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Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature

Yıl 2015, Cilt: 22 Sayı: 2, 125 - 127, 11.12.2015

Öz

Pleomorphic adenoma is the most common benign salivary gland neoplasm (%75-80). It is found mostly in the parotid gland in middle-aged women. The optimal treatment is superficial or total parotidectomy with facial nerve preservation, which results in local control rates of 95% or higher. Radiotherapy (RT) is indicated for ositive margins, unresectable tumours, and multifocal recurrences after prior resection. Local control rates after RT for microscopic and gross residual tumour are approximately 80% to 85% and 40% to 60%, respectively. In this article, we share our experience of 2 cases of recurrent pleomorphic adenoma.

Key Words: Pleomorphic Adenoma; Radiotherapy; Treatment.

Kaynakça

  • Mendenhall WM, Mendenhall CM, Werning JW, Malyapa RS, Mendenhall NP. Salivary gland pleomorphic adenoma. Am J Clin Oncol 2008;31(1):95-9.
  • Laccourreye H, Laccourreye O, Cauchois R, et al. Total conservative parotidectomy for primary benign pleomorphic adenoma of the parotid gland: a 25-year experience with 229 patients. Laryngoscope 1994;104:1487-94.
  • Satar B, Gerek M, Yetişer S, Akkaya A, Özkaptan Y. Major Tükrük Bezi Tümörleri: 93 Olgunun Analizi. Turkiye Klinikleri J E.N.T 2001;1(3):123-8.
  • Ohtake S, Cheng J, Ida H, et al. Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. J Oral Pathol Med 2002;31:590-7.
  • Nouraei SA, Ferguson MS, Clarke PM, et al. Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg 2006;132:788-93.
  • Alves FA, Perez DE, Almeida OP, et al. Pleomorphic adenoma of the submandibula gland: clinicopathological and immunohistochemical features of 60 cases in Brazil. Arch Otolaryngol Head Neck Surg 2002;128:1400-03.
  • Hamada T, Matsukita S, Goto M,et al. Mucin expression in pleomorphic adenoma of salivary gland: a potential role for MUC1 as a marker to predict recurrence. J Clin Pathol 2004;57:813-21.
  • Wallace AS, Morris CG, Kirwan JM, Werning JW, Mendenhall WM. Radiotherapy for pleomorphic adenoma. Am J Otolaryngol 2013;34(1):36-40.
  • Wittekindt C, Streubel K, Arnold G, et al. Recurrent pleomorphic adenoma of the parotid gland: analysis of 108 consecutive patients. Head Neck 2007;29:822-8.
  • Dawson AK, Orr JA. Long-term results of local excision and radiotherapy in pleomorphic adenoma of the parotid. Int J Radiat Oncol Biol Phys 1985;11(3):451-5.
  • Chen AM, Garcia J, Bucci MK, et al. Recurrent pleomorphic adenoma of the parotid gland: long-term outcome of patients treated with radiation therapy. Int J Radiat Oncol Biol Phys 2006;66:1031-5.
  • Liu FF, Rotstein L, Davison AJ, et al. Benign parotid adenomas: a review of the Princess Margaret Hospital experience. Head Neck 1995;17:177-83.
  • Makeieff M, Pelliccia P, Letois F, et al. Recurrent pleomorphic adenoma: results of surgical treatment. Ann Surg Oncol 2010;17:3308-13.
  • Ravasz LA, Terhaard CH, Hordijk GJ. Radiotherapy in epithelial tumors of the parotid gland: case presentation and literature review. Int J Radiat Oncol Biol Phys 1990;19(1):55-9.
  • Barton J, Slevin NJ, Gleave EN. Radiotherapy for pleomorphic adenoma of the parotid gland. Int J Radiat Oncol Biol Phys 1992;22(5):925-8.
  • Samson MJ, Metson R, Wang CC, et al. Preservation of the facial nevre in the management of recurrent pleomorphic adenoma. Laryngoscope 1991;101:1060-2.
  • Hodge CW, Morris CG, Werning JW, et al. Role of radiotherapy for pleomorphic adenoma. Am J Clin Oncol 2005;28:148-51.
  • Douglas JG, Einck J,Austin-Seymour M,et al. Neutron radiotherapy for recurrent pleomorphic adenomas of major salivary glands. Head Neck 2001;23:1037-42.

Journal of Turgut Ozal Medical Center

Yıl 2015, Cilt: 22 Sayı: 2, 125 - 127, 11.12.2015

Öz

Pleomorfik adenomlar tükrük bezlerinin en sık görülen iyi huylu neoplazmlarıdır . Genelde orta yaşlı kadınlarda ve parotis bezinde bulunur. Optimal tedavi şekli fasial siniri koruyarak yapılan superfisyal veya total parotidektomidir. Cerrahi ile %95 ve üzerinde başarı vardır. Radyoterapi(RT) pozitif cerrahi sınırda, unrezektabl hastalıkta ve cerrahi sonrası multifokal nüksde kullanılır. RT sonrası lokal kontrol mikroskopik hastalıkta %80-85 ve gros rezidüel hastalıkta %40-60 arasındadır. Biz de bu makalede cerrahi sonrası nüks eden 2 olguyu adjuvan RT deneyimimizi paylaştık

Kaynakça

  • Mendenhall WM, Mendenhall CM, Werning JW, Malyapa RS, Mendenhall NP. Salivary gland pleomorphic adenoma. Am J Clin Oncol 2008;31(1):95-9.
  • Laccourreye H, Laccourreye O, Cauchois R, et al. Total conservative parotidectomy for primary benign pleomorphic adenoma of the parotid gland: a 25-year experience with 229 patients. Laryngoscope 1994;104:1487-94.
  • Satar B, Gerek M, Yetişer S, Akkaya A, Özkaptan Y. Major Tükrük Bezi Tümörleri: 93 Olgunun Analizi. Turkiye Klinikleri J E.N.T 2001;1(3):123-8.
  • Ohtake S, Cheng J, Ida H, et al. Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. J Oral Pathol Med 2002;31:590-7.
  • Nouraei SA, Ferguson MS, Clarke PM, et al. Metastasizing pleomorphic salivary adenoma. Arch Otolaryngol Head Neck Surg 2006;132:788-93.
  • Alves FA, Perez DE, Almeida OP, et al. Pleomorphic adenoma of the submandibula gland: clinicopathological and immunohistochemical features of 60 cases in Brazil. Arch Otolaryngol Head Neck Surg 2002;128:1400-03.
  • Hamada T, Matsukita S, Goto M,et al. Mucin expression in pleomorphic adenoma of salivary gland: a potential role for MUC1 as a marker to predict recurrence. J Clin Pathol 2004;57:813-21.
  • Wallace AS, Morris CG, Kirwan JM, Werning JW, Mendenhall WM. Radiotherapy for pleomorphic adenoma. Am J Otolaryngol 2013;34(1):36-40.
  • Wittekindt C, Streubel K, Arnold G, et al. Recurrent pleomorphic adenoma of the parotid gland: analysis of 108 consecutive patients. Head Neck 2007;29:822-8.
  • Dawson AK, Orr JA. Long-term results of local excision and radiotherapy in pleomorphic adenoma of the parotid. Int J Radiat Oncol Biol Phys 1985;11(3):451-5.
  • Chen AM, Garcia J, Bucci MK, et al. Recurrent pleomorphic adenoma of the parotid gland: long-term outcome of patients treated with radiation therapy. Int J Radiat Oncol Biol Phys 2006;66:1031-5.
  • Liu FF, Rotstein L, Davison AJ, et al. Benign parotid adenomas: a review of the Princess Margaret Hospital experience. Head Neck 1995;17:177-83.
  • Makeieff M, Pelliccia P, Letois F, et al. Recurrent pleomorphic adenoma: results of surgical treatment. Ann Surg Oncol 2010;17:3308-13.
  • Ravasz LA, Terhaard CH, Hordijk GJ. Radiotherapy in epithelial tumors of the parotid gland: case presentation and literature review. Int J Radiat Oncol Biol Phys 1990;19(1):55-9.
  • Barton J, Slevin NJ, Gleave EN. Radiotherapy for pleomorphic adenoma of the parotid gland. Int J Radiat Oncol Biol Phys 1992;22(5):925-8.
  • Samson MJ, Metson R, Wang CC, et al. Preservation of the facial nevre in the management of recurrent pleomorphic adenoma. Laryngoscope 1991;101:1060-2.
  • Hodge CW, Morris CG, Werning JW, et al. Role of radiotherapy for pleomorphic adenoma. Am J Clin Oncol 2005;28:148-51.
  • Douglas JG, Einck J,Austin-Seymour M,et al. Neutron radiotherapy for recurrent pleomorphic adenomas of major salivary glands. Head Neck 2001;23:1037-42.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Tr
Bölüm Makaleler
Yazarlar

Öztun Temelli Bu kişi benim

Cemal Ekici Bu kişi benim

Yayımlanma Tarihi 11 Aralık 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 22 Sayı: 2

Kaynak Göster

APA Temelli, Ö., & Ekici, C. (2015). Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature. Journal of Turgut Ozal Medical Center, 22(2), 125-127.
AMA Temelli Ö, Ekici C. Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature. Turgut Özal Tıp Merk Derg. Aralık 2015;22(2):125-127.
Chicago Temelli, Öztun, ve Cemal Ekici. “Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature”. Journal of Turgut Ozal Medical Center 22, sy. 2 (Aralık 2015): 125-27.
EndNote Temelli Ö, Ekici C (01 Aralık 2015) Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature. Journal of Turgut Ozal Medical Center 22 2 125–127.
IEEE Ö. Temelli ve C. Ekici, “Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature”, Turgut Özal Tıp Merk Derg, c. 22, sy. 2, ss. 125–127, 2015.
ISNAD Temelli, Öztun - Ekici, Cemal. “Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature”. Journal of Turgut Ozal Medical Center 22/2 (Aralık 2015), 125-127.
JAMA Temelli Ö, Ekici C. Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature. Turgut Özal Tıp Merk Derg. 2015;22:125–127.
MLA Temelli, Öztun ve Cemal Ekici. “Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature”. Journal of Turgut Ozal Medical Center, c. 22, sy. 2, 2015, ss. 125-7.
Vancouver Temelli Ö, Ekici C. Role of Radiotherapy in Parotid Pleomorphic Adenoma: Two Case Reports and a Review of the Literature. Turgut Özal Tıp Merk Derg. 2015;22(2):125-7.