An Evaluation of the Efficacy of Lornoxicam in Acute Renal Colic Treatment

Yıl 2008, Cilt: 15 Sayı: 1, 1 - 3, 01.02.2008

Gökhan Temeltaş Çağrı Asan Talha Müezzinoğlu Coşkun Büyüksu

Öz

Purpose: In order to provide analgesia in renal colic, related to acute urinary obstruction, many different agents are used. Use of prostaglandin synthesis inhibitors is very common for this purpose. In our study, we aim to evaluate the analgesic effect of lornoxicam, included in above mentioned group, in renal colic treatment. Materials and Methods: The patients, who were taken to emergency room due to renal colic, were assigned into two group. Before any treatment, they were evaluated with visual analog pain scale, using darkening color scores between 0 to 10. Group 1: 8mg injectable lornoxicam was administrated, Grup 2: 75mg diclofenac sodium I.M was injected. Following treatment, at 15, 30, and 60th minutes, all patients were reevaluated for pain by using visual analog scale. Results: Initially, 213 patients were recruited for baseline evaluation and 129 of them, were included in the study. Before treatment, mean pain scores of the patients in Group 2 were found to be (S0) 6.10, whereas before treatment mean pain scores of the patients in Group 1 were found to be (S0) 6.04, (p=0.868). While means of pain scores (S15, S30, S60) at 15, 30, and 60th were found as 1.46, 0.84, and 0.63 respectively in Group 1, in Group 2, these values were found 3.75, 1.96, and 1.50 respectively and it was found that there was a statistically significant difference between the values (S15: p<0.001, S30: p=0.001, S60: p=0.01). Conclusions: Lornoxicam provides an effective analgesia within a short time in acute renal colic treatment and can be tolerated well by the patients. Lornoxicam may be one of the good alternatives for renal colic treatment. Key words: Acute renal colic, Lornoxicam, Treatment

Anahtar Kelimeler

Acute renal colic, Lornoxicam, Treatment

Akut Renal Kolik Tedavisinde Lornoksikam’ın Etkinliğinin Değerlendirilmesi

Öz

Amaç:Akut üriner obstrüksiyonla ilişkili renal koliğin analjezisini sağlamak için farklı ajanlar kullanılmıştır.Bu konuda sıklıkla prostaglandin sentez inhibitörleri kullanılır.Çalışmamızda renal kolik tedavisinde yukarıda adı geçen gruba dahil olan lornoksikamın analjezik etkinliğini araştırmayı amaçladık. Gereç ve Yöntem: Renal kolik nedeniyle acil servise gelen hastalar iki gruba ayrıldı. Herhangibir tedaviden önce hastalar 0 ile 10 arasında renkleri koyulaşarak skorlanan visüel analog ağrı skorlaması ile değerlendirildi.Birinci gruba 8 mg lornoksikam, ikinci gruba 75 mg IM diklofenak sodyum enjekte edildi.Tedaviyi takiben bütün hastalardaki ağrı 15, 30 ve 60. dakikalarda tekrar yüzeyel analog skala ile değerlendirildi. Sonuçlar:Başlangıçta temel değerlendirme için 213 hasta seçildi bunların seçilme kriterlerine sahip 129 u da çalışamaya dahildi.Tedavi öncesi grup 2nin ortalama ağrı skoru (S0) 6.10 iken birinci grubun skoru (S0) 6.04 bulundu (p=0,868). Hastaların 15, 30 ve 60. dakikalarda (S15, S30, S60 ) ortalama ağrı skorları birinci grupta sırasıyla 1.46, 0.84 ve 0.63 ikinci grupta bu değerler sırasıyla 3.75, 1.96 ve 1.50 bulundu ki bu değerler arasındaki fark istatistiksel olarak anlamlı bulundu ( S15 : p<0.001, S30 : p=0,001, S60 : p=0,01). Karar: Lornoksikam akut renal koliğin tedavisinde hastalar tarafından iyi tolere edilen kısa zamanda etkili bir analjezi sağlar.Lornoksikam renal koliğin tedavisinde iyi bir alternatif olabilir. Anahtar kelimeler: Akut renal kolik, Lornoksikam, Tedavi

Anahtar Kelimeler

Akut renal kolik, Lornoksikam, Tedavi

Kaynakça

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• Address for Correspondence: Gökhan TEMELTAS
• Celal Bayar University, School of Medicine
• Department of Urology, 45010 Manisa/ TURKEY. Tel : [phone] Fax : [phone]
• E-mail: [e-mail]