Monitoring the efficacy of immunotherapy by symptom scores and the skin prick test in patients with allergic rhinitis

Yıl 2003, Cilt: 10 Sayı: 6, 221 - 225, 24.12.2003

Yücel Akbaş Mustafa Rahmi Saatçi

Öz

Objectives: We evaluated the role of the skin prick test, symptom scores, and total and specific IgE levels in monitor­ ing the efficacy of immunotherapy in allergic rhinitis.Patients and Methods: Thirty patients with allergic rhinitis were assigned to two treatment groups depending on their pref- erences and their conditions to comply with follow-ups. Thus, 20 patients 12 females, 8 males; mean age 26 years; range 12 to 40 years and 10 Controls 6 females, 4 males; mean age 28 years; range 16 to 48 years received immunotherapy and medical treatment, respectively. Ali the patients were evaluated by skin prick tests, symptom scores, and total and specific IgE lev­ els before, and after 6,12,24, and 36 months of, the treatment.Results: Symptom scores and skin test results differed signifi- cantly after treatment in the immunotherapy group p<0.01 , vvhereas similar results were obtained in the control group.These two parameters also differed significantly betvveen the two groups p<0.05 . No significant differences were found betvveen the total IgE and specific IgE results. Immunotherapy-associated adverse events were few, and none required discontinuation.Conclusion: Skin prick tests and symptom scores can be used in monitoring the efficacy of immunotherapy in patients with allergic rhinitis.

Anahtar Kelimeler

Allergens/immunology/therapeutic use, antigens, Dermatophagoides, desensitization, immunologic, immunotherapy/ methods, monitoring, immunologic/methods, rhinitis, allergic, perennial/therapy/immunology, skin tests

Alerjik rinitte immünterapi etkinliğinin izlenmesinde semptom skoru ve deri testi

Öz

Amaç: Alerjik rinitli hastalarda uyguladığımız immünterapinin etkinliğini izlemede semptom skoru, deri testi, ve total IgE ve spesifik IgE düzeylerinin rolü arafltırıldı.Hastalar ve Yöntemler: Öykü, fizik muayene, deri testi,total IgE ve spesifik IgE değerleri ile alerjik rinit tanısı konan 30 hasta, tercihlerine ve izleme uyum sağlayıp sağlayamayacaklarına göre immünterapi ve medikal tedavi gruplarına ayrıldı. Hastalarda tedavi öncesinde ve tedavinin 6,12, 24 ve 36. aylarında deri testi, semptom skoru, spesifikIgE ve total IgE ölçümleri yapıldı. Bulgular: İmmünterapi grubunda tedavi öncesi ve sonrası semptom skorları ve deri testlerinde anlamlı farklılık bulunurken p

Anahtar Kelimeler

Alerjen/immünoloji/terapötik kullanım, antijen, Dermatophagoides, desensitizasyon, immünolojik, immünterapi/yöntem, izleme, immünolojik/yöntem, rinit, alerjik, perennial/tedavi, immünoloji, deri testi

Kaynakça

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