yildirim M, Baysal V, Inaloz HS, Kesici D, Delibas N. The role of oxidants and antioxidants in generalized vitiligo.J Dermatol., 2003; 30:104-8
- Yilmaz O, Celik S, Cay M, Naziroglu M. protective role of intraperitoneally administrated vitamin E and selenium on the levels of total lipid, total cholesterol, and fatty acid composition of muscle and liver tissues in rats. J Cellular Biochem ; 64:233-41
- Lauretani F, Semba RD, Bandinelli S, et al. Plasma polyunsaturated fatty acids and the decline of renal function. Clin Chem 2008; 54(3):475-81
- Ando H, Funasaka Y, Oka M, Ohashi A, et al. Possible involvement of proteolytic degradation of tyrosinase in the regulatory effect of fatty acids on melanogenesis J Lipid Res 1999; 40:1312-20
- Ando H, Wen ZM, Kim HY, Valencia JC, et al. Intracellular composition of fatty acid affects the processing and function of tyrosinase through the ubiquitin– proteasome pathway. Biochem J 2006; 394: 43–50
- Ando H, Ryu A, Hashimoto A, · Oka M, Ichihashi M. Linoleic acid and á- linolenic acid lightens ultraviolet-induced hyperpigmentation of the skin. Arch Dermatol Res 1998; 290 : 375–81
- Picardo M, Passi S, Morrone A, Grandienetti M, Carlo A and Ippolito F. Antioxidant status in the blood of patients with active vitiligo. Pigment Cell Res ; 7:110-5
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Haziran 2008 |
| Yayımlandığı Sayı | Yıl 2008 Cilt: 15 Sayı: 3 |