The effect of hyperlipidemia on hearing function

Yıl 2002, Cilt: 9 Sayı: 2, 112 - 116, 12.03.2002

Turgut Karlıdağ İrfan Kaygusuz Şinasi Yalçın Erhan Demirbağ Yasemin Açık M. Yüksel Güngör

Öz

Objectives: We evaluated the effects of hyperlipi­ demia on hearing function.Patients and Methods: The study included 274 hyperlipidemic patients 176 females, 98 males; age range 35 to 60 years who manifested normal tym- panic membrane findings, no history of noise expo- sure, and chronic systemic or ear diseases. Sixty healthy subjects 36 females, 24 males with normal serum lipid levels were enrolled as Controls. Subjects who had elevated serum total cholesterol, triglyceride, and very low density lipoprotein VLDL levels, and normal lipid levels were divided into four groups and their hearing functions were analysed with pure-tone audiometry.Results: Evaluation of ali groups shovved significantly increased hearing levels at three frequencies in female patients, and at six frequencies in male patients p<0.05 . Significant increases in hearing lev­ els were observed both in females and males at 8000 Hz in three groups, at 6000 Hz in the VLDL group, and in males at 2000 Hz in the total cholesterol and VLDL groups p<0.05 . When both female and male patients were evaluated together, the largest difference was detected in the VLDL group at five frequencies.Conclusion: The findings of our study suggest that hyperlipidemia may have a role on the occurrence of sensorineural hearing loss.

Anahtar Kelimeler

Audiometry, pure-tone, cholesterol/blood, hearing/physiology, hearing loss, sensorineural/etiology, hyperlipidemia/complications, triglycerides/blood

Hiperlipideminin işitme fonksiyonu üzerine etkisi

Öz

Amaç: Hiperlipideminin iflitme fonksiyonu üzerine etkilerini değerlendirdik.Hastalar ve Yöntemler: Çalıflmaya hiperlipidemi tanısı konan 274 hasta alındı. Olguların hepsinde kulak zarı bulguları normaldi; gürültüye maruz kalma hikayesi yoktuve iflitme ile ilgili veya sistemik kronik bir hastalığı bulunmuyordu. Aynı ölçütlere sahip, serum lipid düzeyleri normal 60 kifliden 36 kadın, 24 erkek kontrol grubu oluflturuldu. Serum total kolesterol, trigliserid veçok düflük dansiteli lipoprotein VLDL düzeyleri yüksek olan ve normal lipid değerine sahip olgular dörtgruba ayrılarak iflitme fonksiyonları saf ses odyometriile değerlendirildi.Bulgular: Kontrol grubuna göre kadın hastalarda üç frekansta, erkek hastalarda ise altı frekansta iflitme ortalamalarında anlamlı yükselme görüldü p

Anahtar Kelimeler

Odyometri, saf-ses, kolesterol/kan, iflitme/fizyoloji, iflitme kaybı, sensorinöral/etyoloji, hiperlipidemi/komplikasyon, trigliserid/kan

Kaynakça

• Saito T, Sato K, Saito H. An experimental study of auditory dysfunction associated with hyperlipopro- teinemia. Arch Otorhinolaryngol 1986;243:242-5.
• Gulya AJ. Sensorineural hearing losses of adulthood. In: Cummings CW, Fredrickson JM, Harker LA, Krause CJ, Schuller DE, editors. Otolaryngology head neck surgery. 2nd ed. St. Louis: Mosby Year Book; 1993. p. 3113-20.
• Balkan E, Balkan S, Yaltkaya K, Değer N. Beyin sapı iflitsel uyarılmıfl potansiyellerinin hiperlipidemik ve normolipidemik kiflilerde karflılafltırılması. Türk ORL Arflivi 1990;28:105-8.
• Suzuki K, Kaneko M, Murai K. Influence of serum lipids on auditory function. Laryngoscope 2000;110(10 Pt 1):1736-8.
• Rosen S, Plester D, El-Mofty A, Rosen HV. Relation of hearing loss to cardiovascular disease. Trans Am Acad Ophthalmol Otol 1964;68:433-4. [Abstract]
• M e y e rh o ff WL, Liston SL. Metabolic hearing loss. In: P a p a rella MM, Shumrick DA, Gluckman JL, Meyerh o ff WL, editors. Otolaryngology. 3rd ed. Philadelphia: W. B . Saunders; 1991. p. 1671-81.
• Kojima Y, Ito S, Furuya N. Hearing improvement after therapy for hyperlipidemia in patients with chronic- phase sudden deafness. Ann Otol Rhinol Laryngol 2001;110:105-8.
• Tami TA, Fankhauser CE, Mehlum DL. Effects of noise exposure and hypercholesterolemia on auditory func- tion in the New Zealand white rabbit. Otolaryngol Head Neck Surg 1985;93:235-9.
• Morizono T, Paparella MM. Hypercholesterolemia and auditory dysfunction. Experimental studies. Ann Otol Rhinol Laryngol 1978;87(6 Pt 1):804-14.
• Spencer JT Jr. Hyperlipoproteinemias in the etiology of inner ear disease. Laryngoscope 1973;83:639-78.
• Sikora MA, Morizono T, Ward WD, Paparella MM, Leslie K. Diet-induced hyperlipidemia and auditory dysfunction. Acta Otolaryngol 1986;102:372-81.
• Friedrich G, Pilger E. Lipoproteins in cochleovestibu- lar disorders. Arch Otorhinolaryngol 1981;232:101-5.
• Lee FS, Matthews LJ, Mills JH, Dubno JR, Adkins WY. Analysis of blood chemistry and hearing levels in a sample of older persons. Ear Hear 1998;19:180-90.
• Ünal A, Karatafl A, Yılmaz N, Altuntafl A, Titiz A, Nal- ça Y ve ark. Hiperlipidemik hastalarda odiyolojik de- ğerlendirme. In: Kaytaz A, editör. 24. Ulusal Türk Oto- laringoloji ve Bafl-Boyun Cerrahisi Kongresi Kitabı; 23-27 Eylül 1997; Antalya, Türkiye. 1997. s. 1001-4.
• Witztum JL, Steinberg D. Disorders of lipid metabolism. In: Bennett JC, Plum F, editors. Cecil textbook of medicine. 20th ed. Philadelphia: W.B. Saunders; 1996. p. 1086-94.