Öz
Gliomatosis cerebri is a rare diffuse involvement of the central nervous system by a malignant glioma that permeates the brain extensively without destroying the neural architecture. It involves more than two of the lobes. Oligodedroglial component can be predictive for a better prognosis. This is a report of two patients: a 33-year-old female patient and a 58-year-old male patient. A stereotactic biopsy was performed for our first patient. She was diagnosed with grade 2 astrocytoma. The second case was a grade 3 patient who was diagnosed with tumour infiltration in line with gliomatosis cerebri. Both cases underwent external beam radiotherapy at 44 Gy and 50 Gy, respectively, with a helical tomotherapy device. The patients tolerated the cure quite well and no acute complications (except for grade 1 skin reactions) were observed during the therapy. Radiotherapy volume and treatment dose are still controversial in the treatment of gliomatosis cerebri. Partial or whole brain radiotherapy can be applied
Anahtar Kelimeler
Kaynakça
- Nevin S. Gliomatosis cerebri.Brain.1938;170-91.
- Kleihues P,Cavenee WK.World Health Organization classification of tumors.Pathology and genetics of tumors of the central nervous system.Lyon:IARC Press,2000.
- Elshaikh MA,Stevens GH,Peereboom DM,Cohen BH,Prayson RA,Lee SY,Barnett GH,Suh JH.Gliomatosis Cerebri:Treatment results with Radiotherapy alone. Cancer. 2002 Nov 1;95(9):2027-31.
- Bendszus M,Marmer-Metz M,Klein R,et al.MR Spectroscopy in gliomatosis cerebri.AJNR Am J Neuroradial.2000;21:375-380
- Essig M, Schlemmer HP, Tronnier V, Hawighorst H, Wirtz R, van Kaick G. Fluid-attenuated inversion-recovery MR imaging of gliomatosis cerebri. Eur Radiol. 2001;11(2):303-8.
- Plowman PN, Saunders CA, Maisey MN. Gliomatosis cerebri: disconnection of the cortical grey matter, demonstrated on PET scan. Br J Neurosurg. 1998 Jun;12(3):240-4.
- Cozad SC, Townsend P, Morantz RA, Jenny AB, Kepes JJ, Smalley SR. Gliomatosis cerebri. Results with radiation therapy. Cancer. 1996 Oct 15;78(8):1789-93.
- Fallentin E, Skriver E, Herning M, Broholm H. Gliomatosis cerebri--an appropriate diagnosis? Case reports. Acta Radiol. 1997 May;38(3):381-90.
- Kim DG, Yang HJ, Park IA, Chi JG, Jung HW, Han DH, Choi KS, Cho BK. Gliomatosis cerebri: clinical features, treatment, and prognosis. Acta Neurochir (Wien). 1998;140(8):755-62.
- Artigas J,Cervos-Navarro,Iglesias JR,Ebhardt G.Gliomatosis cerebri:clinical and histopathologic findings.Clin Neuropathol.1985;4:135-48
- Taillibert S, Chodkiewicz C, Laigle-Donadey F, Napolitano M, Cartalat-Carel S, Sanson M. Gliomatosis cerebri: a review of 296 cases from the ANOCEF database and the literature. J Neurooncol. 2006 Jan;76(2):201-5.
- Perkins GH, Schomer DF, Fuller GN, Allen PK, Maor MH. Gliomatosis cerebri: improved outcome with radiotherapy. Int J Radiat Oncol Biol Phys. 2003 Jul 15;56(4):1137-46.
- O'Reilly SM, Newlands ES, Glaser MG, Brampton M, Rice-Edwards JM, Illingworth RD, Richards PG, Kennard C, Colquhoun IR, Lewis P, et al. Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours. Eur J Cancer. 1993;29A(7):940-2.
- Benjelloun A, Delavelle J, Lazeyras F, Dietrich PY. Possible efficacy of temozolomide in a patient with gliomatosis cerebri. Neurology. 2001 Nov 27;57(10):1932-3.
Öz
Gliomatozis serebri, oldukça nadir görülen, beyinde en az iki lobu tutan, nöral yapıların korunduğu, diffüz neoplastik glial hücre
proliferasyonudur. Oligodedroglial komponent varlığı prognoz açısından daha iyidir. Olgularımız 33 yaşında bayan ve 58 yaşında erkek
hastadır. Birinci olgumuzda stereotaktik biyopsi yapılmış. Grade 2, astrositom olarak değerlendirilmiş. İkinci olgumuz ise biyopsi sonucu
Grade 3, Gliomatozis serebri ile uyumlu tümör infiltrasyonu olarak değerlendirilmiş. Hastalarımıza Helikal Tomoterapi cihazında sırasıyla 44
Gy ve 50 Gy eksternal radyoterapi uygulandı. Hastalar tedaviyi iyi tolere etti ve tedavi süresince grade 1 cilt reaksiyonu dışında akut
komplikasyon gözlenmedi. Gliomatozis serebride radyoterapi volümü, tedavi dozu tartışmalıdır. Tüm beyin veya parsiyel radyoterapi
uygulanabilmektedir
Anahtar Kelimeler
Kaynakça
- Nevin S. Gliomatosis cerebri.Brain.1938;170-91.
- Kleihues P,Cavenee WK.World Health Organization classification of tumors.Pathology and genetics of tumors of the central nervous system.Lyon:IARC Press,2000.
- Elshaikh MA,Stevens GH,Peereboom DM,Cohen BH,Prayson RA,Lee SY,Barnett GH,Suh JH.Gliomatosis Cerebri:Treatment results with Radiotherapy alone. Cancer. 2002 Nov 1;95(9):2027-31.
- Bendszus M,Marmer-Metz M,Klein R,et al.MR Spectroscopy in gliomatosis cerebri.AJNR Am J Neuroradial.2000;21:375-380
- Essig M, Schlemmer HP, Tronnier V, Hawighorst H, Wirtz R, van Kaick G. Fluid-attenuated inversion-recovery MR imaging of gliomatosis cerebri. Eur Radiol. 2001;11(2):303-8.
- Plowman PN, Saunders CA, Maisey MN. Gliomatosis cerebri: disconnection of the cortical grey matter, demonstrated on PET scan. Br J Neurosurg. 1998 Jun;12(3):240-4.
- Cozad SC, Townsend P, Morantz RA, Jenny AB, Kepes JJ, Smalley SR. Gliomatosis cerebri. Results with radiation therapy. Cancer. 1996 Oct 15;78(8):1789-93.
- Fallentin E, Skriver E, Herning M, Broholm H. Gliomatosis cerebri--an appropriate diagnosis? Case reports. Acta Radiol. 1997 May;38(3):381-90.
- Kim DG, Yang HJ, Park IA, Chi JG, Jung HW, Han DH, Choi KS, Cho BK. Gliomatosis cerebri: clinical features, treatment, and prognosis. Acta Neurochir (Wien). 1998;140(8):755-62.
- Artigas J,Cervos-Navarro,Iglesias JR,Ebhardt G.Gliomatosis cerebri:clinical and histopathologic findings.Clin Neuropathol.1985;4:135-48
- Taillibert S, Chodkiewicz C, Laigle-Donadey F, Napolitano M, Cartalat-Carel S, Sanson M. Gliomatosis cerebri: a review of 296 cases from the ANOCEF database and the literature. J Neurooncol. 2006 Jan;76(2):201-5.
- Perkins GH, Schomer DF, Fuller GN, Allen PK, Maor MH. Gliomatosis cerebri: improved outcome with radiotherapy. Int J Radiat Oncol Biol Phys. 2003 Jul 15;56(4):1137-46.
- O'Reilly SM, Newlands ES, Glaser MG, Brampton M, Rice-Edwards JM, Illingworth RD, Richards PG, Kennard C, Colquhoun IR, Lewis P, et al. Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours. Eur J Cancer. 1993;29A(7):940-2.
- Benjelloun A, Delavelle J, Lazeyras F, Dietrich PY. Possible efficacy of temozolomide in a patient with gliomatosis cerebri. Neurology. 2001 Nov 27;57(10):1932-3.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 17 Nisan 2015 |
| Yayımlandığı Sayı | Yıl 2015 Cilt: 22 Sayı: 1 |
