A case of natural killer T-cell lymphoma in the nasal cavity

Yıl 2002, Cilt: 9 Sayı: 3, 216 - 219, 28.06.2002

Haluk Özkarakaş Atilla Şengör İlknur Memişoğlu Cengiz Erçin

Öz

CD56 positive natural killer T celi lymphoma is char- acterized by destructive lesions in the nasal cavity and nasopharynx. Severe tissue necrosis makes histopathologic diagnosis difficult, generally necessi- tating multiple biopsies. A thirty-three-year-old male patient presented with complaints of nasal obstruction, hemorrhagic discharge of fetid odor, and rhino- lalia. Immunohistochemical studies on biopsy speci- mens obtained from the lesion in the nasal septum and posterior nasal cavity revealed CD56 positive natural killer T celi lymphoma. The patient was treated with eight courses of combination chemotherapy, since then he has been in remission for more than 1.5 years.

Anahtar Kelimeler

Diagnosis, differential, granuloma, lethal midline/pathology/diagnosis/therapy, killer cells, natural, lymphoma/pathology/diagnosis/therapy, nose neoplasms

Nazal kaviteyi tutan natural killer T hücreli lenfoma: Olgu sunumu

Öz

CD56 pozitif doğal öldürücü natural killer T hücreli lenfoma, nazal kavite ve nazofarenkste tahrip edici orta hat lezyonları ile ortaya çıkan klinik bir durum- dur. Yaygın doku nekrozu nedeniyle histolojik tanısı güçtür. Genellikle multipl biyopsilerle tanıya varıl- maktadır. Otuz üç yaflında erkek hasta, burun tıka- nıklığı, kanlı, kötü kokulu akıntı, burundan konuflma yakınmaları ile baflvurdu. Nazal septum ve kavite posterioruna yerleflmifl lezyondan alınan biyopsiler ve immünhistokimyasal çalıflmalar sonucunda, CD56 pozitif doğal öldürücü T hücreli lenfoma tanısı kondu. Hastaya sekiz kürlük kombinasyon kemoter- apisi uygulandı; aradan geçen 1.5 yıl içinde hastalık halen remisyondadır

Anahtar Kelimeler

Tanı, ayırıcı, granülom, ölümcül ortahat/patoloji/tanı/tedavi, öldürücü hücre, doğal, lenfoma/patoloji/tanı/tedavi, burun neoplazmları

Kaynakça

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