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Investigation of the Relation Between Intraarticular Bleedings and Symptom Severity of Attention Deficit Hyperactivity Disorder in Children and Adolescents with Haemophilia

Yıl 2015, Cilt: 22 Sayı: 3, 171 - 175, 14.12.2015

Öz

Aim: Intra-articular bleedings in haemophilia patients and movement restrictions and joint deformities that occur as a result of these bleedings constitute an important health problem and deteriorate the quality of life for children. The purpose of this study is to investigate the relation between intra-articular bleedings and symptom severity of attention deficit hyperactivity disorder and disruptive behavior disorders in children and adolescents with haemophilia.

Method: 24 boys with haemophilia were included in the study. During the interviews with children and their mothers, their sociodemographic features and frequency of intra-articular bleedings were examined. Following the interviews, mothers were asked to fill out the Disruptive Behavior Disorder Screening and Rating Scale based on Turgay Diagnostic and Statistical Manual of Mental Disorders Fourth Edition, Text Revision. SPSS for Windows 16.0 software program was used for the statistical analysis of the study.

Results: As a result of the correlation analysis, no relation was determined between the symptom severity of attention deficit and frequency of intra-articular bleeding (p>0.05). A statistically significant positive relation was determined between the frequency of bleedings within the knee and ankle joints and symptom severities of hyperactivity, impulsivity, oppositional defiant disorder, and conduct disorder (p<0.05). No significant relation was detected between the frequency of bleedings within the elbow joint and subscale scores (p>0.05).

Conclusion: The results of our study have made us think that the frequency of bleeding especially within the knee and ankle joints is related with the symptom severity of hyperactivity/impulsivity, oppositional defiant disorder, and conduct disorder, and children having frequent bleedings within these joints should be evaluated from this aspect along with prophylactic treatment.

Key Words: Hemophilia; Attention Deficit And Hyperactivity Disorder; Intraarticular Bleeding.

Kaynakça

  • Zülfikar B. Hemofili el kitabı. 1. Baskı. İstanbul: Türkiye Hemofili Derneği Yayınları; 1997.
  • Ekşi A. Çocuk ve adölesan konsültasyon-liyezon psikiyatrisi. Çocuk ve Ergen Psikiyatrisi Günleri Kongre Kitabı. İzmir: Saray Kitabevi; 1994.
  • Büküşoğlu N, Solak U, Yılmaz D. Evaluation of the psychological status of the patients with hemophilia. J Psychosomatic Research 2005;59:25-9.
  • Erermiş HS. Kronik kan hastalıkları ve çocuk. Tüzün DÜ, Hergüner S, editörler. Çocuk hastalıklarında biyopsikosoyal yaklaşım. 1. Baskı. İstanbul: Epsilon yayıncılık; 2007. p.250-64.
  • Öztürk M, Zülfikar B, Sayar K, Uğurad I, Zoroğlu S, Tüzün Ü ve ark. Hemofilili çocuklar ve annelerinde emosyonel zorlanma. Yeni symposium 2005;43:157-62.
  • Kavaklı K, Şenol S, Genç Ekti R, Balkan C, Güngör N. Ege üniversitesi hastanesinde tedavi gören hemofili hastalarının sosyo-demografik özellikleri ile yaşam kalitelerinin incelenmesi. Ege Pediatri Bülteni 2005;13:91-5.
  • Zülfikar B. Hemofili. Türkiye Klinikleri Pediatrik Bilimler Dergisi 2005;1:53-68.
  • Yörükoğlu A. Çocuk Ruh Sağlığı. 1. Baskı. İstanbul: Özgür yayınları; 1996.
  • Polanczyk G, De Lima M, Horta B, Biederman J, Rohde L. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 2007;164:942-8.
  • Merrill R M, Lyon JL, Baker RK, Gren LH. Attention deficit hyperactivity disorder and increased risk of injury. Adv Med Sci 2009;54:20-6.
  • Shilon Y, Pollak Y, Aran A, Shaked S, Gross‐Tsur V. Accidental injuries are more common in children with attention deficit hyperactivity disorder compared with their non‐affected siblings. Child Care Health Dev 2012;38:366-70.
  • 12-Van den Ban E, Souverein P, Meijer W, Van Engeland H, Swaab H, Egberts T et al. Association between ADHD drug use and injuries among children and adolescents. Eur Child Adolesc Psychiatry 2014;23:95-102.
  • Marcus SC, Wan G J, Zhang H F, Olfson M. Injury among stimulant-treated youth with ADHD. J Atten Disord 2008;12:64-9.
  • Pastor PN, Reuben CA. Identified attention-deficit/hyperactivity disorder and medically attended, nonfatal injuries: US school-age children, 1997–2002. Ambul Pediatr 2006;6:38-44.
  • Tai YM, Gau SSF, Gau C S. Injury-proneness of youth with attention-deficit hyperactivity disorder: A national clinical data analysis in Taiwan. Res Dev Disabil 2013;34:1100-8.
  • Rowe R, Maughan B, Goodman R. Childhood psychiatric disorder and unintentional injury: findings from a national cohort study. J Pediatr Psychol 2004;29:119-30.
  • Brehaut JC, Miller A, Raina P, McGrail KM. Childhood behavior disorders and injuries among children and youth: a population-based study. Pediatrics 2003;111:262-9.
  • Pless IB, Taylor HG, Arsenault L. The relationship between vigilance deficits and traffic injuries involving children. Pediatrics 1995;95:219-24.
  • Rosen BN, Peterson L. Gender differences in children's outdoor play injuries: A review and an integration. Clin Psychol 1990;10:187-205.
  • Uslu M, Uslu R, Eksioglu F, Ozen NE. Children with fractures show higher levels of impulsive-hyperactive behavior. Clin Orthop Relat Res 2007;460:192-5.
  • Barkley RA. ADHD and accident proneness. The ADHD Report 2002;10:2-6.
  • Chen G, Smith GA, Deng S, Chen D, Kelleher K, Xiang H. Psychological symptoms and nonfatal unintentional injuries among Chinese adolescents: a prospective study. J Adolesc Health 2005;37:460-6.
  • Wodrich DL, Recht M, Gradowski M, Wagner L. Is attention deficit hyperactivity disorder over-represented mong HIV-seronegative boys with haemophilia? Preliminary results from our centre. Haemophilia 2003;9:593–7.
  • Spencer ML, Wodrich DL, Schultz W, Wagner L, Recht M. Inattention, hyperactivity-impulsivity, academic skills and psychopathology in boys with and without haemophilia. Haemophilia 2009;15:701-6.
  • Turgay, A. Disruptive Behavior Disorders: Child and Adolescent Screening and Rating Scales for Children, Adolescents, Parents and Teachers. Michigan: Integrative Therapy Institute Publication; 1994.
  • Ercan ES, Amado S, Somer O, Çıkoğlu S. Dikkat eksikliği hiperaktivite bozukluğu ve yıkıcı davranım bozuklukları için bir test bataryası geliştirme çabası. Çocuk ve Gençlik Ruh Sağlığı Dergisi 2001;8:132-44.
  • Kavaklı K. Hemofililer. Anak SS, Aydoğan G, Çetin M, İrken G, Kemahlı S, Öztürk G, ve ark. Editörler. Pediatrik Hematoloji. 1. Baskı. İstanbul: İstanbul Medikal Yayıncılık; 2011. p.479-94.
  • Shapiro AD, Donfield SM, Lynn HS, Cool VA, Stehbens JA, Hunsberger SL, et al. Defining the impact of hemophilia: the Academic Achievement in Children with Hemophilia Study Pediatrics 2001;108:1-6.
  • DiScala C, Lescohier I, Barthel M, Li G. Injuries to children with attention deficit hyperactivity disorder. Pediatrics 1998;102:1415-21.
  • Lee LC, Harrington RA, Chang JJ, Connors SL. Increased risk of injury in children with developmental disabilities. Res Dev Disabil 2008;29:247-55.

Journal of Turgut Ozal Medical Center

Yıl 2015, Cilt: 22 Sayı: 3, 171 - 175, 14.12.2015

Öz

Amaç: Hemofili hastalarında ortaya çıkan eklem içi kanamalar ve buna bağlı ortaya çıkan hareket kısıtlılıkları, eklem deformiteleri önemli bir sağlık sorunu oluşturmakta, çocuğun yaşam kalitesini bozmaktadır. Çalışmamızda hemofilili çocuk ve ergenlerde eklem içi kanamalar ile dikkat eksikliği ve hiperaktivite bozukluğu ve yıkıcı davranış bozuklukları belirti şiddeti arasındaki ilişkinin incelenmesi amaçlanmıştır. Yöntem: Çalışmaya hemofilili 24 erkek çocuk dahil edildi. Çocuklar ve anneleri ile yapılan görüşmede sosyodemografik özellikler ve eklem içi kanama sıklığı sorgulandı. Görüşmenin ardından olguların anneleri tarafından Turgay çocuk ve ergenlerde davranım bozuklukları için ruhsal bozuklukların tanısal ve sayımsal el kitabı 4. Baskısına dayalı tarama ve değerlendirme ölçeği dolduruldu. Çalışmanın istatistiksel analizinde SPSS for Windows 16.0 paket programı kullanıldı. Bulgular: Yapılan korelasyon analizinde dikkat eksikliği belirti şiddeti ile hiçbir eklem içi kanama sıklığı arasında ilişki saptanmadı (p>0,05). Diz ve ayak bilek eklemleri içine olan kanama sıklığı ile hiperktivite/impulsivite, karşıt olma karşı gelme bozukluğu ve davranım bozukluğu belirti şiddeti arasında istatistiksel olarak anlamlı düzeyde pozitif bir ilişki saptandı (p0,05). Sonuç: Çalışma sonuçlarımız özellikle diz ve ayak bileği eklemlerindeki kanama sıklığının hiperaktivite/impulsivite, karşıt olma karşı gelme bozukluğu ve davranım bozukluğu belirti şiddeti ile ilişkili olduğunu, proflaktik tedavinin yanında bu eklemlerde sık kanama yaşayan çocukların bu açıdanda değerlendirilmesinin fayda sağlayabileceğini düşündürmektedir

Kaynakça

  • Zülfikar B. Hemofili el kitabı. 1. Baskı. İstanbul: Türkiye Hemofili Derneği Yayınları; 1997.
  • Ekşi A. Çocuk ve adölesan konsültasyon-liyezon psikiyatrisi. Çocuk ve Ergen Psikiyatrisi Günleri Kongre Kitabı. İzmir: Saray Kitabevi; 1994.
  • Büküşoğlu N, Solak U, Yılmaz D. Evaluation of the psychological status of the patients with hemophilia. J Psychosomatic Research 2005;59:25-9.
  • Erermiş HS. Kronik kan hastalıkları ve çocuk. Tüzün DÜ, Hergüner S, editörler. Çocuk hastalıklarında biyopsikosoyal yaklaşım. 1. Baskı. İstanbul: Epsilon yayıncılık; 2007. p.250-64.
  • Öztürk M, Zülfikar B, Sayar K, Uğurad I, Zoroğlu S, Tüzün Ü ve ark. Hemofilili çocuklar ve annelerinde emosyonel zorlanma. Yeni symposium 2005;43:157-62.
  • Kavaklı K, Şenol S, Genç Ekti R, Balkan C, Güngör N. Ege üniversitesi hastanesinde tedavi gören hemofili hastalarının sosyo-demografik özellikleri ile yaşam kalitelerinin incelenmesi. Ege Pediatri Bülteni 2005;13:91-5.
  • Zülfikar B. Hemofili. Türkiye Klinikleri Pediatrik Bilimler Dergisi 2005;1:53-68.
  • Yörükoğlu A. Çocuk Ruh Sağlığı. 1. Baskı. İstanbul: Özgür yayınları; 1996.
  • Polanczyk G, De Lima M, Horta B, Biederman J, Rohde L. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 2007;164:942-8.
  • Merrill R M, Lyon JL, Baker RK, Gren LH. Attention deficit hyperactivity disorder and increased risk of injury. Adv Med Sci 2009;54:20-6.
  • Shilon Y, Pollak Y, Aran A, Shaked S, Gross‐Tsur V. Accidental injuries are more common in children with attention deficit hyperactivity disorder compared with their non‐affected siblings. Child Care Health Dev 2012;38:366-70.
  • 12-Van den Ban E, Souverein P, Meijer W, Van Engeland H, Swaab H, Egberts T et al. Association between ADHD drug use and injuries among children and adolescents. Eur Child Adolesc Psychiatry 2014;23:95-102.
  • Marcus SC, Wan G J, Zhang H F, Olfson M. Injury among stimulant-treated youth with ADHD. J Atten Disord 2008;12:64-9.
  • Pastor PN, Reuben CA. Identified attention-deficit/hyperactivity disorder and medically attended, nonfatal injuries: US school-age children, 1997–2002. Ambul Pediatr 2006;6:38-44.
  • Tai YM, Gau SSF, Gau C S. Injury-proneness of youth with attention-deficit hyperactivity disorder: A national clinical data analysis in Taiwan. Res Dev Disabil 2013;34:1100-8.
  • Rowe R, Maughan B, Goodman R. Childhood psychiatric disorder and unintentional injury: findings from a national cohort study. J Pediatr Psychol 2004;29:119-30.
  • Brehaut JC, Miller A, Raina P, McGrail KM. Childhood behavior disorders and injuries among children and youth: a population-based study. Pediatrics 2003;111:262-9.
  • Pless IB, Taylor HG, Arsenault L. The relationship between vigilance deficits and traffic injuries involving children. Pediatrics 1995;95:219-24.
  • Rosen BN, Peterson L. Gender differences in children's outdoor play injuries: A review and an integration. Clin Psychol 1990;10:187-205.
  • Uslu M, Uslu R, Eksioglu F, Ozen NE. Children with fractures show higher levels of impulsive-hyperactive behavior. Clin Orthop Relat Res 2007;460:192-5.
  • Barkley RA. ADHD and accident proneness. The ADHD Report 2002;10:2-6.
  • Chen G, Smith GA, Deng S, Chen D, Kelleher K, Xiang H. Psychological symptoms and nonfatal unintentional injuries among Chinese adolescents: a prospective study. J Adolesc Health 2005;37:460-6.
  • Wodrich DL, Recht M, Gradowski M, Wagner L. Is attention deficit hyperactivity disorder over-represented mong HIV-seronegative boys with haemophilia? Preliminary results from our centre. Haemophilia 2003;9:593–7.
  • Spencer ML, Wodrich DL, Schultz W, Wagner L, Recht M. Inattention, hyperactivity-impulsivity, academic skills and psychopathology in boys with and without haemophilia. Haemophilia 2009;15:701-6.
  • Turgay, A. Disruptive Behavior Disorders: Child and Adolescent Screening and Rating Scales for Children, Adolescents, Parents and Teachers. Michigan: Integrative Therapy Institute Publication; 1994.
  • Ercan ES, Amado S, Somer O, Çıkoğlu S. Dikkat eksikliği hiperaktivite bozukluğu ve yıkıcı davranım bozuklukları için bir test bataryası geliştirme çabası. Çocuk ve Gençlik Ruh Sağlığı Dergisi 2001;8:132-44.
  • Kavaklı K. Hemofililer. Anak SS, Aydoğan G, Çetin M, İrken G, Kemahlı S, Öztürk G, ve ark. Editörler. Pediatrik Hematoloji. 1. Baskı. İstanbul: İstanbul Medikal Yayıncılık; 2011. p.479-94.
  • Shapiro AD, Donfield SM, Lynn HS, Cool VA, Stehbens JA, Hunsberger SL, et al. Defining the impact of hemophilia: the Academic Achievement in Children with Hemophilia Study Pediatrics 2001;108:1-6.
  • DiScala C, Lescohier I, Barthel M, Li G. Injuries to children with attention deficit hyperactivity disorder. Pediatrics 1998;102:1415-21.
  • Lee LC, Harrington RA, Chang JJ, Connors SL. Increased risk of injury in children with developmental disabilities. Res Dev Disabil 2008;29:247-55.
Toplam 30 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Tr
Bölüm Makaleler
Yazarlar

Nusret Soylu

Göksel Leblebisatan Bu kişi benim

Ömer Uçur Bu kişi benim

Fatih Yıldırım Bu kişi benim

Yayımlanma Tarihi 14 Aralık 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 22 Sayı: 3

Kaynak Göster

APA Soylu, N., Leblebisatan, G., Uçur, Ö., Yıldırım, F. (2015). Investigation of the Relation Between Intraarticular Bleedings and Symptom Severity of Attention Deficit Hyperactivity Disorder in Children and Adolescents with Haemophilia. Journal of Turgut Ozal Medical Center, 22(3), 171-175.
AMA Soylu N, Leblebisatan G, Uçur Ö, Yıldırım F. Investigation of the Relation Between Intraarticular Bleedings and Symptom Severity of Attention Deficit Hyperactivity Disorder in Children and Adolescents with Haemophilia. Turgut Özal Tıp Merk Derg. Aralık 2015;22(3):171-175.
Chicago Soylu, Nusret, Göksel Leblebisatan, Ömer Uçur, ve Fatih Yıldırım. “Investigation of the Relation Between Intraarticular Bleedings and Symptom Severity of Attention Deficit Hyperactivity Disorder in Children and Adolescents With Haemophilia”. Journal of Turgut Ozal Medical Center 22, sy. 3 (Aralık 2015): 171-75.
EndNote Soylu N, Leblebisatan G, Uçur Ö, Yıldırım F (01 Aralık 2015) Investigation of the Relation Between Intraarticular Bleedings and Symptom Severity of Attention Deficit Hyperactivity Disorder in Children and Adolescents with Haemophilia. Journal of Turgut Ozal Medical Center 22 3 171–175.
IEEE N. Soylu, G. Leblebisatan, Ö. Uçur, ve F. Yıldırım, “Investigation of the Relation Between Intraarticular Bleedings and Symptom Severity of Attention Deficit Hyperactivity Disorder in Children and Adolescents with Haemophilia”, Turgut Özal Tıp Merk Derg, c. 22, sy. 3, ss. 171–175, 2015.
ISNAD Soylu, Nusret vd. “Investigation of the Relation Between Intraarticular Bleedings and Symptom Severity of Attention Deficit Hyperactivity Disorder in Children and Adolescents With Haemophilia”. Journal of Turgut Ozal Medical Center 22/3 (Aralık 2015), 171-175.
JAMA Soylu N, Leblebisatan G, Uçur Ö, Yıldırım F. Investigation of the Relation Between Intraarticular Bleedings and Symptom Severity of Attention Deficit Hyperactivity Disorder in Children and Adolescents with Haemophilia. Turgut Özal Tıp Merk Derg. 2015;22:171–175.
MLA Soylu, Nusret vd. “Investigation of the Relation Between Intraarticular Bleedings and Symptom Severity of Attention Deficit Hyperactivity Disorder in Children and Adolescents With Haemophilia”. Journal of Turgut Ozal Medical Center, c. 22, sy. 3, 2015, ss. 171-5.
Vancouver Soylu N, Leblebisatan G, Uçur Ö, Yıldırım F. Investigation of the Relation Between Intraarticular Bleedings and Symptom Severity of Attention Deficit Hyperactivity Disorder in Children and Adolescents with Haemophilia. Turgut Özal Tıp Merk Derg. 2015;22(3):171-5.